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Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teachingOpen access

Massimo Antonelli| Elie Azoulay| Marc Bonten| Jean Chastre| Giuseppe Citerio| Giorgio Conti| Daniel De Backer| François Lemaire| Herwig Gerlach| Goran Hedenstierna| Michael Joannidis| Duncan Macrae| Jordi Mancebo| Salvatore M. Maggiore| Alexandre Mebazaa| Jean-Charles Preiser| Jerôme Pugin| Jan Wernerman| Haibo Zhang
Year in Review 2009
Volume 36, Issue 3 / March , 2010

Pages 412 - 427

No abstract available.


  1. Spronk PE, Riekerk B, Hofhuis J, Rommes JH (2009) Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med 35:1276–1280
  2. Pandharipande PP, Morandi A, Adams JR, Girard TD, Thompson JL, Shintani AK, Ely EW (2009) Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med 35:1886–1892
  3. Myhren H, Toien K, Ekeberg O, Karlsson S, Sandvik L, Stokland O (2009) Patients’ memory and psychological distress after ICU stay compared with expectations of the relatives. Intensive Care Med 35:2078–2086
  4. Figueroa-Ramos MI, Arroyo-Novoa CM, Lee KA, Padilla G, Puntillo KA (2009) Sleep and delirium in ICU patients: a review of mechanisms and manifestations. Intensive Care Med 35:781–795
  5. Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM (2009) Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 35:796–809
  6. Sena MJ, Rivers RM, Muizelaar JP, Battistella FD, Utter GH (2009) Transfusion practices for acute traumatic brain injury: a survey of physicians at US trauma centers. Intensive Care Med 35:480–488
  7. Lavinio A, Rasulo FA, De Peri E, Czosnyka M, Latronico N (2009) The relationship between the intracranial pressure-volume index and cerebral autoregulation. Intensive Care Med 35:546–549
  8. Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, Grimaud D, Leverve X (2009) Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med 35:471–479
  9. Sahuquillo J, Perez-Barcena J, Biestro A, Zavala E, Merino MA, Vilalta A, Poca MA, Garnacho A, Adalia R, Homar J, LL-P JA (2009) Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool). Intensive Care Med 35:890–898
  10. Hough CL, Steinberg KP, Taylor Thompson B, Rubenfeld GD, Hudson LD (2009) Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med 35:63–68
  11. Herridge MS (2009) Building consensus on ICU-acquired weakness. Intensive Care Med 35:1–3
  12. Kesler SM, Sprenkle MD, David WS, Leatherman JW (2009) Severe weakness complicating status asthmaticus despite minimal duration of neuromuscular paralysis. Intensive Care Med 35:157–160
  13. Pease S, Bouadma L, Kermarrec N, Schortgen F, Regnier B, Wolff M (2009) Early organ dysfunction course, cooling time and outcome in classic heatstroke. Intensive Care Med 35:1454–1458
  14. Osman D, Monnet X, Castelain V, Anguel N, Warszawski J, Teboul JL, Richard C (2009) Incidence and prognostic value of right ventricular failure in acute respiratory distress syndrome. Intensive Care Med 35:69–76
  15. Mekontso Dessap A, Charron C, Devaquet J, Aboab J, Jardin F, Brochard L, Vieillard-Baron A (2009) Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med 35:1850–1858
  16. Jochberger S, Velik-Salchner C, Mayr VD, Luckner G, Wenzel V, Falkensammer G, Ulmer H, Morgenthaler N, Hasibeder W, Dunser MW (2009) The vasopressin and copeptin response in patients with vasodilatory shock after cardiac surgery: a prospective, controlled study. Intensive Care Med 35:489–497
  17. Monge Garcia MI, Gil Cano A, Diaz Monrove JC (2009) Arterial pressure changes during the Valsalva maneuver to predict fluid responsiveness in spontaneously breathing patients. Intensive Care Med 35:77–84
  18. Carr BG, Goyal M, Band RA, Gaieski DF, Abella BS, Merchant RM, Branas CC, Becker LB, Neumar RW (2009) A national analysis of the relationship between hospital factors and post-cardiac arrest mortality. Intensive Care Med 35:505–511
  19. Marchick MR, Kline JA, Jones AE (2009) The significance of non-sustained hypotension in emergency department patients with sepsis. Intensive Care Med 35:1261–1264
  20. Dunser MW, Takala J, Ulmer H, Mayr VD, Luckner G, Jochberger S, Daudel F, Lepper P, Hasibeder WR, Jakob SM (2009) Arterial blood pressure during early sepsis and outcome. Intensive Care Med 35:1225–1233
  21. De Backer D, Heenen S, Piagnerelli M, Koch M, Vincent JL (2005) Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med 31:517–523
  22. Vallee F, Richard JC, Mari A, Gallas T, Arsac E, Verlaan PS, Chousterman B, Samii K, Genestal M, Fourcade O (2009) Pulse pressure variations adjusted by alveolar driving pressure to assess fluid responsiveness. Intensive Care Med 35:1004–1010
  23. Lefrant JY, De Backer D (2009) Can we use pulse pressure variations to predict fluid responsiveness in patients with ARDS? Intensive Care Med 35:966–968
  24. Monnet X, Teboul JL (2008) Passive leg raising. Intensive Care Med 34:659–663
  25. Jabot J, Teboul JL, Richard C, Monnet X (2009) Passive leg raising for predicting fluid responsiveness: importance of the postural change. Intensive Care Med 35:85–90
  26. Squara P, Cecconi M, Rhodes A, Singer M, Chiche JD (2009) Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med 35:1801–1808
  27. Cecconi M, Dawson D, Grounds RM, Rhodes A (2009) Lithium dilution cardiac output measurement in the critically ill patient: determination of precision of the technique. Intensive Care Med 35:498–504
  28. D’Ancona G, Parrinello M, Santise G, Biondo D, Pirone F, Sciacca S, Turrisi M, Arcadipane A, Pilato M (2009) Intraoperative validation of a new system for invasive continuous cardiac output measurement. Intensive Care Med 35:943–947
  29. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34:17–60
  30. Mesquida J, Masip J, Gili G, Artigas A, Baigorri F (2009) Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients. Intensive Care Med 35:1106–1109
  31. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM (2008) Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 34:2210–2217
  32. den Uil CA, Caliskan K, Lagrand WK, van der Ent M, Jewbali LS, van Kuijk JP, Spronk PE, Simoons ML (2009) Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure. Intensive Care Med 35:1893–1899
  33. Dubin A, Pozo MO, Ferrara G, Murias G, Martins E, Canullan C, Canales HS, Kanoore Edul VS, Estenssoro E, Ince C (2009) Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med 35:556–564
  34. Jhanji S, Lee C, Watson D, Hinds C, Pearse RM (2009) Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications. Intensive Care Med 35:671–677
  35. Vieillard-Baron A, Charron C, Chergui K, Peyrouset O, Jardin F (2006) Bedside echocardiographic evaluation of hemodynamics in sepsis: is a qualitative evaluation sufficient? Intensive Care Med 32:1547–1552
  36. Arnold RC, Parrillo JE, Phillip Dellinger R, Chansky ME, Shapiro NI, Lundy DJ, Trzeciak S, Hollenberg SM (2009) Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med 35:1761–1766
  37. Hartog C, Reinhart K (2009) CONTRA: hydroxyethyl starch solutions are unsafe in critically ill patients. Intensive Care Med 35:1337–1342
  38. Boldt J (2009) PRO: hydroxyethylstarch can be safely used in the intensive care patient–the renal debate. Intensive Care Med 35:1331–1336
  39. Schabinski F, Oishi J, Tuche F, Luy A, Sakr Y, Bredle D, Hartog C, Reinhart K (2009) Effects of a predominantly hydroxyethyl starch (HES)-based and a predominantly non HES-based fluid therapy on renal function in surgical ICU patients. Intensive Care Med 35:1539–1547
  40. Boldt J, Suttner S, Brosch C, Lehmann A, Rohm K, Mengistu A (2009) The influence of a balanced volume replacement concept on inflammation, endothelial activation, and kidney integrity in elderly cardiac surgery patients. Intensive Care Med 35:462–470
  41. Morisaki H, Yajima S, Watanabe Y, Suzuki T, Yamamoto M, Katori N, Hashiguchi S, Takeda J (2009) Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. Intensive Care Med 35:129–135
  42. Gnaegi A, Feihl F, Boulat O, Waeber B, Liaudet L (2009) Moderate hypercapnia exerts beneficial effects on splanchnic energy metabolism during endotoxemia. Intensive Care Med 35:1297–1304
  43. Di Paola R, Menegazzi M, Mazzon E, Genovese T, Crisafulli C, Dal Bosco M, Zou Z, Suzuki H, Cuzzocrea S (2009) Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model. Intensive Care Med 35:687–697
  44. Zanotti-Cavazzoni SL, Guglielmi M, Parrillo JE, Walker T, Dellinger RP, Hollenberg SM (2009) Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis. Intensive Care Med 35:748–754
  45. Baumgart K, Simkova V, Wagner F, Weber S, Georgieff M, Radermacher P, Albuszies G, Barth E (2009) Effect of SOD-1 over-expression on myocardial function during resuscitated murine septic shock. Intensive Care Med 35:344–349
  46. Hagiwara S, Iwasaka H, Matsumoto S, Noguchi T (2008) High dose antithrombin III inhibits HMGB1 and improves endotoxin-induced acute lung injury in rats. Intensive Care Med 34:361–367
  47. Hagiwara S, Iwasaka H, Hidaka S, Hasegawa A, Koga H, Noguchi T (2009) Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats. Intensive Care Med 35:1471–1478
  48. Hagiwara S, Iwasaka H, Hasegawa A, Asai N, Noguchi T (2008) High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis. Intensive Care Med 34:1812–1819
  49. Pugin J (2008) Dear SIRS, the concept of “alarmins” makes a lot of sense!. Intensive Care Med 34:218–221
  50. Rehberg S, Ertmer C, Kohler G, Spiegel HU, Morelli A, Lange M, Moll K, Schlack K, Van Aken H, Su F, Vincent JL, Westphal M (2009) Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shock. Intensive Care Med 35:1286–1296
  51. Wolff S, Klatt S, Wolff JC, Wilhelm J, Fink L, Kaps M, Rosengarten B (2009) Endotoxin-induced gene expression differences in the brain and effects of iNOS inhibition and norepinephrine. Intensive Care Med 35:730–739
  52. Sykora R, Chvojka J, Krouzecky A, Radej J, Karvunidis T, Varnerova V, Novak I, Matejovic M (2009) High versus standard-volume haemofiltration in hyperdynamic porcine peritonitis: effects beyond haemodynamics? Intensive Care Med 35:371–380
  53. Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, Muhl H, Boost KA, Hofstetter C (2009) Effects of intravenous and inhaled levosimendan in severe rodent sepsis. Intensive Care Med 35:1412–1419
  54. Leendertse M, Willems RJ, Giebelen IA, Florquin S, van den Pangaart PS, Bonten MJ, van der Poll T (2009) Cecal ligation and puncture induced sepsis impairs host defense against Enterococcus faecium peritonitis. Intensive Care Med 35:924–932
  55. Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohe J, Lepape A, Ayala A, Monneret G (2009) Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 35:678–686
  56. Ferrari F, Liu ZH, Lu Q, Becquemin MH, Louchahi K, Aymard G, Marquette CH, Rouby JJ (2008) Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers. Intensive Care Med 34:1718–1723
  57. Ferrari F, Lu Q, Girardi C, Petitjean O, Marquette CH, Wallet F, Rouby JJ (2009) Nebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosa. Intensive Care Med 35:1792–1800
  58. Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS (2009) A comparison of methods to identify open-lung PEEP. Intensive Care Med 35:740–747
  59. Dellaca RL, Andersson Olerud M, Zannin E, Kostic P, Pompilio PP, Hedenstierna G, Pedotti A, Frykholm P (2009) Lung recruitment assessed by total respiratory system input reactance. Intensive Care Med 35:2164–2172
  60. Steimback PW, Oliveira GP, Rzezinski AF, Silva PL, Garcia CS, Rangel G, Morales MM, Lapa ESJR, Capelozzi VL, Pelosi P, Rocco PR (2009) Effects of frequency and inspiratory plateau pressure during recruitment manoeuvres on lung and distal organs in acute lung injury. Intensive Care Med 35:1120–1128
  61. Pellicano A, Tingay DG, Mills JF, Fasulakis S, Morley CJ, Dargaville PA (2009) Comparison of four methods of lung volume recruitment during high frequency oscillatory ventilation. Intensive Care Med 35:1990–1998
  62. Martinez-Caro L, Lorente JA, Marin-Corral J, Sanchez-Rodriguez C, Sanchez-Ferrer A, Nin N, Ferruelo A, de Paula M, Fernandez-Segoviano P, Barreiro E, Esteban A (2009) Role of free radicals in vascular dysfunction induced by high tidal volume ventilation. Intensive Care Med 35:1110–1119
  63. Bueltmann M, Kong X, Mertens M, Yin N, Yin J, Liu Z, Koster A, Kuppe H, Kuebler WM (2009) Inhaled milrinone attenuates experimental acute lung injury. Intensive Care Med 35:171–178
  64. Dyson A, Stidwill R, Taylor V, Singer M (2009) The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage. Intensive Care Med 35:1783–1791
  65. Douzinas EE (2009) Progressive hemorrhage: administer oxygen or early resuscitation? Intensive Care Med 35:1664–1666
  66. Hare GM, Liu E, Baker AJ, Mazer CD (2009) Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats. Intensive Care Med 35:1925–1933
  67. Liu KX, Li YS, Huang WQ, Chen SQ, Wang ZX, Liu JX, Xia Z (2009) Immediate postconditioning during reperfusion attenuates intestinal injury. Intensive Care Med 35:933–942
  68. Krouzecky A, Chvojka J, Sykora R, Radej J, Karvunidis T, Novak I, Ruzicka J, Petrankova Z, Benes J, Bolek L, Matejovic M (2009) Regional cooling of the extracorporeal blood circuit: a novel anticoagulation approach for renal replacement therapy? Intensive Care Med 35:364–370
  69. Bagshaw SM, Davenport A (2009) Cooling and reduced risk of clotting within the extracorporeal continuous renal replacement circuit. Intensive Care Med 35:195–197
  70. Mouly S, Meune C, Bergmann JF (2009) Mini-series: I. Basic science. Uncertainty and inaccuracy of predicting CYP-mediated in vivo drug interactions in the ICU from in vitro models: focus on CYP3A4. Intensive Care Med 35:417–429
  71. Spriet I, Meersseman W, de Hoon J, von Winckelmann S, Wilmer A, Willems L (2009) Mini-series: II. Clinical aspects. Clinically relevant CYP450-mediated drug interactions in the ICU. Intensive Care Med 35:603–612
  72. Schwake L, Wollenschlager I, Stremmel W, Encke J (2009) Adverse drug reactions and deliberate self-poisoning as cause of admission to the intensive care unit: a 1-year prospective observational cohort study. Intensive Care Med 35:266–274
  73. Brown SG, Caruso N, Borland ML, McCoubrie DL, Celenza A, Isbister GK (2009) Clotting factor replacement and recovery from snake venom-induced consumptive coagulopathy. Intensive Care Med 35:1532–1538
  74. Struck MF, Hilbert P, Mockenhaupt M, Reichelt B, Steen M (2009) Severe cutaneous adverse reactions: emergency approach to non-burn epidermolytic syndromes. Intensive Care Med (in press)
  75. Migliari M, Bellani G, Rona R, Isgro S, Vergnano B, Mauri T, Patroniti N, Pesenti A, Foti G (2009) Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients. Intensive Care Med 35:1240–1246
  76. Kirwan CJ, Lee T, Holt DW, Grounds RM, MacPhee IA, Philips BJ (2009) Using midazolam to monitor changes in hepatic drug metabolism in critically ill patients. Intensive Care Med 35:1271–1275
  77. Ruokonen E, Parviainen I, Jakob SM, Nunes S, Kaukonen M, Shepherd ST, Sarapohja T, Bratty JR, Takala J (2009) Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive Care Med 35:282–290
  78. Chanques G, Payen JF, Mercier G, de Lattre S, Viel E, Jung B, Cisse M, Lefrant JY, Jaber S (2010) Assessing pain in non-intubated critically ill patients unable to self report: an adaptation of the Behavioral Pain Scale. Intensive Care Med (in press)
  79. Tardy-Poncet B, Wolf M, Lasne D, Bauters A, Ffrench P, Elalamy I, Tardy B (2009) Danaparoid cross-reactivity with heparin-induced thrombocytopenia antibodies: report of 12 cases. Intensive Care Med 35:1449–1453
  80. Francis RC, Schefold JC, Bercker S, Temmesfeld-Wollbruck B, Weichert W, Spies CD, Weber-Carstens S (2009) Acute respiratory failure after aspiration of activated charcoal with recurrent deposition and release from an intrapulmonary cavern. Intensive Care Med 35:360–363
  81. Rego Lins Fumis R, Deheinzelin D (2009) Family members of critically ill cancer patients: assessing the symptoms of anxiety and depression. Intensive Care Med 35:899–902
  82. Stricker KH, Kimberger O, Schmidlin K, Zwahlen M, Mohr U, Rothen HU (2009) Family satisfaction in the intensive care unit: what makes the difference? Intensive Care Med (in press)
  83. Tremey B, Tazarourte K, Ract C, Gabteni M, Lavagna L, Depret-Vassal J, Segalin V, Saintonge S, Vigue B (2009) Teaching improves adherence to clinical guidelines in the treatment of oral anticoagulation-related severe bleeding in the emergency department. Intensive Care Med 35:1444–1448
  84. Chalumeau-Lemoine L, Baudel JL, Das V, Arrive L, Noblinski B, Guidet B, Offenstadt G, Maury E (2009) Results of short-term training of naive physicians in focused general ultrasonography in an intensive-care unit. Intensive Care Med 35:1767–1771
  85. The CoBaTrICE Collaboration (2009) The educational environment for training in intensive care medicine: structures, processes, outcomes and challenges in the European region. Intensive Care Med 35:1575–1583

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