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Year in review in Intensive Care Medicine 2010: II. Pneumonia and infections, cardiovascular and haemodynamics, organization, education, haematology, nutrition, ethics and miscellaneaOpen access

Massimo Antonelli| Elie Azoulay| Marc Bonten| Jean Chastre| Giuseppe Citerio| Giorgio Conti| Daniel De Backer| Herwig Gerlach| Goran Hedenstierna| Michael Joannidis| Duncan Macrae| Jordi Mancebo| Salvatore M. Maggiore| Alexandre Mebazaa| Jean-Charles Preiser| Jerôme Pugin| Jan Wernerman| Haibo Zhang
Year in Review 2010
Volume 37, Issue 2 / February , 2011

Pages 196 - 213

No abstract available.


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  2. Claessens YE, Mathevon T, Kierzek G, Grabar S, Jegou D, Batard E, Loyer C, Davido A, Hausfater P, Robert H, Lavagna-Perez L, Bernot B, Plaisance P, Leroy C, Renaud B (2010) Accuracy of C-reactive protein, procalcitonin, and mid-regional pro-atrial natriuretic peptide to guide site of care of community-acquired pneumonia. Intensive Care Med 36:799–809
  3. Mongardon N, Lemiale V, Perbet S, Dumas F, Legriel S, Guerin S, Charpentier J, Chiche JD, Mira JP, Cariou A (2010) Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patients. Intensive Care Med 36:92–99
  4. Jung B, Embriaco N, Roux F, Forel JM, Demory D, Allardet-Servent J, Jaber S, La Scola B, Papazian L (2010) Microbiogical data, but not procalcitonin improve the accuracy of the clinical pulmonary infection score. Intensive Care Med 36:790–798
  5. Tessmer A, Welte T, Martus P, Schnoor M, Marre R, Suttorp N (2009) Impact of intravenous β-lactam/macrolide versus β-lactam monotherapy on mortality in hospitalized patients with community-acquired pneumonia. J Antimicrob Chemother 63:1025–1033
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  6. Martin-Loeches I, Lisboa T, Rodriguez A, Putensen C, Annane D, Garnacho-Montero J, Restrepo MI, Rello J (2010) Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med 36:612–620
  7. Snijders D, Daniels JM, de Graaff CS, van der Werf TS, Boersma WG (2010) Efficacy of corticosteroids in community-acquired pneumonia: a randomized double-blinded clinical trial. Am J Respir Crit Care Med 181:975–982
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  8. Dominguez-Cherit G, Lapinsky SE, Macias AE, Pinto R, Espinosa-Perez L, de la Torre A, Poblano-Morales M, Baltazar-Torres JA, Bautista E, Martinez A, Martinez MA, Rivero E, Valdez R, Ruiz-Palacios G, Hernandez M, Stewart TE, Fowler RA (2009) Critically ill patients with 2009 influenza A(H1N1) in Mexico. JAMA 302:1880–1887
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  9. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA (2009) Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA 302:1872–1879
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  10. Quispe-Laime AM, Bracco JD, Barberio PA, Campagne CG, Rolfo VE, Umberger R, Meduri GU (2010) H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment. Intensive Care Med 36:33–41
  11. Namendys-Silva SA, Hernandez-Garay M (2010) Hydrocortisone therapy for patients with H1N1 influenza A infection. Intensive Care Med 36:1097 (author reply 1100–1101)
  12. Salluh JI, Povoa P (2010) Corticosteroids for H1N1 associated acute lung injury: is it just wishful thinking? Intensive Care Med 36:1098–1099 (author reply 1100–1101)
  13. Benus RF, Harmsen HJ, Welling GW, Spanjersberg R, Zijlstra JG, Degener JE, van der Werf TS (2010) Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients. Intensive Care Med 36:1394–1402
  14. de Smet AM, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS, van der Hoeven JG, Pickkers P, Bogaers-Hofman D, van der Meer NJ, Bernards AT, Kuijper EJ, Joore JC, Leverstein-van Hall MA, Bindels AJ, Jansz AR, Wesselink RM, de Jongh BM, Dennesen PJ, van Asselt GJ, te Velde LF, Frenay IH, Kaasjager K, Bosch FH, van Iterson M, Thijsen SF, Kluge GH, Pauw W, de Vries JW, Kaan JA, Arends JP, Aarts LP, Sturm PD, Harinck HI, Voss A, Uijtendaal EV, Blok HE, Thieme Groen ES, Pouw ME, Kalkman CJ, Bonten MJ (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20–31
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  15. Oostdijk EA, de Smet AM, Blok HE, Thieme Groen ES, van Asselt GJ, Benus RF, Bernards SA, Frenay IH, Jansz AR, de Jongh BM, Kaan JA, Leverstein-van Hall MA, Mascini EM, Pauw W, Sturm PD, Thijsen SF, Kluytmans JA, Bonten MJ (2010) Ecological effects of selective decontamination on resistant gram-negative bacterial colonization. Am J Respir Crit Care Med 181:452–457
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  16. Bouadma L, Mourvillier B, Deiler V, Derennes N, Le Corre B, Lolom I, Regnier B, Wolff M, Lucet JC (2010) Changes in knowledge, beliefs, and perceptions throughout a multifaceted behavioral program aimed at preventing ventilator-associated pneumonia. Intensive Care Med 36:1341–1347
  17. Lorente L, Lecuona M, Jimenez A, Mora ML, Sierra A (2007) Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am J Respir Crit Care Med 176:1079–1083
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  18. Nseir S, Zerimech F, De Jonckheere J, Alves I, Balduyck M, Durocher A (2010) Impact of polyurethane on variations in tracheal cuff pressure in critically ill patients: a prospective observational study. Intensive Care Med 36:1156–1163
  19. Coffin SE, Klompas M, Classen D, Arias KM, Podgorny K, Anderson DJ, Burstin H, Calfee DP, Dubberke ER, Fraser V, Gerding DN, Griffin FA, Gross P, Kaye KS, Lo E, Marschall J, Mermel LA, Nicolle L, Pegues DA, Perl TM, Saint S, Salgado CD, Weinstein RA, Wise R, Yokoe DS (2008) Strategies to prevent ventilator-associated pneumonia in acute care hospitals. Infect Control Hosp Epidemiol 29(Suppl 1):S31–S40
  20. Kohlenberg A, Schwab F, Behnke M, Geffers C, Gastmeier P (2010) Pneumonia associated with invasive and noninvasive ventilation: an analysis of the German nosocomial infection surveillance system database. Intensive Care Med 36:971–978
  21. Rello J, Lode H, Cornaglia G, Masterton R (2010) A European care bundle for prevention of ventilator-associated pneumonia. Intensive Care Med 36:773–780
  22. Garcin F, Leone M, Antonini F, Charvet A, Albanese J, Martin C (2010) Non-adherence to guidelines: an avoidable cause of failure of empirical antimicrobial therapy in the presence of difficult-to-treat bacteria. Intensive Care Med 36:75–82
  23. Lu Q, Girardi C, Zhang M, Bouhemad B, Louchahi K, Petitjean O, Wallet F, Becquemin MH, Le Naour G, Marquette CH, Rouby JJ (2010) Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa. Intensive Care Med 36:1147–1155
  24. Ferrari F, Lu Q, Girardi C, Petitjean O, Marquette CH, Wallet F, Rouby JJ (2009) Nebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosa. Intensive Care Med 35:1792–1800
  25. Sheu CC, Gong MN, Zhai R, Bajwa EK, Chen F, Thompson BT, Christiani DC (2010) The influence of infection sites on development and mortality of ARDS. Intensive Care Med 36:963–970
  26. Melsen WG, Rovers MM, Bonten MJ (2009) Ventilator-associated pneumonia and mortality: a systematic review of observational studies. Crit Care Med 37:2709–2718
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  27. Nguile-Makao M, Zahar JR, Francais A, Tabah A, Garrouste-Orgeas M, Allaouchiche B, Goldgran-Toledano D, Azoulay E, Adrie C, Jamali S, Clec’h C, Souweine B, Timsit JF (2010) Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models. Intensive Care Med 36:781–789
  28. Schumacher M, Wangler M, Wolkewitz M, Beyersmann J (2007) Attributable mortality due to nosocomial infections. A simple and useful application of multistate models. Methods Inf Med 46:595–600
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  29. Lehmann LE, Hunfeld KP, Steinbrucker M, Brade V, Book M, Seifert H, Bingold T, Hoeft A, Wissing H, Stuber F (2010) Improved detection of blood stream pathogens by real-time PCR in severe sepsis. Intensive Care Med 36:49–56
  30. Bloos F, Hinder F, Becker K, Sachse S, Mekontso Dessap A, Straube E, Cattoir V, Brun-Buisson C, Reinhart K, Peters G, Bauer M (2010) A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis. Intensive Care Med 36:241–247
  31. Simons KS, Pickkers P, Bleeker-Rovers CP, Oyen WJ, van der Hoeven JG (2010) F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection. Intensive Care Med 36:504–511
  32. Nijssen S, Fluit A, van de Vijver D, Top J, Willems R, Bonten MJ (2010) Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteria. Intensive Care Med 36:512–519
  33. Ananda-Rajah MR, McBryde ES, Buising KL, Redl L, Macisaac C, Cade JF, Marshall C (2010) The role of general quality improvement measures in decreasing the burden of endemic MRSA in a medical-surgical intensive care unit. Intensive Care Med 36:1890–1898
  34. Popovich KJ, Hota B, Hayes R, Weinstein RA, Hayden MK (2010) Daily skin cleansing with chlorhexidine did not reduce the rate of central-line associated bloodstream infection in a surgical intensive care unit. Intensive Care Med 36:854–858
  35. Sprung CL, Zimmerman JL, Christian MD, Joynt GM, Hick JL, Taylor B, Richards GA, Sandrock C, Cohen R, Adini B (2010) Recommendations for intensive care unit and hospital preparations for an influenza epidemic or mass disaster: summary report of the European Society of Intensive Care Medicine’s Task Force for intensive care unit triage during an influenza epidemic or mass disaster. Intensive Care Med 36:428–443
  36. Ingram PR, Inglis T, Moxon D, Speers D (2010) Procalcitonin and C-reactive protein in severe 2009 H1N1 influenza infection. Intensive Care Med 36:528–532
  37. Pletz MW, Bloos F, Burkhardt O, Brunkhorst FM, Bode-Boger SM, Martens-Lobenhoffer J, Greer MW, Stass H, Welte T (2010) Pharmacokinetics of moxifloxacin in patients with severe sepsis or septic shock. Intensive Care Med 36:979–983
  38. Burgmann H, Hiesmayr JM, Savey A, Bauer P, Metnitz B, Metnitz PG (2010) Impact of nosocomial infections on clinical outcome and resource consumption in critically ill patients. Intensive Care Med 36:1597–1601
  39. Landelle C, Lepape A, Voirin N, Tognet E, Venet F, Bohe J, Vanhems P, Monneret G (2010) Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med 36:1859–1866
  40. Ospina-Tascon G, Neves AP, Occhipinti G, Donadello K, Buchele G, Simion D, Chierego ML, Silva TO, Fonseca A, Vincent JL, De Backer D (2010) Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med 36:949–955
  41. Maybauer MO, Walley KR (2010) Best vasopressor for advanced vasodilatory shock: should vasopressin be part of the mix? Intensive Care Med 36:1484–1487
  42. Torgersen C, Dunser MW, Wenzel V, Jochberger S, Mayr V, Schmittinger CA, Lorenz I, Schmid S, Westphal M, Grander W, Luckner G (2010) Comparing two different arginine vasopressin doses in advanced vasodilatory shock: a randomized, controlled, open-label trial. Intensive Care Med 36:57–65
  43. Muller L, Louart G, Bousquet PJ, Candela D, Zoric L, de La Coussaye JE, Jaber S, Lefrant JY (2010) The influence of the airway driving pressure on pulsed pressure variation as a predictor of fluid responsiveness. Intensive Care Med 36:496–503
  44. Mercado-Martinez J, Rivera-Fernandez R, Aguilar-Alonso E, Garcia-Alcantara A, Estivill-Torrull A, Aranda-Leon A, Guia-Rambla MC, Fuset-Cabanes MP (2010) APACHE-II score and Killip class for patients with acute myocardial infarction. Intensive Care Med 36:1579–1586
  45. Monnet X, Teboul JL (2008) Passive leg raising. Intensive Care Med 34:659–663
  46. Jabot J, Teboul JL, Richard C, Monnet X (2009) Passive leg raising for predicting fluid responsiveness: importance of the postural change. Intensive Care Med 35:85–90
  47. Lakhal K, Ehrmann S, Runge I, Benzekri-Lefevre D, Legras A, Dequin PF, Mercier E, Wolff M, Regnier B, Boulain T (2010) Central venous pressure measurements improve the accuracy of leg raising-induced change in pulse pressure to predict fluid responsiveness. Intensive Care Med 36:940–948
  48. Benomar B, Ouattara A, Estagnasie P, Brusset A, Squara P (2010) Fluid responsiveness predicted by noninvasive bioreactance-based passive leg raise test. Intensive Care Med 36:1875–1881
  49. Guiotto G, Masarone M, Paladino F, Ruggiero E, Scott S, Verde S, Schiraldi F (2010) Inferior vena cava collapsibility to guide fluid removal in slow continuous ultrafiltration: a pilot study. Intensive Care Med 36:692–696
  50. Cavallaro F, Sandroni C, Marano C, La Torre G, Mannocci A, De Waure C, Bello G, Maviglia R, Antonelli M (2010) Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studies. Intensive Care Med 36:1475–1483
  51. Galstyan G, Bychinin M, Alexanyan M, Gorodetsky V (2010) Comparison of cardiac output and blood volumes in intrathoracic compartments measured by ultrasound dilution and transpulmonary thermodilution methods. Intensive Care Med 36:2140–2144
  52. Trof RJ, Sukul SP, Twisk JW, Girbes AR, Groeneveld AB (2010) Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia. Intensive Care Med 36:697–701
  53. Schortgen F, Girou E, Deye N, Brochard L (2010) Do hypooncotic fluids for shock increase the risk of late-onset acute respiratory distress syndrome? Intensive Care Med 36:1724–1734
  54. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL (2002) Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98–104
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  55. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM (2008) Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 34:2210–2217
  56. Boldt J, Ince C (2010) The impact of fluid therapy on microcirculation and tissue oxygenation in hypovolemic patients: a review. Intensive Care Med 36:1299–1308
  57. Pottecher J, Deruddre S, Teboul JL, Georger JF, Laplace C, Benhamou D, Vicaut E, Duranteau J (2010) Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients. Intensive Care Med 36:1867–1874
  58. Hollenberg SM (2010) Think locally: evaluation of the microcirculation in sepsis. Intensive Care Med 36:1807–1809
  59. Georger JF, Hamzaoui O, Chaari A, Maizel J, Richard C, Teboul JL (2010) Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients. Intensive Care Med 36:1882–1889
  60. Rhodes A, Cecconi M, Hamilton M, Poloniecki J, Woods J, Boyd O, Bennett D, Grounds RM (2010) Goal-directed therapy in high-risk surgical patients: a 15-year follow-up study. Intensive Care Med 36:1327–1332
  61. Duchateau FX, Gueye P, Curac S, Tubach F, Broche C, Plaisance P, Payen D, Mantz J, Ricard-Hibon A (2010) Effect of the AutoPulse automated band chest compression device on hemodynamics in out-of-hospital cardiac arrest resuscitation. Intensive Care Med 36:1256–1260
  62. Konrad D, Jaderling G, Bell M, Granath F, Ekbom A, Martling CR (2010) Reducing in-hospital cardiac arrests and hospital mortality by introducing a medical emergency team. Intensive Care Med 36:100–106
  63. Kuijsten HA, Brinkman S, Meynaar IA, Spronk PE, van der Spoel JI, Bosman RJ, de Keizer NF, Abu-Hanna A, de Lange DW (2010) Hospital mortality is associated with ICU admission time. Intensive Care Med 36:1765–1771
  64. Seguin P, Laviolle B, Isslame S, Coue A, Malledant Y (2010) Effectiveness of simple daily sensitization of physicians to the duration of central venous and urinary tract catheterization. Intensive Care Med 36:1202–1206
  65. Zwart JJ, Dupuis JR, Richters A, Ory F, van Roosmalen J (2010) Obstetric intensive care unit admission: a 2-year nationwide population-based cohort study. Intensive Care Med 36:256–263
  66. Mercier E, Giraudeau B, Ginies G, Perrotin D, Dequin PF (2010) Iatrogenic events contributing to ICU admission: a prospective study. Intensive Care Med 36:1033–1037
  67. Ford DG, Seybert AL, Smithburger PL, Kobulinsky LR, Samosky JT, Kane-Gill SL (2010) Impact of simulation-based learning on medication error rates in critically ill patients. Intensive Care Med 36:1526–1531
  68. Gorman SK, Chung MH, Slavik RS, Zed PJ, Wilbur K, Dhingra VK (2010) A critical appraisal of the quality of critical care pharmacotherapy clinical practice guidelines and their strength of recommendations. Intensive Care Med 36:1636–1643
  69. Sprung CL, Cohen R, Adini B (2010) Chapter 1. Introduction. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):S4–S10
  70. Hick JL, Christian MD, Sprung CL (2010) Chapter 2. Surge capacity and infrastructure considerations for mass critical care. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):S11–S20
  71. Joynt GM, Loo S, Taylor BL, Margalit G, Christian MD, Sandrock C, Danis M, Leoniv Y, Sprung CL (2010) Chapter 3. Coordination and collaboration with interface units. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):S21–S31
  72. Sandrock C (2010) Chapter 4. Manpower. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):S32–S37
  73. Sprung CL, Kesecioglu J (2010) Chapter 5. Essential equipment, pharmaceuticals and supplies. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):S38–S44
  74. Taylor BL, Montgomery HE, Rhodes A, Sprung CL (2010) Chapter 6. Protection of patients and staff during a pandemic. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):45–54
  75. Christian MD, Joynt GM, Hick JL, Colvin J, Danis M, Sprung CL (2010) Chapter 7. Critical care triage. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(Suppl 1):S55–S64
  76. Zimmerman JL, Sprung CL (2010) Chapter 8. Medical procedures. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(1):65–69
  77. Richards GA, Sprung CL (2010) Chapter 9. Educational process. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster. Intensive Care Med 36(1):70–79
  78. Polverino E, Nava S, Ferrer M, Ceriana P, Clini E, Spada E, Zanotti E, Trianni L, Barbano L, Fracchia C, Balbi B, Vitacca M (2010) Patients’ characterization, hospital course and clinical outcomes in five Italian respiratory intensive care units. Intensive Care Med 36:137–142
  79. Kalfon P, Mimoz O, Auquier P, Loundou A, Gauzit R, Lepape A, Laurens J, Garrigues B, Pottecher T, Malledant Y (2010) Development and validation of a questionnaire for quantitative assessment of perceived discomforts in critically ill patients. Intensive Care Med 36:1751–1758
  80. Vainiola T, Pettila V, Roine RP, Rasanen P, Rissanen AM, Sintonen H (2010) Comparison of two utility instruments, the EQ-5D and the 15D, in the critical care setting. Intensive Care Med 36:2090–2093
  81. The CoBaTrICE Collaboration (2010) International standards for programmes of training in intensive care medicine in Europe. Intensive Care Med. doi:10.1007/s00134-010-2096-x
  82. van Mook WN, de Grave WS, Gorter SL, Muijtjens AM, Zwaveling JH, Schuwirth LW, van der Vleuten CP (2010) Fellows’ in intensive care medicine views on professionalism and how they learn it. Intensive Care Med 36:296–303
  83. Sandroni C, Gonnella GL, de Waure C, Cavallaro F, Torre GL, Antonelli M (2010) Which factors predict candidate outcome in advanced life support courses? A preliminary observational study. Intensive Care Med 36:1521–1525
  84. Reade MC, Delaney A, Bailey MJ, Harrison DA, Yealy DM, Jones PG, Rowan KM, Bellomo R, Angus DC (2010) Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med 36:11–21
  85. Kalil AC (2010) Wanted: early goal-directed therapy for septic shock–dead or alive, but not critically ill! Intensive Care Med 36:1–3
  86. Gayat E, Pirracchio R, Resche-Rigon M, Mebazaa A, Mary JY, Porcher R (2010) Propensity scores in intensive care and anaesthesiology literature: a systematic review. Intensive Care Med 36:1993–2003
  87. Westbrook A, Pettila V, Nichol A, Bailey MJ, Syres G, Murray L, Bellomo R, Wood E, Phillips LE, Street A, French C, Orford N, Santamaria J, Cooper DJ (2010) Transfusion practice and guidelines in Australian and New Zealand intensive care units. Intensive Care Med 36:1138–1146
  88. Vandijck DM, Depuydt PO, Offner FC, Nollet J, Peleman RA, Steel E, Noens LA, Decruyenaere JM, Benoit DD (2010) Impact of organ dysfunction on mortality in ICU patients with hematologic malignancies. Intensive Care Med 36:1744–1750
  89. Buyse S, Teixeira L, Galicier L, Mariotte E, Lemiale V, Seguin A, Bertheau P, Canet E, de Labarthe A, Darmon M, Rybojad M, Schlemmer B, Azoulay E (2010) Critical care management of patients with hemophagocytic lymphohistiocytosis. Intensive Care Med 36:1695–1702
  90. Squadrone V, Massaia M, Bruno B, Marmont F, Falda M, Bagna C, Bertone S, Filippini C, Slutsky AS, Vitolo U, Boccadoro M, Ranieri VM (2010) Early CPAP prevents evolution of acute lung injury in patients with hematologic malignancy. Intensive Care Med 36:1666–1674
  91. Montejo JC, Minambres E, Bordeje L, Mesejo A, Acosta J, Heras A, Ferre M, Fernandez-Ortega F, Vaquerizo CI, Manzanedo R (2010) Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med 36:1386–1393
  92. Acosta-Escribano J, Fernandez-Vivas M, Grau Carmona T, Caturla-Such J, Garcia-Martinez M, Menendez-Mainer A, Solera-Suarez M, Sanchez-Paya J (2010) Gastric versus transpyloric feeding in severe traumatic brain injury: a prospective, randomized trial. Intensive Care Med 36:1532–1539
  93. Barraud D, Blard C, Hein F, Marcon O, Cravoisy A, Nace L, Alla F, Bollaert PE, Gibot S (2010) Probiotics in the critically ill patient: a double blind, randomized, placebo-controlled trial. Intensive Care Med 36:1540–1547
  94. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJ (2010) Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intensive Care Med 36:735–749
  95. Piton G, Manzon C, Monnet E, Cypriani B, Barbot O, Navellou JC, Carbonnel F, Capellier G (2010) Plasma citrulline kinetics and prognostic value in critically ill patients. Intensive Care Med 36:702–706
  96. Lindner G, Funk GC, Lassnigg A, Mouhieddine M, Ahmad SA, Schwarz C, Hiesmayr M (2010) Intensive care-acquired hypernatremia after major cardiothoracic surgery is associated with increased mortality. Intensive Care Med 36:1718–1723
  97. Lasocki S, Baron G, Driss F, Westerman M, Puy H, Boutron I, Beaumont C, Montravers P (2010) Diagnostic accuracy of serum hepcidin for iron deficiency in critically ill patients with anemia. Intensive Care Med 36:1044–1048
  98. Andreasen AS, Pedersen-Skovsgaard T, Berg RM, Svendsen KD, Feldt-Rasmussen B, Pedersen BK, Moller K (2010) Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia. Intensive Care Med 36:1548–1555
  99. Pittet YK, Berger MM, Pluess TT, Voirol P, Revelly JP, Tappy L, Chiolero RL (2010) Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil. Intensive Care Med 36:289–295
  100. Eastman N, Philips B, Rhodes A (2010) Triaging for adult critical care in the event of overwhelming need. Intensive Care Med 36:1076–1082
  101. Tillyard A (2010) Reorganising the pandemic triage processes to ethically maximise individuals’ best interests. Intensive Care Med 36:1966–1971
  102. Le Conte P, Riochet D, Batard E, Volteau C, Giraudeau B, Arnaudet I, Labastire L, Levraut J, Thys F, Lauque D, Piva C, Schmidt J, Trewick D, Potel G (2010) Death in emergency departments: a multicenter cross-sectional survey with analysis of withholding and withdrawing life support. Intensive Care Med 36:765–772
  103. Jansen TC, Bakker J, Kompanje EJ (2010) Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results. Intensive Care Med 36:1962–1965
  104. de Groot YJ, Jansen NE, Bakker J, Kuiper MA, Aerdts S, Maas AI, Wijdicks EF, van Leiden HA, Hoitsma AJ, Kremer BH, Kompanje EJ (2010) Imminent brain death: point of departure for potential heart-beating organ donor recognition. Intensive Care Med 36:1488–1494
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