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Understanding hepatic encephalopathy

Nicolas Weiss| Rajiv Jalan| Dominique Thabut
Understanding the Disease
Volume 44, Issue 2 / February , 2018

Pages 231 - 234

No abstract available.

References

  1. Mouri S, Tripon S, Rudler M et al (2015) Four score, a reliable score for assessing overt hepatic encephalopathy in cirrhotic patients. Neurocrit Care 22:251–257
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  2. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT (2002) Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35:716–721
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  3. Holecek M (2015) Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy. Nutrition 31:14–20
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  4. Romero-Gómez M, Jover M, Del Campo JA et al (2010) Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis: a cohort study. Ann Intern Med 153:281–288
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  5. Romero-Gómez M, Montagnese S, Jalan R (2015) Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure. J Hepatol 62:437–447
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  6. Weiss N, Rosselli M, Mouri S et al (2016) Modification in CSF specific gravity in acutely decompensated cirrhosis and acute on chronic liver failure independent of encephalopathy, evidences for an early blood-CSF barrier dysfunction in cirrhosis. Metab Brain Dis. doi:10.1007/s11011-016-9916-9
  7. Selvapatt N, Singanayagam A, Wendon J, Antoniades CG (2014) Understanding infection susceptibility in patients with acute-on-chronic liver failure. Intensive Care Med 40:1363–1366
  8. Palomero-Gallagher N, Zilles K (2013) Neurotransmitter receptor alterations in hepatic encephalopathy: a review. Arch Biochem Biophys 536:109–121
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  9. Weiss N, Barbier Saint Hilaire P, Colsch B et al (2016) Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy. J Hepatol 65:1120–1130
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  10. Shawcross DL, Davies NA, Williams R, Jalan R (2004) Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 40:247–254
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  11. Thabut D, Massard J, Gangloff A et al (2007) Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure. Hepatology 46:1872–1882
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  12. Bajaj JS, O’Leary JG, Reddy KR et al (2012) Second infections independently increase mortality in hospitalized patients with cirrhosis: the North American consortium for the study of end-stage liver disease (NACSELD) experience. Hepatology 56:2328–2335
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  13. Wasmuth HE, Kunz D, Yagmur E et al (2005) Patients with acute on chronic liver failure display “sepsis-like” immune paralysis. J Hepatol 42:195–201
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  14. Berry PA, Antoniades CG, Carey I et al (2011) Severity of the compensatory anti-inflammatory response determined by monocyte HLA-DR expression may assist outcome prediction in cirrhosis. Intensive Care Med 37:453–460
  15. Weiss N, Junot C, Rudler M et al (2016) Hepatic vs. drug-induced encephalopathy in cirrhotic patients? Liver Int 36:1233–1234
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