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How much excess fluid impairs outcome of sepsis?

Kelly R. Genga| James A. Russell
Editorial
Volume 43, Issue 5 / May , 2017

Pages 680 - 682

No abstract available.

References

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  3. Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA (2011) Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 39(2):259–265
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  5. Genga K, Russell JA (2016) Early liberal fluids for sepsis patients are harmful. Crit Care Med 44(12):2258–2262
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  7. Smith SH, Perner A (2012) Higher vs. lower fluid volume for septic shock: clinical characteristics and outcome in unselected patients in a prospective, multicenter cohort. Crit Care 16(3):R76
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  8. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F et al. (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370(18):1683–1693
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  9. Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD et al. (2015) Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372(14):1301–1311
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  11. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S et al. (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34(6):1589–1596
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  12. Angus DC, Barnato AE, Bell D, Bellomo R, Chong CR, Coats TJ et al. (2015) A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE. ProCESS and ProMISe Investigators, Intensive care medicine. doi:10.1007/s00134-015-3822-1
  13. Russell JA, Moller MH, Annane D (2015) Early goal-directed therapy: from discovery through enthusiasm to equipoise? Intensive Care Med 41:1676–1678
  14. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al. (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801–810
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  15. Levy B, Collin S, Sennoun N, Ducrocq N, Kimmoun A, Asfar P et al. (2010) Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedside. Intensive Care Med 36(12):2019–2029
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  17. Lee WL, Slutsky AS (2010) Sepsis and endothelial permeability. N Engl J Med 363(7):689–691
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