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Focus on infection and sepsis in intensive care patients

Ignacio Martin-Loeches| Anders Perner
Focus Editorial
Volume 42, Issue 4 / April , 2016

Pages 491 - 493

No abstract available.


  1. Martin-Loeches I, Torres A, Rinaudo M et al (2015) Resistance patterns and outcomes in intensive care unit (ICU)-acquired pneumonia. Validation of European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organi. J Infect 70:213–222. doi:10.1016/j.jinf.2014.10.004
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  2. Vallés J, Martin-Loeches I, Torres A et al (2014) Epidemiology, antibiotic therapy and clinical outcomes of healthcare-associated pneumonia in critically ill patients: a Spanish cohort study. Intensive Care Med. doi:10.1007/s00134-014-3239-2
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  3. Nair GB, Niederman MS (2015) Ventilator-associated pneumonia: present understanding and ongoing debates. Intensive Care Med 41:34–48. doi:10.1007/s00134-014-3564-5
  4. Martin-Loeches I, Povoa P, Rodríguez A et al (2015) Incidence and prognosis of ventilator-associated tracheobronchitis (TAVeM): a multicentre, prospective, observational study. Lancet Respir Med 3:859–868. doi:10.1016/S2213-2600(15)00326-4
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  5. Bos LDJ, Martin-Loeches I, Artigas A (2014) Innovations that could improve early recognition of ventilator-associated pneumonia. Intensive Care Med 40:1352–1354
  6. Albrich WC, Harbarth S (2015) Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting. Intensive Care Med 41:1739–1751. doi:10.1007/s00134-015-3978-8
  7. Rodríguez AH, Avilés-Jurado FX, Díaz E et al (2015) Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis. J Infect. doi:10.1016/j.jinf.2015.11.007
  8. Martin-Loeches I, Bos LD, Povoa P et al (2015) Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis. Intensive Care Med Exp 3:26. doi:10.1186/s40635-015-0062-1
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  9. Wolff M, Mourvillier B, Sonneville R, Timsit J-F (2014) My paper 10 years later: infective endocarditis in the intensive care unit. Intensive Care Med 40:1843–1852. doi:10.1007/s00134-014-3490-6
  10. Warhurst G, Maddi S, Dunn G et al (2015) Diagnostic accuracy of SeptiFast multi-pathogen real-time PCR in the setting of suspected healthcare-associated bloodstream infection. Intensive Care Med 41:86–93. doi:10.1007/s00134-014-3551-x
  11. Dark P, Blackwood B, Gates S et al (2015) Accuracy of LightCycler® SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis. Intensive Care Med 41:21–33. doi:10.1007/s00134-014-3553-8
  12. Chakrabarti A, Sood P, Rudramurthy SM et al (2015) Incidence, characteristics and outcome of ICU-acquired candidemia in India. Intensive Care Med 41:285–295. doi:10.1007/s00134-014-3603-2
  13. Colombo AL, Guimarães T, Sukienik T et al (2014) Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter studies sequentially conducted over a 9-year period. Intensive Care Med 40:1489–1498. doi:10.1007/s00134-014-3400-y
  14. Bassetti M, Righi E, Ansaldi F et al (2015) A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med 41:1601–1610. doi:10.1007/s00134-015-3866-2
  15. Martín-Mazuelos E, Loza A, Castro C et al (2015) β-d-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis. Intensive Care Med 41:1424–1432. doi:10.1007/s00134-015-3922-y
  16. Bailly S, Leroy O, Montravers P et al (2015) Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data. Intensive Care Med 41:1931–1940. doi:10.1007/s00134-015-4053-1
  17. León C, Ostrosky-Zeichner L, Schuster M (2014) What’s new in the clinical and diagnostic management of invasive candidiasis in critically ill patients. Intensive Care Med 40:808–819. doi:10.1007/s00134-014-3281-0
  18. Ferreira D, Grenouillet F, Blasco G et al (2015) Outcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization. Intensive Care Med 41:1077–1088. doi:10.1007/s00134-015-3791-4
  19. Terraneo S, Ferrer M, Martín-Loeches I et al (2015) Impact of Candida spp. isolation in the respiratory tract in patients with intensive care unit-acquired pneumonia. Clin Microbiol Infect. doi:10.1016/j.cmi.2015.09.002
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  20. Albert M, Williamson D, Muscedere J et al (2014) Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med 40:1313–1322. doi:10.1007/s00134-014-3352-2

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