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Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics

Jean-Francois Timsit| Giuseppe Citerio| Jan Bakker| Matteo Bassetti| Dominique Benoit| Maurizio Cecconi| J. Randall Curtis| Glenn Hernandez| Margaret Herridge| Samir Jaber| Michael Joannidis| Laurent Papazian| Mark Peters| Pierre Singer| Martin Smith| Marcio Soares| Antoni Torres| Antoine Vieillard-Baron| Elie Azoulay
Year in Review 2013
Volume 40, Issue 4 / April , 2014

Pages 471 - 483

No abstract available.


  1. Hernandez G, Bruhn A, Luengo C et al (2013) Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study. Intensive Care Med 39:1435–1443. doi:10.1007/s00134-013-2982-0
  2. Vassiliou AG, Maniatis NA, Kotanidou A et al (2013) Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients. Intensive Care Med 39:1752–1759. doi:10.1007/s00134-013-3018-5
  3. Delabranche X, Boisrame-Helms J, Asfar P et al (2013) Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy. Intensive Care Med 39:1695–1703. doi:10.1007/s00134-013-2993-x
  4. Levi M, van der Poll T (2013) Endothelial injury in sepsis. Intensive Care Med 39:1839–1842. doi:10.1007/s00134-013-3054-1
  5. Yamakawa K, Ogura H, Fujimi S et al (2013) Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. Intensive Care Med 39:644–652. doi:10.1007/s00134-013-2822-2
  6. Pranskunas A, Koopmans M, Koetsier PM et al (2013) Microcirculatory blood flow as a tool to select ICU patients eligible for fluid therapy. Intensive Care Med 39:612–619. doi:10.1007/s00134-012-2793-8
  7. Dünser MW, Takala J, Brunauer A, Bakker J (2013) Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach. Crit Care 17:326. doi:10.1186/cc12727
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  8. Kurniati NF, Jongman RM, vom Hagen F et al (2013) The flow dependency of Tie2 expression in endotoxemia. Intensive Care Med 39:1262–1271. doi:10.1007/s00134-013-2899-7
  9. Huang DT, Angus DC, Barnato A et al (2013) Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med 39:1760–1775. doi:10.1007/s00134-013-3024-7
  10. Guignant C, Venet F, Planel S et al (2013) Increased MerTK expression in circulating innate immune cells of patients with septic shock. Intensive Care Med 39:1556–1564. doi:10.1007/s00134-013-3006-9
  11. Kim YA, Ha E-J, Jhang WK, Park SJ (2013) Early blood lactate area as a prognostic marker in pediatric septic shock. Intensive Care Med 39:1818–1823. doi:10.1007/s00134-013-2959-z
  12. Suberviola B, Castellanos-Ortega A, Ruiz Ruiz A et al (2013) Hospital mortality prognostication in sepsis using the new biomarkers suPAR and proADM in a single determination on ICU admission. Intensive Care Med 39:1945–1952. doi:10.1007/s00134-013-3056-z
  13. Brinkman S, Abu-Hanna A, de Jonge E, de Keizer NF (2013) Prediction of long-term mortality in ICU patients: model validation and assessing the effect of using in-hospital versus long-term mortality on benchmarking. Intensive Care Med 39:1925–1931. doi:10.1007/s00134-013-3042-5
  14. Shimamoto Y, Fukuda T, Tanaka K et al (2013) Systemic inflammatory response syndrome criteria and vancomycin dose requirement in patients with sepsis. Intensive Care Med 39:1247–1252. doi:10.1007/s00134-013-2909-9
  15. Udy AA, Roberts JA, Lipman J (2013) Clinical implications of antibiotic pharmacokinetic principles in the critically ill. Intensive Care Med 39:2070–2082. doi:10.1007/s00134-013-3088-4
  16. Harron K, Wade A, Muller-Pebody B et al (2013) Risk-adjusted monitoring of blood-stream infection in paediatric intensive care: a data linkage study. Intensive Care Med 39:1080–1087. doi:10.1007/s00134-013-2841-z
  17. Mermel LA, Allon M, Bouza E et al (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 49:1–45. doi:10.1086/599376
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  18. Gowardman JR, Jeffries P, Lassig-Smith M et al (2013) A comparative assessment of two conservative methods for the diagnosis of catheter-related infection in critically ill patients. Intensive Care Med 39:109–116. doi:10.1007/s00134-012-2689-7
  19. Airapetian N, Maizel J, Langelle F et al (2013) Ultrasound-guided central venous cannulation is superior to quick-look ultrasound and landmark methods among inexperienced operators: a prospective randomized study. Intensive Care Med 39:1938–1944. doi:10.1007/s00134-013-3072-z
  20. Bedel J, Vallee F, Mari A et al (2013) Guidewire localization by transthoracic echocardiography during central venous catheter insertion: a periprocedural method to evaluate catheter placement. Intensive Care Med 39:1932–1937. doi:10.1007/s00134-013-3097-3
  21. European Antimicrobial Resistance Surveillance Network (EARS-Net) (2013) Antimicrobial resistance surveillance in Europe 2012. Surveillance report. http://www.ecdc.europa.eu/en/activities/surveillance/EARS-Net. Accessed 29 Jan 2014
  22. Tabah A, Koulenti D, Laupland K et al (2012) Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study. Intensive Care Med 38:1930–1945. doi:10.1007/s00134-012-2695-9
  23. Routsi C, Pratikaki M, Platsouka E et al (2013) Risk factors for carbapenem-resistant gram-negative bacteremia in intensive care unit patients. Intensive Care Med 39:1253–1261. doi:10.1007/s00134-013-2914-z
  24. Oostdijk EAN, Smits L, de Smet AMGA et al (2013) Colistin resistance in gram-negative bacteria during prophylactic topical colistin use in intensive care units. Intensive Care Med 39:653–660. doi:10.1007/s00134-012-2761-3
  25. Halaby T, Al Naiemi N, Kluytmans J et al (2013) Emergence of colistin resistance in Enterobacteriaceae after the introduction of selective digestive tract decontamination in an intensive care unit. Antimicrob Agents Chemother 57:3224–3229. doi:10.1128/AAC.02634-12
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  26. Schultsz C, Bootsma MCJ, Loan HT et al (2013) Effects of infection control measures on acquisition of five antimicrobial drug-resistant microorganisms in a tetanus intensive care unit in Vietnam. Intensive Care Med 39:661–671. doi:10.1007/s00134-012-2771-1
  27. Derde LPG, Cooper BS, Goossens H et al (2014) Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial. Lancet Infect Dis 14:31–39. doi:10.1016/S1473-3099(13)70295-0
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  28. Zahar JR, Garrouste-Orgeas M, Vesin A et al (2013) Impact of contact isolation for multidrug-resistant organisms on the occurrence of medical errors and adverse events. Intensive Care Med 39:2153–2160. doi:10.1007/s00134-013-3071-0
  29. Vogiatzi L, Ilia S, Sideri G et al (2013) Invasive candidiasis in pediatric intensive care in Greece: a nationwide study. Intensive Care Med 39:2188–2195. doi:10.1007/s00134-013-3057-y
  30. Bassetti M, Marchetti M, Chakrabarti A et al (2013) A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med 39:2092–2106. doi:10.1007/s00134-013-3109-3
  31. Di Pasquale M, Esperatti M, Crisafulli E et al (2013) Impact of chronic liver disease in intensive care unit acquired pneumonia: a prospective study. Intensive Care Med 39:1776–1784. doi:10.1007/s00134-013-3025-6
  32. Martin-Loeches I, Deja M, Koulenti D et al (2013) Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med 39:672–681. doi:10.1007/s00134-012-2808-5
  33. Tumbarello M, De Pascale G, Trecarichi EM et al (2013) Clinical outcomes of Pseudomonas aeruginosa pneumonia in intensive care unit patients. Intensive Care Med 39:682–692. doi:10.1007/s00134-013-2828-9
  34. Rello J, Borgatta B, Lisboa T (2013) Risk factors for Pseudomonas aeruginosa pneumonia in the early twenty-first century. Intensive Care Med 39:2204–2206. doi:10.1007/s00134-013-3046-1
  35. Brusselaers N, Labeau S, Vogelaers D, Blot S (2013) Value of lower respiratory tract surveillance cultures to predict bacterial pathogens in ventilator-associated pneumonia: systematic review and diagnostic test accuracy meta-analysis. Intensive Care Med 39:365–375. doi:10.1007/s00134-012-2759-x
  36. Bouza E, Perez Granda MJ, Hortal J et al (2013) Pre-emptive broad-spectrum treatment for ventilator-associated pneumonia in high-risk patients. Intensive Care Med 39:1547–1555. doi:10.1007/s00134-013-2997-6
  37. Villar J, Kacmarek RM (2013) What is new in refractory hypoxemia? Intensive Care Med 39:1207–1210. doi:10.1007/s00134-013-2905-0
  38. Ehrmann S, Roche-Campo F, Papa GFS et al (2013) Aerosol therapy during mechanical ventilation: an international survey. Intensive Care Med 39:1048–1056. doi:10.1007/s00134-013-2872-5
  39. Seymour CW, Yende S, Scott MJ et al (2013) Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study. Intensive Care Med 39:1423–1434. doi:10.1007/s00134-013-2935-7
  40. Martin-Loeches I, Bermejo-Martin JF, Valles J et al (2013) Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia. Intensive Care Med 39:693–702. doi:10.1007/s00134-013-2829-8
  41. Cracco C, Fartoukh M, Prodanovic H et al (2013) Safety of performing fiberoptic bronchoscopy in critically ill hypoxemic patients with acute respiratory failure. Intensive Care Med 39:45–52. doi:10.1007/s00134-012-2687-9
  42. Jong A, Clavieras N, Conseil M et al (2013) Implementation of a combo videolaryngoscope for intubation in critically ill patients: a before–after comparative study. Intensive Care Med 39:2144–2152. doi:10.1007/s00134-013-3099-1
  43. De Gast-Bakker DH, de Wilde RBP, Hazekamp MG et al (2013) Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial. Intensive Care Med 39:2011–2019. doi:10.1007/s00134-013-3085-7
  44. Du Pont-Thibodeau G, Lacroix J (2013) Do cardiac children need more red blood cell transfusions than other critically ill children? Intensive Care Med 39:2050–2052. doi:10.1007/s00134-013-3082-x
  45. Tritschler T, Frey B (2013) Is the number of drugs independently associated with mortality? Intensive Care Med 39:2060–2062. doi:10.1007/s00134-013-3065-y
  46. Vet NJ, Ista E, de Wildt SN et al (2013) Optimal sedation in pediatric intensive care patients: a systematic review. Intensive Care Med 39:1524–1534. doi:10.1007/s00134-013-2971-3
  47. Van de Voorde P, Van Lander A, Colpaert K et al (2013) An urgent plea: give the use of prolonged propofol infusion a second thought. Intensive Care Med 39:2058–2059. doi:10.1007/s00134-013-3058-x
  48. Garcia Guerra G, Joffe AR, Senthilselvan A et al (2013) Incidence of milrinone blood levels outside the therapeutic range and their relevance in children after cardiac surgery for congenital heart disease. Intensive Care Med 39:951–957. doi:10.1007/s00134-013-2858-3
  49. Smulders CA, van Gestel JPJ, Bos AP (2013) Are central line bundles and ventilator bundles effective in critically ill neonates and children? Intensive Care Med 39:1352–1358. doi:10.1007/s00134-013-2927-7
  50. Ramnarayan P, Patel K, Pappachan J et al (2013) Characteristics and outcome of children admitted to adult intensive care units in England, Wales and Northern Ireland (1996–2011). Intensive Care Med 39:2020–2027. doi:10.1007/s00134-013-3010-0
  51. Polito A, Barrett CS, Wypij D et al (2013) Neurologic complications in neonates supported with extracorporeal membrane oxygenation. An analysis of ELSO registry data. Intensive Care Med 39:1594–1601. doi:10.1007/s00134-013-2985-x
  52. Madderom MJ, Reuser JJCM, Utens EMWJ et al (2013) Neurodevelopmental, educational and behavioral outcome at 8 years after neonatal ECMO: a nationwide multicenter study. Intensive Care Med 39:1584–1593. doi:10.1007/s00134-013-2973-1
  53. Brown KL, MacLaren G, Marino BS (2013) Looking beyond survival rates: neurological outcomes after extracorporeal life support. Intensive Care Med 39:1870–1872. doi:10.1007/s00134-013-3050-5
  54. Visser IHE, Hazelzet JA, Albers MJIJ et al (2013) Mortality prediction models for pediatric intensive care: comparison of overall and subgroup specific performance. Intensive Care Med 39:942–950. doi:10.1007/s00134-013-2857-4
  55. Polito A, Piga S, Cogo PE et al (2013) Increased morbidity and mortality in very preterm/VLBW infants with congenital heart disease. Intensive Care Med 39:1104–1112. doi:10.1007/s00134-013-2887-y
  56. Lopez-Herce J, del Castillo J, Matamoros M et al (2013) Factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study. Intensive Care Med 39:309–318. doi:10.1007/s00134-012-2709-7
  57. Oualha M, Gatterre P, Boddaert N et al (2013) Early diffusion-weighted magnetic resonance imaging in children after cardiac arrest may provide valuable prognostic information on clinical outcome. Intensive Care Med 39:1306–1312. doi:10.1007/s00134-013-2930-z
  58. Floh AA, La Rotta G, Wermelt JZ et al (2013) Validation of a new method based on ultrasound velocity dilution to measure cardiac output in paediatric patients. Intensive Care Med 39:926–933. doi:10.1007/s00134-013-2848-5
  59. De Luca D, Piastra M, Chidini G et al (2013) The use of the Berlin definition for acute respiratory distress syndrome during infancy and early childhood: multicenter evaluation and expert consensus. Intensive Care Med 39:2083–2091. doi:10.1007/s00134-013-3110-x
  60. Van Berkel S, Binkhorst M, van Heijst AFJ et al (2013) Adapted ECMO criteria for newborns with persistent pulmonary hypertension after inhaled nitric oxide and/or high-frequency oscillatory ventilation. Intensive Care Med 39:1113–1120. doi:10.1007/s00134-013-2907-y
  61. Dellaca RL, Veneroni C, Vendettuoli V et al (2013) Relationship between respiratory impedance and positive end-expiratory pressure in mechanically ventilated neonates. Intensive Care Med 39:511–519. doi:10.1007/s00134-012-2795-6
  62. Milesi C, Baleine J, Matecki S et al (2013) Is treatment with a high flow nasal cannula effective in acute viral bronchiolitis? A physiologic study. Intensive Care Med 39:1088–1094. doi:10.1007/s00134-013-2879-y
  63. Essouri S, Laurent M, Chevret L et al (2014) Improved clinical and economic outcomes in severe bronchiolitis with pre-emptive nCPAP ventilatory strategy. Intensive Care Med 40:84–91. doi:10.1007/s00134-013-3129-z
  64. Lee JH, Rehder KJ, Williford L et al (2013) Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature. Intensive Care Med 39:247–257. doi:10.1007/s00134-012-2743-5
  65. Mayordomo-Colunga J, Pons M, Lopez Y et al (2013) Predicting non-invasive ventilation failure in children from the SpO(2)/FiO(2) (SF) ratio. Intensive Care Med 39:1095–1103. doi:10.1007/s00134-013-2880-5
  66. Caldarelli V, Borel JC, Khirani S et al (2013) Polygraphic respiratory events during sleep with noninvasive ventilation in children: description, prevalence, and clinical consequences. Intensive Care Med 39:739–746. doi:10.1007/s00134-012-2806-7
  67. Jouvet PA, Payen V, Gauvin F et al (2013) Weaning children from mechanical ventilation with a computer-driven protocol: a pilot trial. Intensive Care Med 39:919–925. doi:10.1007/s00134-013-2837-8
  68. Egelund TA, Wassil SK, Edwards EM et al (2013) High-dose magnesium sulfate infusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study. Intensive Care Med 39:117–122. doi:10.1007/s00134-012-2734-6
  69. Deep A, Goonasekera CDA, Wang Y, Brierley J (2013) Evolution of haemodynamics and outcome of fluid-refractory septic shock in children. Intensive Care Med 39:1602–1609. doi:10.1007/s00134-013-3003-z
  70. Paize F, Makwana N, Baines PB et al (2013) Diastolic dysfunction and N-terminal pro-brain natriuretic peptide in children with meningococcal sepsis. Intensive Care Med 39:1501–1502. doi:10.1007/s00134-013-2948-2
  71. Xu X-J, Tang Y-M, Liao C et al (2013) Inflammatory cytokine measurement quickly discriminates gram-negative from gram-positive bacteremia in pediatric hematology/oncology patients with septic shock. Intensive Care Med 39:319–326. doi:10.1007/s00134-012-2752-4
  72. Schlapbach LJ, Graf R, Woerner A et al (2013) Pancreatic stone protein as a novel marker for neonatal sepsis. Intensive Care Med 39:754–763. doi:10.1007/s00134-012-2798-3
  73. Spaeder MC (2013) Severe adenoviral respiratory infection in children. Intensive Care Med 39:1157–1158. doi:10.1007/s00134-013-2893-0

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