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Iron deficiency and infection: another pathway to explore in critically ill patients?

Erik R. Swenson| Raphaël Porcher| Michaël Piagnerelli
Editorial
Volume 44, Issue 12 / December , 2018

Pages 2260 - 2262

No abstract available.

References

  1. Hayden SJ, Albert TJ, Watkins TR, Swenson ER (2012) Anemia in critical illness: insights into etiology, consequences, and management. Am J Respir Crit Care Med 185:1049–1057
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  2. Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, Flaxman SR, Pullan RL, Brooker SJ, Murray CJ (2014) A systematic analysis of global anemia burden from 1990 to 2010. Blood 123:615–624
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  3. Stauder R, Valer P, Theurl I (2018) Anemia at older age: etiologies, clinical implication, and management. Blood 131:505–514
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  4. Ferrucci L, Guralnik JM, Bandinelli S, Semba RD, Lauretani F, Corsi A, Ruggerio C, Ershler WB, Longo DL (2007) Types of anaemia in older patients is characterised by low levels of erythropoietin and levels of pro-inflammatory markers. Br J Haematol 136:849–855
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  5. Ganz T, Nemeth E (2015) Iron homeostasis in host defence and inflammation. Nat Rev Immunol 15:500–510
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  6. Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L (2011) Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 118:736–746
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  7. Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. NEJM 364:656–665
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  8. Mohus RM, Paulsen J, Gustad L, Askim L, Askim A, Mehl A, DeWan AT, Afset JE, Asvold BO, Solligard E, Damas JK (2018) Association of iron status with the risk of bloodstream infections: results from the prospective population-based HUNT Study in Norway. Intens Care Med 44:1276–1283
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  9. Fonseca C, Marques F, Robalo Nunes A, Belo A et al (2016) Prevalence of anaemia and iron deficiency in Portugal: the EMPIRE study. Intern Med J 46:470–478
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  10. Vincent JL, Piagnerelli M (2006) Transfusion in the intensive care unit. Crit Care Med 34:S96–S101
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  11. Piagnerelli M, Cotton F, Herpain A, Rapotec A, Chatti R, Gulbis B, Vincent JL (2013) Time course of iron metabolism in critically ill patients. Acta Clin Belg 68:22–27
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  12. Boshuizen M, Binnekade JM, Nota B, van de Groen K, Cremer OL, Tuinman PR, Horn J, van Bruggen R, Juffermans NP, Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium (2018) Iron metabolism in critically ill patients developing anemia of inflammation: a case control study. Ann Intens Care 8:56
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  13. Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y (2018) Hepcidin protects against lethal Escherichia coli sepsis in mice inoculated with isolates from septic patients. Infect Immun 86:e00253-18
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  14. Stefanova D, Raychev A, Arezes J, Ruchala P, Gabayan V, Skurnik M, Dillon BJ, Horwitz MA, Ganz T, Bulut Y, Nemeth E (2017) Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood 130:245–257
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  15. Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G (2011) Pharmacologic inhibition of hepcidin expression reverse anemia of chronic inflammation in rats. Blood 118:4977–4984
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  16. IRONMAN Investigators, Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B, McMorrow J, Olynyk JK, Richards T, Towler S, Trengove R, Webb S, Australian and New Zealand Intensive Care Society Clinical Trials Group (2016) Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicenter randomized blind trial: a randomized trial of IV iron in critical illness. Intens Care Med 42:1715–1722
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  17. Pierraci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE (2014) A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness. Crit Care Med 42:2048–2057
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