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Intensive care medicine in 2050: ventilator-induced lung injury

Luciano Gattinoni| Tommaso Tonetti| Michael Quintel
What's New in Intensive Care
Volume 44, Issue 1 / January , 2018

Pages 76 - 78

No abstract available.

References

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  3. Tremblay L et al (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Investig 99(5):944–952
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  4. Bellani G et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315(8):788–800
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  6. Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342(18):1301–1308
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  7. Brochard L et al (1998) Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med 158(6):1831–1838
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  8. Stewart TE et al (1998) Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 338(6):355–361
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  9. Brower RG et al (1999) Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 27(8):1492–1498
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  10. Fanelli V et al (2016) Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress sindrome. Crit Care 20:36
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  11. Dreyfuss D, Ricard JD, Gaudry S (2015) Did studies on HFOV fail to improve ARDS survival because they did not decrease VILI? On the potential validity of a physiological concept enounced several decades ago. Intensive Care Med 41(12):2076–2086
  12. Gattinoni L et al (2003) Physical and biological triggers of ventilator-induced lung injury and its prevention. Eur Respir J Suppl 47:15s–25s
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  13. Gattinoni L et al (2016) Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42(10):1567–1575
  14. Cressoni M et al (2014) Lung inhomogeneity in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 189(2):149–158
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  15. Pesenti A et al (2016) Imaging in acute respiratory distress syndrome. Intensive Care Med 42(5):686–698

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