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Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

Peter Pickkers| James A. Russell
Editorial
Volume 45, Issue 2 / February , 2019

Pages 282 - 283

No abstract available.

References

  1. Opal SM et al (1999) Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J Infect Dis 180(5):1584–1589
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  2. Zhou F et al (2013) Blood purification and mortality in sepsis: a meta-analysis of randomized trials. Crit Care Med 41(9):2209–2220
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  3. Cruz DN et al (2009) Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 301(23):2445–2452
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  4. Vincent JL (2009) Polymyxin B hemoperfusion and mortality in abdominal septic shock. JAMA 302(18):1968 (author reply 1969–70)
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  5. Payen DM et al (2015) Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med 41(6):975–984
  6. Dellinger R et al (2018) Effect of targeted polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level: the euphrates randomized clinical trial. JAMA 320(14):1455–1463
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  7. Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M (2018) Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial. ICM. https://doi.org/10.1007/s00134-018-5463-7
  8. Opal SM et al (2013) Effect of eritoran, an antagonist of md2-tlr4, on mortality in patients with severe sepsis: the access randomized trial. JAMA 309(11):1154–1162
    • View reference on publisher's website

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