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Future of the ICU: finding treatable needles in the data haystack

Lieuwe D. J. Bos| Elie Azoulay| Ignacio Martin-Loeches
What's New in Intensive Care
Volume 45, Issue 2 / February , 2019

Pages 240 - 242

No abstract available.

References

  1. Singer M, Deutschman CS, Seymour C et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA J Am Med Assoc 315:801–810. https://doi.org/10.1001/jama.2016.0287
    • View reference on publisher's website
  2. Rhodes A, Evans LE, Alhazzani W (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock. Springer, Berlin. https://doi.org/10.1007/s00134-017-4683-6
  3. Marshall JC (2014) Why have clinical trials in sepsis failed? Trends Mol Med 20:195–203. https://doi.org/10.1016/j.molmed.2014.01.007
    • View reference on publisher's website
  4. Hotchkiss RS, Coopersmith CM, McDunn JE et al (2009) The sepsis seesaw: tilting toward immunosuppression. Nat Med. https://doi.org/10.1038/nm0509-496
  5. Davenport EE, Burnham KL, Radhakrishnan J et al (2016) Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 4:259–271. https://doi.org/10.1016/S2213-2600(16)00046-1
    • View reference on publisher's website
  6. Scicluna BP, van Vught LA, Zwinderman AH et al (2017) Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med. https://doi.org/10.1016/s2213-2600(17)30294-1
  7. Antcliffe DB, Burnham KL, Al-Beidh F et al (2018) Transcriptomic signatures in sepsis and a differential response to steroids: from the VANISH randomized trial. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.201807-1419oc
  8. Pickkers P, Kox M (2017) Towards precision medicine for sepsis patients. Crit Care 21:2016–2018. https://doi.org/10.1186/s13054-016-1583-z
    • View reference on publisher's website
  9. Harrison AM, Gajic O, Pickering BW et al (2016) Development and implementation of sepsis alert systems. Clin Chest Med 37:219–229. https://doi.org/10.1016/j.ccm.2016.01.004
    • View reference on publisher's website
  10. Komorowski M, Celi LA, Badawi O et al (2018) The artificial intelligence clinician learns optimal treatment strategies for sepsis in intensive care. Nat Med. https://doi.org/10.1038/s41591-018-0213-5
  11. Knox DB, Lanspa MJ, Kuttler KG et al (2015) Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med 41:814–822. https://doi.org/10.1007/s00134-015-3764-7

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