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Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients

Elie Azoulay| Giuseppe Citerio| Jan Bakker| Matteo Bassetti| Dominique Benoit| Maurizio Cecconi| J. Randall Curtis| Glenn Hernandez| Margaret Herridge| Samir Jaber| Michael Joannidis| Laurent Papazian| Mark Peters| Pierre Singer| Martin Smith| Marcio Soares| Antoni Torres| Antoine Vieillard-Baron| Jean-François Timsit
Year in Review 2013
Volume 40, Issue 3 / March , 2014

Pages 305 - 319

No abstract available.


  1. Shehabi Y, Chan L, Kadiman S et al (2013) Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med 39:910–918. doi:10.1007/s00134-013-2830-2
  2. Le Guen M, Liu N, Bourgeois E et al (2013) Automated sedation outperforms manual administration of propofol and remifentanil in critically ill patients with deep sedation: a randomized phase II trial. Intensive Care Med 39:454–462. doi:10.1007/s00134-012-2762-2
  3. Chalumeau-Lemoine L, Stoclin A, Billard V et al (2013) Flexible fiberoptic bronchoscopy and remifentanil target-controlled infusion in ICU: a preliminary study. Intensive Care Med 39:53–58. doi:10.1007/s00134-012-2697-7
  4. Zaal IJ, Spruyt CF, Peelen LM et al (2013) Intensive care unit environment may affect the course of delirium. Intensive Care Med 39:481–488. doi:10.1007/s00134-012-2726-6
  5. Wolters AE, Slooter AJC, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39:376–386. doi:10.1007/s00134-012-2784-9
  6. Perren A, Brochard L (2013) Managing the apparent and hidden difficulties of weaning from mechanical ventilation. Intensive Care Med 39:1885–1895. doi:10.1007/s00134-013-3014-9
  7. Sulemanji DS, Marchese A, Wysocki M, Kacmarek RM (2013) Adaptive support ventilation with and without end-tidal CO2 closed loop control versus conventional ventilation. Intensive Care Med 39:703–710. doi:10.1007/s00134-012-2742-6
  8. Lellouche F, Bouchard P-A, Simard S et al (2013) Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients. Intensive Care Med 39:463–471. doi:10.1007/s00134-012-2799-2
  9. Alexopoulou C, Kondili E, Plataki M, Georgopoulos D (2013) Patient-ventilator synchrony and sleep quality with proportional assist and pressure support ventilation. Intensive Care Med 39:1040–1047. doi:10.1007/s00134-013-2850-y
  10. Blankman P, Hasan D, van Mourik MS, Gommers D (2013) Ventilation distribution measured with EIT at varying levels of pressure support and neurally adjusted ventilatory assist in patients with ALI. Intensive Care Med 39:1057–1062. doi:10.1007/s00134-013-2898-8
  11. Chiumello D, Coppola S, Froio S et al (2013) Noninvasive ventilation in chest trauma: systematic review and meta-analysis. Intensive Care Med 39:1171–1180. doi:10.1007/s00134-013-2901-4
  12. Mojoli F, Iotti GA, Curro I et al (2013) An optimized set-up for helmet noninvasive ventilation improves pressure support delivery and patient-ventilator interaction. Intensive Care Med 39:38–44. doi:10.1007/s00134-012-2686-x
  13. Richard JCM, Lyazidi A, Akoumianaki E et al (2013) Potentially harmful effects of inspiratory synchronization during pressure preset ventilation. Intensive Care Med 39:2003–2010. doi:10.1007/s00134-013-3032-7
  14. Caldarelli V, Borel JC, Khirani S et al (2013) Polygraphic respiratory events during sleep with noninvasive ventilation in children: description, prevalence, and clinical consequences. Intensive Care Med 39:739–746. doi:10.1007/s00134-012-2806-7
  15. Carlucci A, Schreiber A, Mattei A et al (2013) The configuration of bi-level ventilator circuits may affect compensation for non-intentional leaks during volume-targeted ventilation. Intensive Care Med 39:59–65. doi:10.1007/s00134-012-2696-8
  16. Lellouche F, Lipes J (2013) Prophylactic protective ventilation: lower tidal volumes for all critically ill patients? Intensive Care Med 39:6–15. doi:10.1007/s00134-012-2728-4
  17. Waisman D, Faingersh A, Levy C et al (2013) Transient decrease in PaCO2 and asymmetric chest wall dynamics in early progressing pneumothorax. Intensive Care Med 39:137–145. doi:10.1007/s00134-012-2749-z
  18. Matamis D, Soilemezi E, Tsagourias M et al (2013) Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications. Intensive Care Med 39:801–810. doi:10.1007/s00134-013-2823-1
  19. Schmidt M, Kindler F, Gottfried SB et al (2013) Dyspnea and surface inspiratory electromyograms in mechanically ventilated patients. Intensive Care Med 39:1368–1376. doi:10.1007/s00134-013-2910-3
  20. Scales DC (2013) What’s new with tracheostomy? Intensive Care Med 39:1005–1008. doi:10.1007/s00134-013-2904-1
  21. Blot F, Similowski T, Trouillet J-L et al (2008) Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med 34:1779–1787. doi:10.1007/s00134-008-1195-4
  22. Terragni PP, Antonelli M, Fumagalli R et al (2010) Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial. JAMA 303:1483. doi:10.1001/jama.2010.447
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  24. Young D, Harrison DA, Cuthbertson BH et al (2013) Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA 309:2121. doi:10.1001/jama.2013.5154
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  25. Braune S, Kienast S, Hadem J et al (2013) Safety of percutaneous dilatational tracheostomy in patients on extracorporeal lung support. Intensive Care Med 39:1792–1799. doi:10.1007/s00134-013-3023-8
  26. Hernandez G, Pedrosa A, Ortiz R et al (2013) The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial. Intensive Care Med 39:1063–1070. doi:10.1007/s00134-013-2870-7
  27. Jong A, Clavieras N, Conseil M et al (2013) Implementation of a combo videolaryngoscope for intubation in critically ill patients: a before–after comparative study. Intensive Care Med 39:2144–2152. doi:10.1007/s00134-013-3099-1
  28. Touat L, Fournier C, Ramon P et al (2013) Intubation-related tracheal ischemic lesions: incidence, risk factors, and outcome. Intensive Care Med 39:575–582. doi:10.1007/s00134-012-2750-6
  29. Nseir S, Zerimech F, Fournier C et al (2011) Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically Ill patients. Am J Respir Crit Care Med 184:1041–1047. doi:10.1164/rccm.201104-0630OC
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  30. Ferguson ND, Fan E, Camporota L et al (2012) The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 38:1573–1582. doi:10.1007/s00134-012-2682-1
  31. Hernu R, Wallet F, Thiollière F et al (2013) An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital. Intensive Care Med 39:2161–2170. doi:10.1007/s00134-013-3122-6
  32. Villar J, Perez-Mendez L, Blanco J et al (2013) A universal definition of ARDS: the PaO2/FiO(2) ratio under a standard ventilatory setting-a prospective, multicenter validation study. Intensive Care Med 39:583–592. doi:10.1007/s00134-012-2803-x
  33. Chiumello D, Coppola S, Froio S et al (2013) Time to reach a new steady state after changes of positive end expiratory pressure. Intensive Care Med 39:1377–1385. doi:10.1007/s00134-013-2969-x
  34. Adamzik M, Broll J, Steinmann J et al (2013) An increased alveolar CD4+CD25+Foxp3+T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality. Intensive Care Med 39:1743–1751. doi:10.1007/s00134-013-3036-3
  35. Jalkanen V, Yang R, Linko R et al (2013) SuPAR and PAI-1 in critically ill, mechanically ventilated patients. Intensive Care Med 39:489–496. doi:10.1007/s00134-012-2730-x
  36. Fernandez R, Gili G, Villagra A et al (2013) Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients. Intensive Care Med 39:711–716. doi:10.1007/s00134-012-2801-z
  37. Chiumello D, Marino A, Brioni M et al (2013) Visual anatomical lung CT scan assessment of lung recruitability. Intensive Care Med 39:66–73. doi:10.1007/s00134-012-2707-9
  38. Gutierrez G, Das A, Ballarino G et al (2013) Decreased respiratory rate variability during mechanical ventilation is associated with increased mortality. Intensive Care Med 39:1359–1367. doi:10.1007/s00134-013-2937-5
  39. Deye N, Lellouche F, Maggiore SM et al (2013) The semi-seated position slightly reduces the effort to breathe during difficult weaning. Intensive Care Med 39:85–92. doi:10.1007/s00134-012-2727-5
  40. Gattinoni L, Pesenti A, Carlesso E (2013) Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure: impact and clinical fallout through the following 20 years. Intensive Care Med 39:1909–1915. doi:10.1007/s00134-013-3066-x
  41. Bein T, Weber-Carstens S, Goldmann A et al (2013) Lower tidal volume strategy (approximate to 3 ml/kg) combined with extracorporeal CO2 removal versus “conventional” protective ventilation (6 ml/kg) in severe ARDS. Intensive Care Med 39:847–856. doi:10.1007/s00134-012-2787-6
  42. Mauri T, Bellani G, Grasselli G et al (2013) Patient-ventilator interaction in ARDS patients with extremely low compliance undergoing ECMO: a novel approach based on diaphragm electrical activity. Intensive Care Med 39:282–291. doi:10.1007/s00134-012-2755-1
  43. Schmidt M, Tachon G, Devilliers C et al (2013) Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med 39:838–846. doi:10.1007/s00134-012-2785-8
  44. Schmidt M, Zogheib E, Roze H et al (2013) The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med 39:1704–1713. doi:10.1007/s00134-013-3037-2
  45. Roch A, Hraiech S, Masson E et al (2013) Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center. Intensive Care Med 40:74–83. doi:10.1007/s00134-013-3135-1
  46. Pappalardo F, Pieri M, Greco T et al (2013) Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med 39:275–281. doi:10.1007/s00134-012-2747-1
  47. Distelmaier K, Niessner A, Haider D et al (2013) Long-term mortality in patients with chronic obstructive pulmonary disease following extracorporeal membrane oxygenation for cardiac assist after cardiovascular surgery. Intensive Care Med 39:1444–1451. doi:10.1007/s00134-013-2931-y
  48. Al-Soufi S, Buscher H, Nguyen ND et al (2013) Lack of association between body weight and mortality in patients on veno-venous extracorporeal membrane oxygenation. Intensive Care Med 39:1995–2002. doi:10.1007/s00134-013-3028-3
  49. Ferrie S, Herkes R, Forrest P (2013) Nutrition support during extracorporeal membrane oxygenation (ECMO) in adults: a retrospective audit of 86 patients. Intensive Care Med 39:1989–1994. doi:10.1007/s00134-013-3053-2
  50. Papazian L, Herridge M (2013) Outcomes and risk stratification for severe ARDS treated with ECMO. Intensive Care Med 39:1857–1860. doi:10.1007/s00134-013-3067-9
  51. Abrams D, Brodie D, Combes A (2013) What is new in extracorporeal membrane oxygenation for ARDS in adults? Intensive Care Med 39:2028–2030. doi:10.1007/s00134-013-3035-4
  52. Nesseler N, Defontaine A, Launey Y et al (2013) Long-term mortality and quality of life after septic shock: a follow-up observational study. Intensive Care Med 39:881–888. doi:10.1007/s00134-013-2815-1
  53. Oeyen SG, Benoit DD, Annemans L et al (2013) Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study. Intensive Care Med 39:889–898. doi:10.1007/s00134-012-2791-x
  54. Azoulay E, Kouatchet A, Jaber S et al (2013) Noninvasive mechanical ventilation in patients having declined tracheal intubation. Intensive Care Med 39:292–301. doi:10.1007/s00134-012-2746-2
  55. Jongerden IP, Slooter AJ, Peelen LM et al (2013) Effect of intensive care environment on family and patient satisfaction: a before-after study. Intensive Care Med 39:1626–1634. doi:10.1007/s00134-013-2966-0
  56. Schwarzkopf D, Behrend S, Skupin H et al (2013) Family satisfaction in the intensive care unit: a quantitative and qualitative analysis. Intensive Care Med 39:1071–1079. doi:10.1007/s00134-013-2862-7
  57. Jones C (2013) What’s new on the post-ICU burden for patients and relatives? Intensive Care Med 39:1832–1835. doi:10.1007/s00134-013-3015-8
  58. Giannini A, Miccinesi G, Prandi E et al (2013) Partial liberalization of visiting policies and ICU staff: a before-and-after study. Intensive Care Med 39:2180–2187. doi:10.1007/s00134-013-3087-5
  59. Philippart F, Vesin A, Bruel C et al (2013) The ETHICA study (part I): elderly’s thoughts about intensive care unit admission for life-sustaining treatments. Intensive Care Med 39:1565–1573. doi:10.1007/s00134-013-2976-y
  60. Garrouste-Orgeas M, Tabah A, Vesin A et al (2013) The ETHICA study (part II): simulation study of determinants and variability of ICU physician decisions in patients aged 80 or over. Intensive Care Med 39:1574–1583. doi:10.1007/s00134-013-2977-x
  61. Wilson ME, Rhudy LM, Ballinger BA et al (2013) Factors that contribute to physician variability in decisions to limit life support in the ICU: a qualitative study. Intensive Care Med 39:1009–1018. doi:10.1007/s00134-013-2896-x
  62. Barnato AE, Tate JA, Rodriguez KL et al (2012) Norms of decision making in the ICU: a case study of two academic medical centers at the extremes of end-of-life treatment intensity. Intensive Care Med 38:1886–1896. doi:10.1007/s00134-012-2661-6
  63. Kutsogiannis DJ, Asthana S, Townsend DR et al (2013) The incidence of potential missed organ donors in intensive care units and emergency rooms: a retrospective cohort. Intensive Care Med 39:1452–1459. doi:10.1007/s00134-013-2952-6
  64. Al-Khafaji A, Murugan R, Kellum JA (2013) What’s new in organ donation: better care of the dead for the living. Intensive Care Med 39:2031–2033. doi:10.1007/s00134-013-3038-1
  65. Gigon F, Merlani P, Chenaud C, Ricou B (2013) ICU research: the impact of invasiveness on informed consent. Intensive Care Med 39:1282–1289. doi:10.1007/s00134-013-2908-x
  66. Potter JE, McKinley S, Delaney A (2013) Research participants’ opinions of delayed consent for a randomised controlled trial of glucose control in intensive care. Intensive Care Med 39:472–480. doi:10.1007/s00134-012-2732-8
  67. Kompanje EJO (2013) Strong words, but still a step back for researchers in emergency and critical care research? The proposed revision of the Declaration of Helsinki. Intensive Care Med 39:1469–1470. doi:10.1007/s00134-013-2988-7
  68. Cook D, Arabi Y, Ferguson N et al (2013) Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med 39:2115–2125. doi:10.1007/s00134-013-3074-x
  69. Sprung CL, Danis M, Iapichino G et al (2013) Triage of intensive care patients: identifying agreement and controversy. Intensive Care Med 39:1916–1924. doi:10.1007/s00134-013-3033-6
  70. Garrouste-Orgeas M, Valentin A (2013) What’s new for patient safety in the ICU? Intensive Care Med 39:1829–1831. doi:10.1007/s00134-013-3013-x
  71. Valentin A, Schiffinger M, Steyrer J et al (2013) Safety climate reduces medication and dislodgement errors in routine intensive care practice. Intensive Care Med 39:391–398. doi:10.1007/s00134-012-2764-0
  72. De Jonghe B, Constantin J-M, Chanques G et al (2013) Physical restraint in mechanically ventilated ICU patients: a survey of French practice. Intensive Care Med 39:31–37. doi:10.1007/s00134-012-2715-9
  73. Pelieu I, Djadi-Prat J, Consoli SM et al (2013) Impact of organizational culture on preventability assessment of selected adverse events in the ICU: evaluation of morbidity and mortality conferences. Intensive Care Med 39:1214–1220. doi:10.1007/s00134-013-2923-y
  74. Ten Have ECM, Nap RE, Tulleken JE (2013) Quality improvement of interdisciplinary rounds by leadership training based on essential quality indicators of the Interdisciplinary Rounds Assessment Scale. Intensive Care Med 39:1800–1807. doi:10.1007/s00134-013-3002-0
  75. Kahn JM (2013) What’s new in ICU volume-outcome relationships? Intensive Care Med 39:1635–1637. doi:10.1007/s00134-013-2992-y
  76. Latronico N, Metelli M, Turin M et al (2013) Quality of reporting of randomized controlled trials published in Intensive Care Medicine from 2001 to 2010. Intensive Care Med 39:1386–1395. doi:10.1007/s00134-013-2947-3
  77. Vesin A, Azoulay E, Ruckly S et al (2013) Reporting and handling missing values in clinical studies in intensive care units. Intensive Care Med 39:1396–1404. doi:10.1007/s00134-013-2949-1
  78. Awissi D-K, Lebrun G, Coursin DB et al (2013) Alcohol withdrawal and delirium tremens in the critically ill: a systematic review and commentary. Intensive Care Med 39:16–30. doi:10.1007/s00134-012-2758-y
  79. Drolz A, Jaeger B, Wewalka M et al (2013) Clinical impact of arterial ammonia levels in ICU patients with different liver diseases. Intensive Care Med 39:1227–1237. doi:10.1007/s00134-013-2926-8
  80. Thiolliere F, Serre-Sapin AF, Reignier J et al (2013) Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study. Intensive Care Med 39:1460–1468. doi:10.1007/s00134-013-2963-3
  81. De Blasi RA, Cardelli P, Costante A et al (2013) Immature platelet fraction in predicting sepsis in critically ill patients. Intensive Care Med 39:636–643. doi:10.1007/s00134-012-2725-7
  82. Mariotte E, Blet A, Galicier L et al (2013) Unresponsive thrombotic thrombocytopenic purpura in critically ill adults. Intensive Care Med 39:1272–1281. doi:10.1007/s00134-013-2873-4
  83. Vincent J-L, Hajjar LA (2013) What’s new in transfusion policies? Intensive Care Med 39:1002–1004. doi:10.1007/s00134-013-2900-5
  84. Kahn SR (2012) Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. CHEST J 141:e195S. doi:10.1378/chest.11-2296
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  85. Vignon P, Dequin P-F, Renault A et al (2013) Intermittent pneumatic compression to prevent venous thromboembolism in patients with high risk of bleeding hospitalized in intensive care units: the CIREA1 randomized trial. Intensive Care Med 39:872–880. doi:10.1007/s00134-013-2814-2
  86. Matějková S, Scheuerle A, Wagner F et al (2013) Carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine kidney ischemia/reperfusion injury. Intensive Care Med 39:497–510. doi:10.1007/s00134-012-2766-y
  87. Mesgarpour B, Heidinger BH, Schwameis M et al (2013) Safety of off-label erythropoiesis stimulating agents in critically ill patients: a meta-analysis. Intensive Care Med 39:1896–1908. doi:10.1007/s00134-013-3030-9

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