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Time trends in the reporting of conflicts of interest, funding and affiliation with industry in intensive care research: a systematic review

Michael Darmon| Julie Helms| Audrey De Jong| Peter Buhl Hjortrup| Emmanuel Weiss| Anders Granholm| Riccardo Pinciroli| Charlotte Poussardin| Marie Warrer Petersen| Stéphanie Sigaut| Bruna Brandao Barreto| Morten Hylander Moller| Elie Azoulay
Systematic Review
Volume 44, Issue 10 / October , 2018

Pages 1669 - 1678

Abstract

Purpose

Conflict of interest (COI) may compromise, or have the appearance of compromising, a researcher’s judgment or integrity in conducting or reporting research. We sought to assess time trends of COI and funding statement reporting in the critical care literature.

Methods

PubMed was searched by using Medical Subject Headings and the appropriate corresponding keywords: “INTENSIVE CARE UNIT” or “ICU” as a major topic. Four years in a 15-year time period (2001–2016) were arbitrarily chosen and one study month was randomly selected for each study period. Studies published during the selected months were included in the analysis.

Results

Three hundred and seventy-four studies were evaluated, including five reviews (1.3%) and ten randomized clinical trials (RCTs) (2.7%). COI statements were available in 65% of the studies and 8% had declared COI. COI statement rate, declared COI and funding statements increased over time, while the number of authors affiliated with industry and the discordance between the lack of COI statement and affiliation with industry decreased. Declared COI were more frequent in 2011–2016 as compared to 2001–2010 (OR 4.06; 95% CI 1.15–25.79) and in the higher quartile of a journal’s impact factor (OR of 16.73; 95% CI 3.28–306.20). Surprisingly, focus of the study, country of the first author and/or endorsement of the study by a trial group were not associated with COI statements.

Conclusion

Our study suggests COI reporting to have been unintuitive to most investigators and unreliable before ICMJE statements, and that strong incentives are needed to implement adequate reporting of COI.

Keywords

References

  1. Ferris LE, Fletcher RH (2010) Conflict of interest in peer-reviewed medical journals: the World Association of Medical Editors (WAME) position on a challenging problem. Neurosurgery 66:629–630. https://doi.org/10.1227/01.neu.0000369904.38343.e4
    • View reference on publisher's website
    • View reference on PubMed
  2. Lemmens T (2004) Confronting the conflict of interest crisis in medical research. Monash Bioeth Rev 23:19–40
    • View reference on publisher's website
    • View reference on PubMed
  3. Friedman PJ (2002) The impact of conflict of interest on trust in science. Sci Eng Ethics 8:413–420
    • View reference on publisher's website
    • View reference on PubMed
  4. Bekelman JE, Li Y, Gross CP (2003) Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 289:454–465
    • View reference on publisher's website
    • View reference on PubMed
  5. Elliott KC (2008) Scientific judgment and the limits of conflict-of-interest policies. Acc Res 15:1–29. https://doi.org/10.1080/08989620701783725
    • View reference on publisher's website
  6. McCrary SV, Anderson CB, Jakovljevic J et al (2000) A national survey of policies on disclosure of conflicts of interest in biomedical research. N Engl J Med 343:1621–1626. https://doi.org/10.1056/NEJM200011303432207
    • View reference on publisher's website
    • View reference on PubMed
  7. Marušić A, Hren D, Mansi B et al (2014) Five-step authorship framework to improve transparency in disclosing contributors to industry-sponsored clinical trial publications. BMC Med 12:197. https://doi.org/10.1186/s12916-014-0197-z
    • View reference on publisher's website
    • View reference on PubMed
  8. Santhakumar S, Adashi EY (2015) The physician payment sunshine act: testing the value of transparency. JAMA 313:23–24. https://doi.org/10.1001/jama.2014.15472
    • View reference on publisher's website
    • View reference on PubMed
  9. World Association of Medical Editors (2009) Conflict of interest in peer-reviewed medical journals: a policy statement of the World Association of Medical Editors (WAME). J Child Neurol 24:1321–1323. https://doi.org/10.1177/0883073809345928
    • View reference on publisher's website
  10. Cohen JJ (2002) Managing financial conflicts of interest in clinical research. Sci Eng Ethics 8:401–406
    • View reference on publisher's website
    • View reference on PubMed
  11. Rothman DJ, McDonald WJ, Berkowitz CD et al (2009) Professional medical associations and their relationships with industry: a proposal for controlling conflict of interest. JAMA 301:1367–1372. https://doi.org/10.1001/jama.2009.407
    • View reference on publisher's website
    • View reference on PubMed
  12. Steinbrook R (2009) Controlling conflict of interest–proposals from the Institute of Medicine. N Engl J Med 360:2160–2163. https://doi.org/10.1056/NEJMp0810200
    • View reference on publisher's website
    • View reference on PubMed
  13. Managing conflict of interest in NIH peer review of grants and contracts. https://grants.nih.gov/grants/peer/peer_coi.htm. Accessed 6 Aug 2018
  14. Krimsky S, Rothenberg LS (1998) Financial interest and its disclosure in scientific publications. JAMA 280:225–226
    • View reference on publisher's website
    • View reference on PubMed
  15. Institute of Medicine (US) Committee on Potential Conflicts of Interest in Patient Outcomes Research Teams (1991) Patient outcomes research teams: managing conflict of interest. National Academies Press, Washington
  16. Drazen JM, de Leeuw PW, Laine C et al (2010) Toward more uniform conflict disclosures—the updated ICMJE conflict of interest reporting form. N Engl J Med 363:188–189. https://doi.org/10.1056/NEJMe1006030
    • View reference on publisher's website
    • View reference on PubMed
  17. Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700
    • View reference on publisher's website
    • View reference on PubMed
  18. Qureshi J, Sud A, Vakil N (2012) Funding source and conflict of interest disclosures by authors and editors in gastroenterology specialty journals revisited. Aliment Pharmacol Ther 35:690–695. https://doi.org/10.1111/j.1365-2036.2011.04989.x
    • View reference on publisher's website
    • View reference on PubMed
  19. Hakoum MB, Jouni N, Abou-Jaoude EA et al (2017) Authors of clinical trials reported individual and financial conflicts of interest more frequently than institutional and nonfinancial ones: a methodological survey. J Clin Epidemiol 87:78–86. https://doi.org/10.1016/j.jclinepi.2017.04.002
    • View reference on publisher's website
    • View reference on PubMed
  20. Bindslev JBB, Schroll J, Gøtzsche PC, Lundh A (2013) Underreporting of conflicts of interest in clinical practice guidelines: cross sectional study. BMC Med Ethics 14:19. https://doi.org/10.1186/1472-6939-14-19
    • View reference on publisher's website
    • View reference on PubMed
  21. Rodwin MA (2018) Attempts to redefine conflicts of interest. Acc Res 25:67–78. https://doi.org/10.1080/08989621.2017.1405728
    • View reference on publisher's website
  22. Bhargava N, Qureshi J, Vakil N (2007) Funding source and conflict of interest disclosures by authors and editors in gastroenterology specialty journals. Am J Gastroenterol 102:1146–1150. https://doi.org/10.1111/j.1572-0241.2007.01268.x
    • View reference on publisher's website
    • View reference on PubMed
  23. Beyari MM, Strain D, Li CS, Lamfon HA (2014) Conflict of interest reporting in dentistry meta-analyses: a systematic review. J Clin Exp Dent 6:e280–e285. https://doi.org/10.4317/jced.51225
    • View reference on publisher's website
    • View reference on PubMed
  24. Lo B, Wolf LE, Berkeley A (2000) Conflict-of-interest policies for investigators in clinical trials. N Engl J Med 343:1616–1620. https://doi.org/10.1056/NEJM200011303432206
    • View reference on publisher's website
    • View reference on PubMed
  25. Neuman J, Korenstein D, Ross JS, Keyhani S (2011) Prevalence of financial conflicts of interest among panel members producing clinical practice guidelines in Canada and United States: cross sectional study. BMJ 343:d5621
    • View reference on publisher's website
    • View reference on PubMed
  26. Choudhry NK, Stelfox HT, Detsky AS (2002) Relationships between authors of clinical practice guidelines and the pharmaceutical industry. JAMA 287:612–617
    • View reference on publisher's website
    • View reference on PubMed
  27. Campsall P, Colizza K, Straus S, Stelfox HT (2016) Financial relationships between organizations that produce clinical practice guidelines and the biomedical industry: a cross-sectional study. PLoS Med 13:e1002029. https://doi.org/10.1371/journal.pmed.1002029
    • View reference on publisher's website
    • View reference on PubMed
  28. Rose SL, Krzyzanowska MK, Joffe S (2010) Relationships between authorship contributions and authors’ industry financial ties among oncology clinical trials. J Clin Oncol 28:1316–1321. https://doi.org/10.1200/JCO.2008.21.6606
    • View reference on publisher's website
    • View reference on PubMed

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