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What’s new on emerging resistant Candida species

Andrea Cortegiani| Giovanni Misseri| Anuradha Chowdhary
What's New in Intensive Care
Volume 45, Issue 4 / April , 2019

Pages 512 - 515

No abstract available.

References

  1. Bassetti M, Garnacho-Montero J, Calandra T et al (2017) Intensive Care medicine research agenda on invasive fungal infection in critically ill patients. Intensive Care Med 43:1225–1238. https://doi.org/10.1007/s00134-017-4731-2
  2. Maubon D, Garnaud C, Calandra T et al (2014) Resistance of Candida spp. to antifungal drugs in the ICU: where are we now? Intensive Care Med 40:1241–1255. https://doi.org/10.1007/s00134-014-3404-7
  3. Alexander BD, Johnson MD, Pfeiffer CD et al (2013) Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin Infect Dis 56:1724–1732. https://doi.org/10.1093/cid/cit136
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  4. Pfaller MA, Castanheira M, Lockhart SR et al (2012) Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata. J Clin Microbiol 50:1199–1203. https://doi.org/10.1128/JCM.06112-11
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  5. Pham CD, Iqbal N, Bolden CB et al (2014) Role of FKS mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance. Antimicrob Agents Chemother 58:4690–4696. https://doi.org/10.1128/AAC.03255-14
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  6. Klotz U, Schmidt D, Willinger B et al (2016) Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria. Mycoses 59:312–318. https://doi.org/10.1111/myc.12472
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  7. Marcos-Zambrano LJ, Escribano P, Sanchez C et al (2014) Antifungal resistance to fluconazole and echinocandins is not emerging in yeast isolates causing fungemia in a Spanish tertiary care center. Antimicrob Agents Chemother 58:4565–4572. https://doi.org/10.1128/AAC.02670-14
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  8. Delliere S, Healey K, Gits-Muselli M et al (2016) Fluconazole and echinocandin resistance of candida glabrata correlates better with antifungal drug exposure rather than with MSH2 mutator genotype in a french cohort of patients harboring low rates of resistance. Front Microbiol 7:2038. https://doi.org/10.3389/fmicb.2016.02038
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  9. Scapaticci M, Bartolini A, Del Chierico F et al (2018) Phenotypic typing and epidemiological survey of antifungal resistance of Candida species detected in clinical samples of Italian patients in a 17 months’ period. Germs 8:58–66. https://doi.org/10.18683/germs.2018.1132
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  10. Castanheira M (2018) Fungemia surveillance in Denmark demonstrates emergence of non-albicans Candida species and higher antifungal usage and resistance rates than in other nations. J Clin Microbiol 56:e01907–e01917. https://doi.org/10.1128/JCM.01907-17
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  11. Singh A, Healey KR, Yadav P et al (2018) Absence of azole or echinocandin resistance in Candida glabrata isolates in India despite background prevalence of strains with defects in the DNA mismatch repair pathway. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00195-18
  12. Perlin DS (2015) Echinocandin resistance in Candida. Clin Infect Dis 61(Suppl 6):S612–S617. https://doi.org/10.1093/cid/civ791
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  13. Arendrup MC, Patterson TF (2017) Multidrug-resistant Candida: epidemiology, molecular mechanisms, and treatment. J Infect Dis 216:S445–S451. https://doi.org/10.1093/infdis/jix131
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  14. Shields RK, Nguyen MH, Clancy CJ (2015) Clinical perspectives on echinocandin resistance among Candida species. Curr Opin Infect Dis 28:514–522
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  15. Schell WA, Jones AM, Borroto-Esoda K, Alexander BD (2017) Antifungal activity of SCY-078 and standard antifungal agents against 178 clinical isolates of resistant and susceptible Candida species. Antimicrob Agents Chemother 62:e00195-18. https://doi.org/10.1128/AAC.01102-17
  16. Kohlenberg A, Struelens MJ, Monnet DL, Plachouras D (2018) Candida auris: epidemiological situation, laboratory capacity and preparedness in European Union and European Economic Area countries, 2013 to 2017. Euro Surveill. https://doi.org/10.2807/1560-7917.ES.2018.23.13.18-00136
  17. Chowdhary A, Sharma C, Meis JF (2017) Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally. PLoS Pathog 13:e1006290. https://doi.org/10.1371/journal.ppat.1006290
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  18. https://www.cdc.gov/fungal/diseases/candidiasis/tracking-c-auris.html. Accessed 6 May 2018
  19. Lockhart SR, Etienne KA, Vallabhaneni S et al (2017) Simultaneous emergence of multidrug-resistant candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis 64:134–140. https://doi.org/10.1093/cid/ciw691
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  20. Ku TSN, Walraven CJ, Lee SA (2018) Candida auris: disinfectants and implications for infection control. Front Microbiol 9:726. https://doi.org/10.3389/fmicb.2018.00726
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  21. Kordalewska M, Lee A, Park S et al (2018) Understanding echinocandin resistance in the emerging pathogen Candida auris. Antimicrob Agents Chemother 62:e00238-18. https://doi.org/10.1128/AAC.00238-18
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  22. Chowdhary A, Prakash A, Sharma C et al (2018) A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–2017) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance. J Antimicrob Chemother 73:891–899. https://doi.org/10.1093/jac/dkx480
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  23. Hager CL, Larkin EL, Long LA, Ghannoum MA (2018) Evaluation of the efficacy of rezafungin, a novel echinocandin, in the treatment of disseminated Candida auris infection using an immunocompromised mouse model. J Antimicrob Chemother 73:2085–2088. https://doi.org/10.1093/jac/dky153
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