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Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentalsOpen access

Massimo Antonelli| Elie Azoulay| Marc Bonten| Jean Chastre| Giuseppe Citerio| Giorgio Conti| Daniel De Backer| Herwig Gerlach| Goran Hedenstierna| Michael Joannidis| Duncan Macrae| Jordi Mancebo| Salvatore M. Maggiore| Alexandre Mebazaa| Jean-Charles Preiser| Jerôme Pugin| Jan Wernerman| Haibo Zhang
Year in Review 2010
Volume 37, Issue 1 / January , 2011

Pages 19 - 34

No abstract available.


  1. Joannidis M, Druml W, Forni LG, Groeneveld AB, Honore P, Oudemans-van Straaten HM, Ronco C, Schetz MR, Woittiez AJ (2010) Prevention of acute kidney injury and protection of renal function in the intensive care unit. expert opinion of the working group for nephrology, ESICM. Intensive Care Med 36:392–411
  2. Wiedermann CJ, Wiedermann W, Joannidis M (2010) Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies. Intensive Care Med 36:1657–1665
  3. Brusselaers N, Monstrey S, Colpaert K, Decruyenaere J, Blot SI, Hoste EA (2010) Outcome of acute kidney injury in severe burns: a systematic review and meta-analysis. Intensive Care Med 36:915–925
  4. Chronopoulos A, Rosner MH, Cruz DN, Ronco C (2010) Acute kidney injury in elderly intensive care patients: a review. Intensive Care Med 36:1454–1464
  5. Kumpers P, Hafer C, David S, Hecker H, Lukasz A, Fliser D, Haller H, Kielstein JT, Faulhaber-Walter R (2010) Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome. Intensive Care Med 36:462–470
  6. Cruz DN, de Cal M, Garzotto F, Perazella MA, Lentini P, Corradi V, Piccinni P, Ronco C (2010) Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population. Intensive Care Med 36:444–451
  7. Bagshaw SM, Bennett M, Haase M, Haase-Fielitz A, Egi M, Morimatsu H, D’Amico G, Goldsmith D, Devarajan P, Bellomo R (2010) Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 36:452–461
  8. Martensson J, Bell M, Oldner A, Xu S, Venge P, Martling CR (2010) Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury. Intensive Care Med 36:1333–1340
  9. Bouman CS, Forni LG, Joannidis M (2010) Biomarkers and acute kidney injury: dining with the fisher king? Intensive Care Med 36:381–384
  10. Lerolle N, Nochy D, Guerot E, Bruneval P, Fagon JY, Diehl JL, Hill G (2010) Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med 36:471–478
  11. Albanese J, Leone M, Delmas A, Martin C (2005) Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study. Crit Care Med 33:1897–1902
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  12. Gordon AC, Russell JA, Walley KR, Singer J, Ayers D, Storms MM, Holmes CL, Hebert PC, Cooper DJ, Mehta S, Granton JT, Cook DJ, Presneill JJ (2010) The effects of vasopressin on acute kidney injury in septic shock. Intensive Care Med 36:83–91
  13. Druml W, Metnitz B, Schaden E, Bauer P, Metnitz PG (2010) Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapy. Intensive Care Med 36:1221–1228
  14. Sakr Y, Madl C, Filipescu D, Moreno R, Groeneveld J, Artigas A, Reinhart K, Vincent JL (2008) Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med 34:1999–2009
  15. Joannidis M, Oudemans-van Straaten HM (2007) Clinical review: patency of the circuit in continuous renal replacement therapy. Crit Care 11:218
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  17. Mariano F, Tedeschi L, Morselli M, Stella M, Triolo G (2010) Normal citratemia and metabolic tolerance of citrate anticoagulation for hemodiafiltration in severe septic shock burn patients. Intensive Care Med 36:1735–1743
  18. Iapichino G, Corbella D, Minelli C, Mills GH, Artigas A, Edbooke DL, Pezzi A, Kesecioglu J, Patroniti N, Baras M, Sprung CL (2010) Reasons for refusal of admission to intensive care and impact on mortality. Intensive Care Med 36:1772–1779
  19. Fernandez R, Baigorri F, Navarro G, Artigas A (2006) A modified McCabe score for stratification of patients after intensive care unit discharge: the Sabadell score. Crit Care 10:R179
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  20. Fernandez R, Serrano JM, Umaran I, Abizanda R, Carrillo A, Lopez-Pueyo MJ, Rascado P, Balerdi B, Suberviola B, Hernandez G (2010) Ward mortality after ICU discharge: a multicenter validation of the Sabadell score. Intensive Care Med 36:1196–1201
  21. Metnitz PG, Metnitz B, Moreno RP, Bauer P, Del Sorbo L, Hoermann C, de Carvalho SA, Ranieri VM (2009) Epidemiology of mechanical ventilation: analysis of the SAPS 3 database. Intensive Care Med 35:816–825
  22. Soares M, Silva UV, Teles JM, Silva E, Caruso P, Lobo SM, Dal Pizzol F, Azevedo LP, de Carvalho FB, Salluh JI (2010) Validation of four prognostic scores in patients with cancer admitted to Brazilian intensive care units: results from a prospective multicenter study. Intensive Care Med 36:1188–1195
  23. Strand K, Strand LI, Flaatten H (2010) The interrater reliability of SAPS II and SAPS 3. Intensive Care Med 36:850–853
  24. Csomos A, Varga S, Bertolini G, Hibbert C, Sandor J, Capuzzo M, Guidet BR (2010) Intensive care reimbursement practices: results from the ICUFUND survey. Intensive Care Med 36:1759–1764
  25. Moreno RP, Hochrieser H, Metnitz B, Bauer P, Metnitz PG (2010) Characterizing the risk profiles of intensive care units. Intensive Care Med 36:1207–1212
  26. Eslami S, Abu-Hanna A, de Keizer NF, Bosman RJ, Spronk PE, de Jonge E, Schultz MJ (2010) Implementing glucose control in intensive care: a multicenter trial using statistical process control. Intensive Care Med 36:1556–1565
  27. Campion TR Jr, May AK, Waitman LR, Ozdas A, Gadd CS (2010) Effects of blood glucose transcription mismatches on a computer-based intensive insulin therapy protocol. Intensive Care Med 36:1566–1570
  28. Bertsche T, Pfaff J, Schiller P, Kaltschmidt J, Pruszydlo MG, Stremmel W, Walter-Sack I, Haefeli WE, Encke J (2010) Prevention of adverse drug reactions in intensive care patients by personal intervention based on an electronic clinical decision support system. Intensive Care Med 36:665–672
  29. Reinikainen M, Karlsson S, Varpula T, Parviainen I, Ruokonen E, Varpula M, Ala-Kokko T, Pettila V (2010) Are small hospitals with small intensive care units able to treat patients with severe sepsis? Intensive Care Med 36:673–679
  30. Bryland A, Broman M, Erixon M, Klarin B, Linden T, Friberg H, Wieslander A, Kjellstrand P, Ronco C, Carlsson O, Godaly G (2010) Infusion fluids contain harmful glucose degradation products. Intensive Care Med 36:1213–1220
  31. Hausfater P, Megarbane B, Dautheville S, Patzak A, Andronikof M, Santin A, Andre S, Korchia L, Terbaoui N, Kierzek G, Doumenc B, Leroy C, Riou B (2010) Prognostic factors in non-exertional heatstroke. Intensive Care Med 36:272–280
  32. Funk GC, Lindner G, Druml W, Metnitz B, Schwarz C, Bauer P, Metnitz PG (2010) Incidence and prognosis of dysnatremias present on ICU admission. Intensive Care Med 36:304–311
  33. Sharshar T, Bastuji-Garin S, De Jonghe B, Stevens RD, Polito A, Maxime V, Rodriguez P, Cerf C, Outin H, Touraine P, Laborde K (2010) Hormonal status and ICU-acquired paresis in critically ill patients. Intensive Care Med 36:1318–1326
  34. Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC (2010) The surviving sepsis campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 36:222–231
  35. Mauri T, Bellani G, Patroniti N, Coppadoro A, Peri G, Cuccovillo I, Cugno M, Iapichino G, Gattinoni L, Pesenti A, Mantovani A (2010) Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality. Intensive Care Med 36:621–629
  36. Hoogerwerf JJ, Tanck MW, van Zoelen MA, Wittebole X, Laterre PF, van der Poll T (2010) Soluble ST2 plasma concentrations predict mortality in severe sepsis. Intensive Care Med 36:630–637
  37. Leaver SK, MacCallum NS, Pingle V, Hacking MB, Quinlan GJ, Evans TW, Burke-Gaffney A (2010) Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor. Intensive Care Med 36:336–341
  38. Takaki S, Takeyama N, Kajita Y, Yabuki T, Noguchi H, Miki Y, Inoue Y, Nakagawa T (2010) Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shock. Intensive Care Med 36:42–48
  39. Gu W, Zeng L, Zhou J, Jiang DP, Zhang L, Du DY, Hu P, Chen K, Liu Q, Wang ZG, Jiang JX (2010) Clinical relevance of 13 cytokine gene polymorphisms in Chinese major trauma patients. Intensive Care Med 36:1261–1265
  40. Kwon YS, Suh GY, Jeon K, Park SY, Lim SY et al (2010) Serum cytokines and critical illness-related corticosteroid insufficiency. Intensive Care Med 36:1845–1851
  41. Levy B, Perez P, Gibot S, Gerard A (2010) Increased muscle-to-serum lactate gradient predicts progression towards septic shock in septic patients. Intensive Care Med 36:1703–1709
  42. Creagh-Brown BC, Quinlan GJ, Evans TW, Burke-Gaffney A (2010) The RAGE axis in systemic inflammation, acute lung injury and myocardial dysfunction: an important therapeutic target? Intensive Care Med 36:1644–1656
  43. Lorne E, Dupont H, Abraham E (2010) Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med 36:1826–1835
  44. Jaecklin T, Otulakowski G, Kavanagh BP (2010) Do soluble mediators cause ventilator-induced lung injury and multi-organ failure? Intensive Care Med 36:750–757
  45. Pyle A, Burn DJ, Gordon C, Swan C, Chinnery PF, Baudouin SV (2010) Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis. Intensive Care Med 36:956–962
  46. Ait-Oufella H, Maury E, Lehoux S, Guidet B, Offenstadt G (2010) The endothelium: physiological functions and role in microcirculatory failure during severe sepsis. Intensive Care Med 36:1286–1298
  47. Levy B, Collin S, Sennoun N, Ducrocq N, Kimmoun A, Asfar P, Perez P, Meziani F (2010) Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedside. Intensive Care Med 36:2019–2029
  48. De Backer D, Ospina-Tascon G, Salgado D, Favory R, Creteur J, Vincent JL (2010) Monitoring the microcirculation in the critically ill patient: current methods and future approaches. Intensive Care Med 36:1813–1825
  49. Boerma EC, Ince C (2010) The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med 36:2004–2018
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  51. Leal-Noval SR, Cayuela A, Arellano-Orden V, Marin-Caballos A, Padilla V, Ferrandiz-Millon C, Corcia Y, Garcia-Alfaro C, Amaya-Villar R, Murillo-Cabezas F (2010) Invasive and noninvasive assessment of cerebral oxygenation in patients with severe traumatic brain injury. Intensive Care Med 36:1309–1317
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  53. Bouzat P, Francony G, Brun J, Lavagne P, Picard J, Broux C, Declety P, Jacquot C, Albaladejo P, Payen JF (2010) Detecting traumatic internal carotid artery dissection using transcranial doppler in head-injured patients. Intensive Care Med 36:1514–1520
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  56. Seder DB, Fraser GL, Robbins T, Libby L, Riker RR (2010) The bispectral index and suppression ratio are very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest. Intensive Care Med 36:281–288
  57. Plaschke K, Fichtenkamm P, Schramm C, Hauth S, Martin E, Verch M, Karck M, Kopitz J (2010) Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Intensive Care Med 36:2081–2089
  58. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, Chalfin DB, Masica MF, Bjerke HS, Coplin WM, Crippen DW, Fuchs BD, Kelleher RM, Marik PE, Nasraway SA Jr, Murray MJ, Peruzzi WT, Lumb PD (2002) Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 30:119–141
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  60. Legriel S, Marijon H, Darmon M, Lemiale V, Bedos JP, Schlemmer B, Azoulay E (2010) Central neurological complications in critically ill patients with malignancies. Intensive Care Med 36:232–240
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  68. Fanelli V, Puntorieri V, Assenzio B, Martin EL, Elia V, Bosco M, Delsedime L, Del Sorbo L, Ferrari A, Italiano S, Ghigo A, Slutsky AS, Hirsch E, Ranieri VM (2010) Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kgamma) contributes to ventilator-induced lung injury and edema. Intensive Care Med 36:1935–1945
  69. Vlaar AP, Wolthuis EK, Hofstra JJ, Roelofs JJ, Boon L, Schultz MJ, Lutter R, Juffermans NP (2010) Mechanical ventilation aggravates transfusion-related acute lung injury induced by MHC-I class antibodies. Intensive Care Med 36:879–887
  70. Dargaville PA, Rimensberger PC, Frerichs I (2010) Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre. Intensive Care Med 36:1953–1961
  71. Rees SE, Kjaergaard S, Andreassen S, Hedenstierna G (2010) Reproduction of inert gas and oxygenation data: a comparison of the MIGET and a simple model of pulmonary gas exchange. Intensive Care Med 36:2117–2124
  72. Saddy F, Oliveira GP, Garcia CS, Nardelli LM, Rzezinski AF, Ornellas DS, Morales MM, Capelozzi VL, Pelosi P, Rocco PR (2010) Assisted ventilation modes reduce the expression of lung inflammatory and fibrogenic mediators in a model of mild acute lung injury. Intensive Care Med 36:1417–1426
  73. Henzler D, Hochhausen N, Bensberg R, Schachtrupp A, Biechele S et al (2010) Effects of preserved spontaneous breathing activity during mechanical ventilation in experimental intra-abdominal hypertension. Intensive Care Med 36:1427–1435
  74. Peltekova V, Engelberts D, Otulakowski G, Uematsu S, Post M, Kavanagh BP (2010) Hypercapnic acidosis in ventilator-induced lung injury. Intensive Care Med 36:869–878
  75. Aslami H, Heinen A, Roelofs JJ, Zuurbier CJ, Schultz MJ, Juffermans NP (2010) Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury. Intensive Care Med 36:1946–1952
  76. López-Aguilar J, Quilez ME, Marti-Sistac O, Garcia-Martin C, Fuster G, Puig F, Flores C, Villar J, Artigas A, Blanch L (2010) Early physiological and biological features in three animal models of induced acute lung injury. Intensive Care Med 36:347–355
  77. He X, Han B, Bai X, Zhang Y, Cypel M, Mura M, Keshavjee S, Liu M (2010) PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentation. Intensive Care Med 36:356–364
  78. Zhang H, Damas P, Preiser JC (2010) The long way of biomarkers: from bench to bedside. Intensive Care Med 36:565–566
  79. Saotome T, Ishikawa K, May CN, Birchall IE, Bellomo R (2010) The impact of experimental hypoperfusion on subsequent kidney function. Intensive Care Med 36:533–540
  80. Groesdonk HV, Heringlake M (2010) The kidney in acute renal failure: innocent bystander, victim or still a suspect? Intensive Care Med 36:389–391
  81. Crisafulli C, Mazzon E, Galuppo M, Paterniti I, Caminiti R, Cuzzocrea S (2010) Olprinone attenuates the development of ischemia/reperfusion injury of the gut. Intensive Care Med 36:1235–1247
  82. Cui X, Su J, Li Y, Shiloach J, Solomon S, Kaufman JB, Mani H, Fitz Y, Weng J, Altaweel L, Besch V, Eichacker PQ (2010) Bacillus anthracis cell wall produces injurious inflammation but paradoxically decreases the lethality of anthrax lethal toxin in a rat model. Intensive Care Med 36:148–156
  83. Joynt C, Bigam DL, Charrois G, Jewell LD, Korbutt G, Cheung PY (2010) Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen. Intensive Care Med 36:1058–1066
  84. Villar J, Cabrera N, Casula M, Flores C, Valladares F, Muros M, Blanch L, Slutsky AS, Kacmarek RM (2010) Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model. Intensive Care Med 36:1049–1057
  85. Schick MA, Isbary TJ, Schlegel N, Brugger J, Waschke J, Muellenbach R, Roewer N, Wunder C (2010) The impact of crystalloid and colloid infusion on the kidney in rodent sepsis. Intensive Care Med 36:541–548
  86. Polito A, de la Lorin Grandmaison G, Mansart A, Louiset E, Lefebvre H, Sharshar T, Annane D (2010) Human and experimental septic shock are characterized by depletion of lipid droplets in the adrenals. Intensive Care Med 36:1852–1858
  87. Secor D, Li F, Ellis CG, Sharpe MD, Gross PL, Wilson JX, Tyml K (2010) Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med 36:1928–1934
  88. Tsao CM, Chen SJ, Shih MC, Lue WM, Tsou MY, Chen A, Liaw WJ, Wu CC (2010) Effects of terbutaline on circulatory failure and organ dysfunction induced by peritonitis in rats. Intensive Care Med 36:1571–1578

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