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Volume 42, Number 12 / December, 2016

Editorial

Sepsis: find me, manage me, and stop me!

Jean-Francois Timsit, Anders Perner
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In Memoriam

In memoriam: Johan Groeneveld

Armand Girbes, Jozef Kesecioglu
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Focus Editorial

Focus on adequate antimicrobial treatment and de-escalation in the ICU

Dominique D. Benoit, Gordon Doig, Jean-Francois Timsit
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Focus on transfusion, bleeding and thrombosis

Elie Azoulay, Yaseen Arabi, Anders Perner
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Focus on acute circulatory failure

Jan Bakker
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Seven-Day Profile Publication

Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study

John G. Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fabiana Madotto, Ednan K. Bajwa, Laurent Brochard, Kevin Clarkson, Andres Esteban, Luciano Gattinoni, Frank van Haren, Leo M. Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Anders Larsson, Daniel F. McAuley, Lia McNamee, Nicolas Nin, Haibo Qiu, Marco Ranieri, Gordon D. Rubenfeld, B. Taylor Thompson, Hermann Wrigge, Arthur S. Slutsky, Antonio Pese
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Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial

Samir Jaber, Marion Monnin, Mehdi Girard, Matthieu Conseil, Moussa Cisse, Julie Carr, Martin Mahul, Jean Marc Delay, Fouad Belafia, Gérald Chanques, Nicolas Molinari, Audrey De Jong
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Original

Effect of early postextubation high-flow nasal cannula vs conventional oxygen therapy on hypoxaemia in patients after major abdominal surgery: a French multicentre randomised controlled trial (OPERA)

Emmanuel Futier, Catherine Paugam-Burtz, Thomas Godet, Linda Khoy-Ear, Sacha Rozencwajg, Jean-Marc Delay, Daniel Verzilli, Jeremie Dupuis, Gerald Chanques, Jean-Etienne Bazin, Jean-Michel Constantin, Bruno Pereira, Samir Jaber
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Review

Diagnosis and management of skin and soft tissue infections in the intensive care unit: a review

Jason P. Burnham, John P. Kirby, Marin H. Kollef
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Systematic Review

Control groups in recent septic shock trials: a systematic review

Ville Pettilä, Peter Buhl Hjortrup, Stephan M. Jakob, Erika Wilkman, Anders Perner, Jukka Takala
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Editorial

In 2035, will all bacteria be multidrug-resistant? No

François Barbier, Jeffrey Lipman, Marc J. M. Bonten
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In 2035, will all bacteria be multidrug resistant? We are not sure

Kevin B. Laupland, Etienne Ruppé, Stephan Harbarth
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The new sepsis consensus definitions: the good, the bad and the ugly

Charles L. Sprung, Roland M. H. Schein, Robert A. Balk
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Systematic Review

Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysisOpen access

Dagmar M. Ouweneel, Jasper V. Schotborgh, Jacqueline Limpens, Krischan D. Sjauw, A. E. Engström, Wim K. Lagrand, Thomas G. V. Cherpanath, Antoine H. G. Driessen, Bas A. J. M. de Mol, José P. S. Henriques
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Original

Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis

Xavier Monnet, Paul Marik, Jean-Louis Teboul
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Pediatric Original

Refractory septic shock in children: a European Society of Paediatric and Neonatal Intensive Care definitionOpen access

Luc Morin, Samiran Ray, Clare Wilson, Solenn Remy, Mohamed Rida Benissa, Nicolaas J. G. Jansen, Etienne Javouhey, Mark J. Peters, Martin Kneyber, Daniele De Luca, Simon Nadel, Luregn Jan Schlapbach, Graeme Maclaren, Pierre Tissieres
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Review

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

Anders Perner, Anthony C. Gordon, Daniel De Backer, George Dimopoulos, James A. Russell, Jeffrey Lipman, Jens-Ulrik Jensen, John Myburgh, Mervyn Singer, Rinaldo Bellomo, Timothy Walsh
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Original

Plasma cytokine levels predict response to corticosteroids in septic shock

Peter Bentzer, Chris Fjell, Keith R. Walley, John Boyd, James A. Russell
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Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study

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The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study

Gareth R. Davies, Suresh Pillai, Matthew Lawrence, Gavin M. Mills, Robert Aubrey, Lindsay D’Silva, Ceri Battle, Rhodri Williams, Rowan Brown, Dafydd Thomas, Keith Morris, Phillip Adrian Evans
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Venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock post-cardiac arrest

Marc Pineton de Chambrun, Nicolas Bréchot, Guillaume Lebreton, Matthieu Schmidt, Guillaume Hekimian, Pierre Demondion, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes, Charles-Edouard Luyt
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Editorial

In sepsis, everything old is new again

Anthony Delaney, Flavia Machado
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What patient data should be collected in this randomized controlled trial in sepsis?

Jean-Louis Vincent, Ignacio Martin-Loeches, Djillali Annane
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In 2035, will all bacteria be multiresistant? Yes

George Dimopoulos, Marin H. Kollef, Jon Cohen
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The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty

Mervyn Singer
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What's New in Intensive Care

What’s new in sepsis recognition in resource-limited settings?Open access

Arthur Kwizera, Emir Festic, Martin W. Dünser
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Alternatives to antibiotics

Bruno François, Hasan S. Jafri, Marc Bonten
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Pediatric sepsis and septic shock management in resource-limited settings

Ndidiamaka Musa, Srinivas Murthy, Niranjan Kissoon
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Recommendations for infection management in patients with sepsis and septic shock in resource-limited settingsOpen access

C. Louise Thwaites, Ganbold Lundeg, Arjen M. Dondorp
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What’s new in skin antisepsis for short-term intravascular catheters: new data to address old problems?

Olivier Mimoz, Vineet Chopra, Andreas Widmer
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What’s new on balanced crystalloid solutions?

Paul Young, Flavia R. Machado, Simon Finfer
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Why biomarkers failed in sepsis

Jens-Ulrik Jensen, Lila Bouadma
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What’s new in surgical treatment of infective endocarditis?

Thierry Carrel, Lars Englberger, Jukka Takala
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Planet’s population on the move, infections on the rise

Garyphallia Poulakou, Diamantis Plachouras
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Should we take into account ESBLs in empirical antibiotic treatment?

Bassetti Matteo, Jesús Rodríguez Baño
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Understanding the Disease

Understanding antibiotic stewardship for the critically ill

J. J. De Waele, J. Schouten, G. Dimopoulos
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Understanding why resistant bacteria are associated with higher mortality in ICU patients

François Barbier, Thiago Lisboa, Saad Nseir
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Understanding clinical signs of poor tissue perfusion during septic shock

Hafid Ait-Oufella, Jan Bakker
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Cardiac dysfunction in sepsis

Anders Aneman, Antoine Vieillard-Baron
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Understanding circulatory failure in sepsis

Andreas Bloch, David Berger, Jukka Takala
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Understanding resistance

François Barbier, Charles-Edouard Luyt
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Understanding host–pathogen interaction

K. Asehnoune, J. Villadangos, R. S. Hotchkiss
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Imaging in Intensive Care Medicine

Common femoral artery pseudoaneurysm

Pablo Blanco, Carolina Godoy, Mariana Torre
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Ultrasonographic diagnosis of tracheal compression

Oliviero Fochi, Moreno Favarato, Ezio Bonanomi
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Kinking, thrombosis and need for re-operation in a patient with a left ventricular assist deviceOpen access

Rahat Muslem, Sakir Akin, Olivier Manintveld, Kadir Caliskan
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Hypermucoviscous Klebsiella pneumoniae pneumonia: follow the string!

Manal Mazloum, Matthieu Le Meur, Guilene Barnaud, Jonathan Messika
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An unusual, iatrogenic cause of massive airleak

Sofoklis Mitsos, Kelvin Lau
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From the Inside

Transforming ICU death into life—radically more

Christos Lazaridis
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Letter

De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition

E. Weiss, J. R. Zahar, M. Garrouste-Orgeas, S. Ruckly, W. Essaied, C. Schwebel, J. F. Timsit
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Extremely high transpulmonary pressure in a spontaneously breathing patient with early severe ARDS on ECMO

Tommaso Mauri, Thomas Langer, Alberto Zanella, Giacomo Grasselli, Antonio Pesenti
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Variability in frequency of consultation and needs assessed by palliative care services across multiple specialty ICUs

Benjamin Stix, Hannah Wunsch, Caitlin Clancy, Craig Blinderman, May Hua
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CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracyOpen access

Mitsuaki Nishikimi, Naoyuki Matsuda, Kota Matsui, Kunihiko Takahashi, Tadashi Ejima, Keibun Liu, Takayuki Ogura, Michiko Higashi, Hitoshi Umino, Go Makishi, Atsushi Numaguchi, Satoru Matsushima, Hideki Tokuyama, Mitsunobu Nakamura, Shigeyuki Matsui
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Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia

Martin Kolditz, André Scherag, Gernot Rohde, Santiago Ewig, Tobias Welte, Mathias Pletz
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Correspondence

Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction

Michihito Kyo, Shinichiro Ohshimo, Nobuaki Shime
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Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction: response to comments by Kyo et al.

Nadir Yehya, Neal J. Thomas, Nuala J. Meyer, Susan S. Margulies
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Infection management in patients with sepsis and septic shock in resource-limited settings: focus on appropriate antimicrobial

Ashraf Roshdy
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Infection management in patients with sepsis and septic shock in resource-limited settings

C. Louise Thwaites, Ganbold Lundeg, Arjen M. Dondorp
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Prone position and VAP incidence in the PROSEVA trial: attention to the causal question when interpreting competing risk analysis

Otavio T. Ranzani, Gianluigi Li Bassi, Antoni Torres
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Prone position and VAP incidence in the PROSEVA trial: attention to the causal question when interpreting competing risk analysis—response to comments by Ranzani et al.

Muriel Rabilloud, Claude Guérin
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You neglected a few

Jason Chertoff
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Challenges with PRONE ventilation in ARDS patients: response to comments by Chertoff

Shailesh Bihari, John G. Laffey, Andrew D. Bersten
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Tardive tachypnea

Jessica Varrone, Kimberly Lavoie, Constantine A. Manthous
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Potential covariates that affect post-extubation breathing effort in children

Yoshiko Kida, Shinichiro Ohshimo, Nobuaki Shime
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