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The research agenda in VAP/HAP: next steps

Michael S. Niederman| Ignacio Martin-Loeches| Antoni Torres
What's New in Intensive Care
Volume 43, Issue 9 / September , 2017

Pages 1389 - 1391

No abstract available.

References

  1. Matar DS, Pham JC, Louis TA, Berenholtz SM (2013) Achieving and sustaining ventilator-associated pneumonia-free time among intensive care units (ICUs): evidence from the Keystone ICU Quality Improvement Collaborative. Infect Control Hosp Epidemiol 34:740–743. doi:10.1086/670989
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  2. Lambert ML, Silversmit G, Savey A, Palomar M, Hiesmayr M, Agodi A et al (2014) Preventable proportion of severe infections acquired in intensive care units: case-mix adjusted estimations from patient-based surveillance data. Infect Control Hosp Epidemiol 35:494–501. doi:10.1086/675824
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  3. Fan Y, Gao F, Wu Y et al (2016) Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis. Crit Care 20:338. doi:10.1186/s13054-016-1506-z
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  4. Martin-Loeches I, Povoa P, Rodríguez A et al (2015) Incidence and prognosis of ventilator-associated tracheobronchitis (TAVeM): a multicentre, prospective, observational study. Lancet Respir Med 3:859–868. doi:10.1016/S2213-2600(15)00326-4
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  5. Douglas IS (2016) New diagnostic methods for pneumonia in the ICU. Curr Opin Infect Dis 29:197–204. doi:10.1097/QCO.0000000000000249
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  6. Torres A, Lee N, Cillóniz C, Vila J, Van der Erden M (2016) Laboratory diagnosis of pneumonia in the molecular age. Eur Respir J 40:1764–1778. doi:10.1183/13993003.01144-2016
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  7. Martin-Loeches I, Deja M, Koulenti D, Dimopoulos G, Marsh B, Torres A, Niederman MS, Rello J, EU-VAP Study Investigators (2013) Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med 39:672–681. doi:10.1007/s00134-012-2808-5
  8. Bos LD, Martin-Loeches I, Kastelijn JB, Gili G, Espasa M, Povoa P et al (2014) The volatile metabolic fingerprint of ventilator-associated pneumonia. Intensive Care Med 40:761–762. doi:10.1007/s00134-014-3260-5
  9. Vincent JL, Bassetti M, François B, Karam G, Chastre J, Torres A et al (2016) Advances in antibiotic therapy in the critically ill. Crit Care 20:133. doi:10.1186/s13054-016-1285-6
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  10. Que YA, Lazar H, Wolff M, François B, Laterre PF, Mercier E et al (2014) Assessment of panobacumab as adjunctive immunotherapy for the treatment of nosocomial Pseudomonas aeruginosa pneumonia. Eur J Clin Microbiol Infect Dis 33:1861–1867. doi:10.1007/s10096-014-2156-1
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  11. Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB et al (2016) Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 63:e61–e111. doi:10.1093/cid/ciw353
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  12. Planquette B, Timsit JF, Misset BY, Schwebel C, Azoulay E, Adrie C et al (2013) Pseudomonas aeruginosa ventilator-associated pneumonia. Predictive factors of treatment failure. Am J Respir Crit Care Med 188:69–76. doi:10.1164/rccm.201210-1897OC
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  13. Niederman MS, Chastre J, Corkery K et al (2012) BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia. Intensive Care Med 38:263–271. doi:10.1007/s00134-011-2420-0
  14. Nseir S, Martin-Loeches I, Makris D et al (2014) Impact of appropriate antimicrobial treatment on transition from ventilator-associated tracheobronchitis to ventilator-associated pneumonia. Crit Care 18:R129. doi:10.1186/cc13940
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  15. De Waele JJ, Lipman J, Akova M, Bassetti M, Dimopoulos G, Kaukonen M et al (2014) Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients. Intensive Care Med 40:1340–1351. doi:10.1007/s00134-014-3403-8

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