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Innovation and safety in critical care: should we collaborate with the industry? Pro

Anthony C. Gordon| James A. Russell
Volume 44, Issue 12 / December , 2018

Pages 2276 - 2278

No abstract available.


  1. Lima VD, Lourenco L, Yip B, Hogg RS, Phillips P, Montaner JS (2015) AIDS incidence and AIDS-related mortality in British Columbia, Canada, between 1981 and 2013: a retrospective study. Lancet HIV 2:e92–e97
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  2. Lundh A, Lexchin J, Mintzes B, Schroll JB, Bero L (2017) Industry sponsorship and research outcome. Cochrane Database Syst Rev 2:MR000033
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  4. Rosenbaum L (2015) Understanding bias–the case for careful study. N Engl J Med 372:1959–1963
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  5. Chimonas S, DeVito NJ, Rothman DJ (2017) Bringing transparency to medicine: exploring physicians’ views and experiences of the Sunshine Act. Am J Bioeth 17:4–18
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  6. https://www.nihr.ac.uk/funding-and-support/funding-for-research-studies/funding-programmes/invention-for-innovation/. Accessed 18 July 2018
  7. https://wellcome.ac.uk/what-we-do/directories/health-innovation-challenge-fund-projects-funded. Accessed 18 July 2018
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  9. https://mrc.ukri.org/news/browse/mrc-gsk-and-five-leading-uk-universities-collaborate-to-crack-difficult-disease-areas/. Accessed 18 July 2018
  10. Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider EM, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stuber F, Hill AV, Hinds CJ, EEG Investigators (2015) Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med 3:53–60
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  12. Bell J (2017) Life sciences: industrial strategy
  13. Conway-Morris A, Wilson J, Shankar-Hari M (2018) Immune activation in sepsis. Crit Care Clin 34:29–42
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  14. Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AV, Hinds CJ, Knight JC (2016) Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 4:259–271
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  15. Russell JA, Spronk P, Walley KR (2018) Using multiple ‘omics strategies for novel therapies in sepsis. Intensive Care Med 44:509–511
  16. Komorowski M, Celi LA, Badawi O, Gordon AC, Faisal AA (2018) The intensive care AI clinician learns optimal treatment strategies for sepsis. Nat Med. https://doi.org/10.1038/s41591-018-0213-5
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  17. Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmele T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS (2018) Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial. JCI Insight 3:e98960
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  18. McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA, Canadian Critical Care Trials G, Canadian Critical Care Translational Biology G (2018) Cellular immunotherapy for septic shock. A phase I clinical trial. Am J Respir Crit Care Med 197:337–347
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