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Observational vs randomized: David vs Goliath for thromboprophylaxis in critically ill patients?

Julie Helms| Julian Bion| Audrey De Jong
Editorial
Volume 45, Issue 2 / February , 2019

Pages 272 - 274

No abstract available.

References

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  2. Cook D, Crowther M, Meade M, Rabbat C, Griffith L, Schiff D, Geerts W, Guyatt G (2005) Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors. Crit Care Med 33:1565–1571
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  3. Alhazzani W, Lim W, Jaeschke RZ, Murad MH, Cade J, Cook DJ (2013) Heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care Med 41:2088–2098
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  4. Cook D, Meade M, Guyatt G, Walter S, Heels-Ansdell D, Warkentin TE, Zytaruk N, Crowther M, Geerts W, Cooper DJ, Vallance S, Qushmaq I, Rocha M, Berwanger O, Vlahakis NE (2011) Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med 364:1305–1314
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  5. De Jong A, Clavieras N, Conseil M, Coisel Y, Moury PH, Pouzeratte Y, Cisse M, Belafia F, Jung B, Chanques G, Molinari N, Jaber S (2014) Implementation of a combo videolaryngoscope for intubation in critically ill patients: a before-after comparative study. Intensive Care Med 39:2144–2152
  6. Landelle C, Nocquet Boyer V, Abbas M, Genevois E, Abidi N, Naimo S, Raulais R, Bouchoud L, Boroli F, Terrisse H, Bosson JL, Harbarth S, Pugin J (2018) Impact of a multifaceted prevention program on ventilator-associated pneumonia including selective oropharyngeal decontamination. Intensive Care Med 44:1777–1786
  7. Zhu B, Li Z, Jiang L, Du B, Jiang Q, Wang M, Lou R, Xi X (2015) Effect of a quality improvement program on weaning from mechanical ventilation: a cluster randomized trial. Intensive Care Med 41:1781–1790
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  9. Timsit JF, de Kraker MEA, Sommer H, Weiss E, Bettiol E, Wolkewitz M, Nikolakopoulos S, Wilson D, Harbarth S (2017) Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net. Intensive Care Med 43:1002–1012
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  11. Pagoto SL, Lemon SC (2013) Efficacy vs effectiveness. JAMA Intern Med 173:1262–1263
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  12. Glasgow RE, Lichtenstein E, Marcus AC (2003) Why don’t we see more translation of health promotion research to practice? Rethinking the efficacy-to-effectiveness transition. Am J Public Health 93:1261–1267
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  13. Flay BR (1986) Efficacy and effectiveness trials (and other phases of research) in the development of health promotion programs. Prev Med 15:451–474
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  14. Bailly S, Meyfroidt G, Timsit JF (2018) What’s new in ICU in 2050: big data and machine learning. Intensive Care Med 44:1524–1527
  15. Concato J, Shah N, Horwitz RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342:1887–1892
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