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Year in review in Intensive Care Medicine 2009: I. Pneumonia and infections, sepsis, outcome, acute renal failure and acid base, nutrition and glycaemic controlOpen access

Massimo Antonelli| Elie Azoulay| Marc Bonten| Jean Chastre| Giuseppe Citerio| Giorgio Conti| Daniel De Backer| François Lemaire| Herwig Gerlach| Goran Hedenstierna| Michael Joannidis| Duncan Macrae| Jordi Mancebo| Salvatore M. Maggiore| Alexandre Mebazaa| Jean-Charles Preiser| Jerôme Pugin| Jan Wernerman| Haibo Zhang
Year in Review 2009
Volume 36, Issue 2 / February , 2010

Pages 196 - 209

No abstract available.


  1. Jung B, Sebbane M, Chanques G, Courouble P, Verzilli D, Perrigault PF, Jean-Pierre H, Eledjam JJ, Jaber S (2009) Previous endotracheal aspirate allows guiding the initial treatment of ventilator-associated pneumonia. Intensive Care Med 35:101–107
  2. Patman S, Jenkins S, Stiller K (2009) Physiotherapy does not prevent, or hasten recovery from, ventilator-associated pneumonia in patients with acquired brain injury. Intensive Care Med 35:258–265
  3. Martinez JA, Delgado E, Marti S, Marco F, Vila J, Mensa J, Torres A, Codina C, Trilla A, Soriano A, Alquezar A, Castro P, Nicolas JM (2009) Influence of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance in critically ill medical patients. Intensive Care Med 35:439–447
  4. Rodriguez A, Lisboa T, Blot S, Martin-Loeches I, Sole-Violan J, De Mendoza D, Rello J (2009) Mortality in ICU patients with bacterial community-acquired pneumonia: when antibiotics are not enough. Intensive Care Med 35:430–438
  5. Knight DJ, Gardiner D, Banks A, Snape SE, Weston VC, Bengmark S, Girling KJ (2009) Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial. Intensive Care Med 35:854–861
  6. Baldesi O, Michel F, Guervilly C, Embriaco N, Granfond A, La Scola B, Portugal H, Papazian L (2009) Bacterial ventilator-associated pneumonia: bronchoalveolar lavage results are not influenced by dilution. Intensive Care Med 35:1210–1215
  7. Oudhuis GJ, Beuving J, Bergmans D, Stobberingh EE, ten Velde G, Linssen CF, Verbon A (2009) Soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia. Intensive Care Med 35:1265–1270
  8. Jiyong J, Tiancha H, Wei C, Huahao S (2009) Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 35:587–595
  9. Hawe CS, Ellis KS, Cairns CJ, Longmate A (2009) Reduction of ventilator-associated pneumonia: active versus passive guideline implementation. Intensive Care Med 35:1180–1186
  10. de Smet AM, Hopmans TE, Minderhoud AL, Blok HE, Gossink-Franssen A, Bernards AT, Bonten MJ (2009) Decontamination of the digestive tract and oropharynx: hospital acquired infections after discharge from the intensive care unit. Intensive Care Med 35:1609–1613
  11. Hortal J, Giannella M, Perez MJ, Barrio JM, Desco M, Bouza E, Munoz P (2009) Incidence and risk factors for ventilator-associated pneumonia after major heart surgery. Intensive Care Med 35:1518–1525
  12. Torres A, Ewig S, Lode H, Carlet J (2009) Defining, treating and preventing hospital acquired pneumonia: European perspective. Intensive Care Med 35:9–29
  13. Torres A, Ewig S (2009) Reply to van Saene et al. Intensive Care Med 35:1817
  14. Zandstra DF, Petros AJ, van Saene HK (2009) The final gasp from the European experts. Intensive Care Med 35:1816; author reply 1817
  15. Barbier F, Coquet I, Legriel S, Pavie J, Darmon M, Mayaux J, Molina JM, Schlemmer B, Azoulay E (2009) Etiologies and outcome of acute respiratory failure in HIV-infected patients. Intensive Care Med 35:1678–1686
  16. Azoulay E, Cohen Y, Zahar J-R, Garrouste-Orgeas M, Adrie C, Moine P, de Lassence A, Timsit J-F (2004) Practices in non-neutropenic ICU patients with Candida-positive airway specimens. Intensive Care Med 30:1384–1389
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  17. Meersseman W, Lagrou K, Spriet I, Maertens J, Verbeken E, Peetermans WE, Van Wijngaerden E (2009) Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study. Intensive Care Med 35:1526–1531
  18. Guery BP, Arendrup MC, Auzinger G, Azoulay E, Borges Sa M, Johnson EM, Muller E, Putensen C, Rotstein C, Sganga G, Venditti M, Zaragoza Crespo R, Kullberg BJ (2009) Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis. Intensive Care Med 35:55–62
  19. Guery BP, Arendrup MC, Auzinger G, Azoulay E, Borges Sa M, Johnson EM, Muller E, Putensen C, Rotstein C, Sganga G, Venditti M, Zaragoza Crespo R, Kullberg BJ (2009) Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment. Intensive Care Med 35:206–214
  20. Hanberger H, Arman D, Gill H, Jindrak V, Kalenic S, Kurcz A, Licker M, Naaber P, Scicluna EA, Vanis V, Walther SM (2009) Surveillance of microbial resistance in European intensive care units: a first report from the Care-ICU programme for improved infection control. Intensive Care Med 35:91–100
  21. Meyer E, Lapatschek M, Bechtold A, Schwarzkopf G, Gastmeier P, Schwab F (2009) Impact of restriction of third generation cephalosporins on the burden of third generation cephalosporin resistant K. pneumoniae and E. coli in an ICU. Intensive Care Med 35:862–870
  22. Caricato A, Montini L, Bello G, Michetti V, Maviglia R, Bocci MG, Mercurio G, Maggiore SM, Antonelli M (2009) Risk factors and outcome of Acinetobacter baumanii infection in severe trauma patients. Intensive Care Med 35:1964–1969
  23. Playford EG, Lipman J, Kabir M, McBryde ES, Nimmo GR, Lau A, Sorrell TC (2009) Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients. Intensive Care Med 35:2141–2145
  24. Charles PE, Castro C, Ruiz-Santana S, Leon C, Saavedra P, Martin E (2009) Serum procalcitonin levels in critically ill patients colonized with Candida spp: new clues for the early recognition of invasive candidiasis? Intensive Care Med 35:2146–2150
  25. Perez-Parra A, Munoz P, Guinea J, Martin-Rabadan P, Guembe M, Bouza E (2009) Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals? Intensive Care Med 35:707–712
  26. Senn L, Eggimann P, Ksontini R, Pascual A, Demartines N, Bille J, Calandra T, Marchetti O (2009) Caspofungin for prevention of intraabdominal candidiasis in high-risk surgical patients. Intensive Care Med 35:903–908
  27. Michalia M, Kompoti M, Koutsikou A, Paridou A, Giannopoulou P, Trikka-Graphakos E, Clouva-Molyvdas P (2009) Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections. Intensive Care Med 35:448–454
  28. Karvellas CJ, Pink F, McPhail M, Cross T, Auzinger G, Bernal W, Sizer E, Kutsogiannis DJ, Eltringham I, Wendon JA (2009) Predictors of bacteraemia and mortality in patients with acute liver failure. Intensive Care Med 35:1390–1396
  29. Saayman AG, Findlay GP, Barnes RA, Wise MP (2009) Bacteraemia following single-stage percutaneous dilatational tracheostomy. Intensive Care Med 35:1970–1973
  30. Boyer A, Vargas F, Coste F, Saubusse E, Castaing Y, Gbikpi-Benissan G, Hilbert G, Gruson D (2009) Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management. Intensive Care Med 35:847–853
  31. Souweine B, Lautrette A, Aumeran C, Benedit M, Constantin JM, Bonnard M, Guelon D, Amat G, Aublet B, Bonnet R, Traore O (2009) Comparison of acceptability, skin tolerance, and compliance between handwashing and alcohol-based handrub in ICUs: results of a multicentric study. Intensive Care Med 35:1216–1224
  32. Silvestre J, Povoa P, Coelho L, Almeida E, Moreira P, Fernandes A, Mealha R, Sabino H (2009) Is C-reactive protein a good prognostic marker in septic patients? Intensive Care Med 35:909–913
  33. Manzanares W, Biestro A, Galusso F, Torre MH, Manay N, Pittini G, Facchin G, Hardy G (2009) Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill? Intensive Care Med 35:882–889
  34. Guignant C, Voirin N, Venet F, Poitevin F, Malcus C, Bohe J, Lepape A, Monneret G (2009) Assessment of pro-vasopressin and pro-adrenomedullin as predictors of 28-day mortality in septic shock patients. Intensive Care Med 35:1859–1867
  35. Berg RM, Strauss GI, Tofteng F, Qvist T, Edvinsson L, Fahrenkrug J, Qvist J, Fonsmark L, Skinhoj P, Moller K (2009) Circulating levels of vasoactive peptides in patients with acute bacterial meningitis. Intensive Care Med 35:1604–1608
  36. van der Heijden M, Pickkers P, van Nieuw Amerongen GP, van Hinsbergh VW, Bouw MP, van der Hoeven JG, Groeneveld AB (2009) Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality. Intensive Care Med 35:1567–1574
  37. Barlage S, Gnewuch C, Liebisch G, Wolf Z, Audebert FX, Gluck T, Frohlich D, Kramer BK, Rothe G, Schmitz G (2009) Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation. Intensive Care Med 35:1877–1885
  38. Su L, Zhai R, Sheu CC, Gallagher DC, Gong MN, Tejera P, Thompson BT, Christiani DC (2009) Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS. Intensive Care Med 35:1024–1030
  39. Takaki S, Takeyama N, Kajita Y, Yabuki T, Noguchi H, Miki Y, Inoue Y, Nakagawa T (2009) Beneficial effects of the heme oxygenase-1/carbon monoxide system in patients with severe sepsis/septic shock. Intensive Care Med. doi:10.1007/s00134-009-1575-4
  40. Fuhrmann V, Kneidinger N, Herkner H, Heinz G, Nikfardjam M, Bojic A, Schellongowski P, Angermayr B, Kitzberger R, Warszawska J, Holzinger U, Schenk P, Madl C (2009) Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients. Intensive Care Med 35:1397–1405
  41. Thomson SJ, Cowan ML, Johnston I, Musa S, Grounds M, Rahman TM (2009) ‘Liver function tests’ on the intensive care unit: a prospective, observational study. Intensive Care Med 35:1406–1411
  42. Kruger PS, Freir NM, Venkatesh B, Robertson TA, Roberts MS, Jones M (2009) A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med 35:717–721
  43. Novack V, Eisinger M, Frenkel A, Terblanche M, Adhikari NK, Douvdevani A, Amichay D, Almog Y (2009) The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med 35:1255–1260
  44. Vieillard-Baron A, Caille V, Charron C, Belliard G, Aegerter P, Page B, Jardin F (2009) Reversal of refractory septic shock with drotrecogin alpha (activated). Intensive Care Med 35:1204–1209
  45. Dhainaut JF, Antonelli M, Wright P, Desachy A, Reignier J, Lavoue S, Charpentier J, Belger M, Cobas-Meyer M, Maier C, Mignini MA, Janes J (2009) Extended drotrecogin alpha (activated) treatment in patients with prolonged septic shock. Intensive Care Med 35:1187–1195
  46. Levy M, Levi M, Williams MD, Antonelli M, Wang D, Mignini MA (2009) Comprehensive safety analysis of concomitant drotrecogin alpha (activated) and prophylactic heparin use in patients with severe sepsis. Intensive Care Med 35:1196–1203
  47. Crivellari M, Della Valle P, Landoni G, Pappalardo F, Gerli C, Bignami E, Marino G, Zangrillo A, D’Angelo A (2009) Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery. Intensive Care Med 35:1959–1963
  48. Prat G, Lefevre M, Nowak E, Tonnelier JM, Renault A, L’Her E, Boles JM (2009) Impact of clinical guidelines to improve appropriateness of laboratory tests and chest radiographs. Intensive Care Med 35:1047–1053
  49. Briegel J, Sprung CL, Annane D, Singer M, Keh D, Moreno R, Mohnle P, Weiss Y, Avidan A, Brunkhorst FM, Fiedler F, Vogeser M (2009) Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock. Intensive Care Med 35:2151–2156
  50. Cuthbertson BH, Sprung CL, Annane D, Chevret S, Garfield M, Goodman S, Laterre PF, Vincent JL, Freivogel K, Reinhart K, Singer M, Payen D, Weiss YG (2009) The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 35:1868–1876
  51. Riutta A, Ylitalo P, Kaukinen S (2009) Diurnal variation of melatonin and cortisol is maintained in non-septic intensive care patients. Intensive Care Med 35:1720–1727
  52. Hogue CW Jr, Stearns JD, Colantuoni E, Robinson KA, Stierer T, Mitter N, Pronovost PJ, Needham DM (2009) The impact of obesity on outcomes after critical illness: a meta-analysis. Intensive Care Med 35:1152–1170
  53. Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M (2009) Modeling the effect of time-dependent exposure on intensive care unit mortality. Intensive Care Med 35:826–832
  54. Buschmann CT, Tsokos M (2009) Frequent and rare complications of resuscitation attempts. Intensive Care Med 35:397–404
  55. Wright SE, Lochan R, Imrie K, Baker C, Nesbitt ID, Kilner AJ, Charnley RM (2009) Quality of life and functional outcome at 3, 6 and 12 months after acute necrotising pancreatitis. Intensive Care Med 35:1974–1978
  56. Iribarren-Diarasarri S, Aizpuru-Barandiaran F, Munoz-Martinez T, Loma-Osorio A, Hernandez-Lopez M, Ruiz-Zorrilla JM, Castillo-Arenal C, Dudagoitia-Otaolea JL, Martinez-Alutiz S, Vinuesa-Lozano C (2009) Health-related quality of life as a prognostic factor of survival in critically ill patients. Intensive Care Med 35:833–839
  57. Moreno RP, Metnitz PG, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall J-R (2005) SAPS 3? From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Med 31:1345–1355
  58. Poole D, Rossi C, Anghileri A, Giardino M, Latronico N, Radrizzani D, Langer M, Bertolini G (2009) External validation of the Simplified Acute Physiology Score (SAPS) 3 in a cohort of 28,357 patients from 147 Italian intensive care units. Intensive Care Med 35:1916–1924
  59. Ledoux D, Canivet JL, Preiser JC, Lefrancq J, Damas P (2008) SAPS 3 admission score: an external validation in a general intensive care population. Intensive Care Med 34:1873–1877
  60. Metnitz B, Schaden E, Moreno R, Le Gall JR, Bauer P, Metnitz PG (2009) Austrian validation and customization of the SAPS 3 admission score. Intensive Care Med 35:616–622
  61. Azoulay E, Metnitz B, Sprung CL, Timsit JF, Lemaire F, Bauer P, Schlemmer B, Moreno R, Metnitz P (2009) End-of-life practices in 282 intensive care units: data from the SAPS 3 database. Intensive Care Med 35:623–630
  62. Peigne V, Rusinova K, Karlin L, Darmon M, Fermand JP, Schlemmer B, Azoulay E (2009) Continued survival gains in recent years among critically ill myeloma patients. Intensive Care Med 35:512–518
  63. Herbland A, El Zein I, Valentino R, Cassinotto C, Meunier C, Rieux D, Mehdaoui H (2009) Star fruit poisoning is potentially life-threatening in patients with moderate chronic renal failure. Intensive Care Med 35:1459–1463
  64. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the Acute Dialysis Quality Initiative (ADQI) group. Crit Care 8:R204–R212
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  66. Joannidis M, Metnitz B, Bauer P, Schusterschitz N, Moreno R, Druml W, Metnitz PG (2009) Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med 35:1692–1702
  67. Joannidis M, Metnitz PG (2005) Epidemiology and natural history of acute renal failure in the ICU. Crit Care Clin 21:239–249
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  68. Bagshaw SM, Lapinsky S, Dial S, Arabi Y, Dodek P, Wood G, Ellis P, Guzman J, Marshall J, Parrillo JE, Skrobik Y, Kumar A (2009) Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med 35:871–881
  69. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Cheang M (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34:1589–1596
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  70. Cartin-Ceba R, Haugen EN, Iscimen R, Trillo-Alvarez C, Juncos L, Gajic O (2009) Evaluation of “loss” and “end stage renal disease” after acute kidney injury defined by the risk, injury, failure, loss and ESRD classification in critically ill patients. Intensive Care Med 35:2087–2095
  71. Delannoy B, Floccard B, Thiolliere F, Kaaki M, Badet M, Rosselli S, Ber CE, Saez A, Flandreau G, Guerin C (2009) Six-month outcome in acute kidney injury requiring renal replacement therapy in the ICU: a multicentre prospective study. Intensive Care Med 35:1907–1915
  72. Redfors B, Sward K, Sellgren J, Ricksten SE (2009) Effects of mannitol alone and mannitol plus furosemide on renal oxygen consumption, blood flow and glomerular filtration after cardiac surgery. Intensive Care Med 35:115–122
  73. Umgelter A, Reindl W, Franzen M, Lenhardt C, Huber W, Schmid RM (2009) Renal resistive index and renal function before and after paracentesis in patients with hepatorenal syndrome and tense ascites. Intensive Care Med 35:152–156
  74. Darmon M, Schortgen F, Leon R, Moutereau S, Mayaux J, Di Marco F, Devaquet J, Brun-Buisson C, Brochard L (2009) Impact of mild hypoxemia on renal function and renal resistive index during mechanical ventilation. Intensive Care Med 35:1031–1038
  75. Doberer D, Funk GC, Kirchner K, Schneeweiss B (2009) A critique of Stewart’s approach: the chemical mechanism of dilutional acidosis. Intensive Care Med 35:2173–2180
  76. Gattinoni L, Carlesso E, Maiocchi G, Polli F, Cadringher P (2009) Dilutional acidosis: where do the protons come from? Intensive Care Med 35:2033–2043
  77. Davenport A (2009) Dilutional acidosis or uncovered cellular metabolism? Intensive Care Med 35:2009–2011
  78. Gatz R (2009) The Stewart approach to acid-base analysis: not disqualified yet. Intensive Care Med 35:2181–2182
  79. Ring T (2009) Mixing bicarbonates: dilution acidosis from first principles. Intensive Care Med 35:2183–2184
  80. Zanella A, Patroniti N, Isgro S, Albertini M, Costanzi M, Pirrone F, Scaravilli V, Vergnano B, Pesenti A (2009) Blood acidification enhances carbon dioxide removal of membrane lung: an experimental study. Intensive Care Med 35:1484–1487
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  82. Boniatti MM, Cardoso PR, Castilho RK, Vieira SR (2009) Acid-base disorders evaluation in critically ill patients: we can improve our diagnostic ability. Intensive Care Med 35:1377–1382
  83. Funk GC, Doberer D, Sterz F, Richling N, Kneidinger N, Lindner G, Schneeweiss B, Eisenburger P (2009) The strong ion gap and outcome after cardiac arrest in patients treated with therapeutic hypothermia: a retrospective study. Intensive Care Med 35:232–239
  84. Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, Heyland DK (2009) The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 35:1728–1737
  85. Rauch S, Krueger K, Turan A, Roewer N, Sessler DI (2009) Determining small intestinal transit time and pathomorphology in critically ill patients using video capsule technology. Intensive Care Med 35:1054–1059
  86. Holzinger U, Kitzberger R, Bojic A, Wewalka M, Miehsler W, Staudinger T, Madl C (2009) Comparison of a new unguided self-advancing jejunal tube with the endoscopic guided technique: a prospective, randomized study. Intensive Care Med 35:1614–1618
  87. Ward MM, McEwen AM, Robbins PM, Bennett MJ (2009) A simple aspiration test to determine the accuracy of oesophageal placement of fine-bore feeding tubes. Intensive Care Med 35:722–724
  88. Doig GS, Heighes PT, Simpson F, Sweetman EA, Davies AR (2009) Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials. Intensive Care Med 35:2018–2027
  89. Kreutziger J, Wenzel V, Kurz A, Constantinescu MA (2009) Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients. Intensive Care Med 35:1234–1239
  90. Cordingley JJ, Vlasselaers D, Dormand NC, Wouters PJ, Squire SD, Chassin LJ, Wilinska ME, Morgan CJ, Hovorka R, Van den Berghe G (2009) Intensive insulin therapy: enhanced model predictive control algorithm versus standard care. Intensive Care Med 35:123–128
  91. Holzinger U, Warszawska J, Kitzberger R, Herkner H, Metnitz PG, Madl C (2009) Impact of shock requiring norepinephrine on the accuracy and reliability of subcutaneous continuous glucose monitoring. Intensive Care Med 35:1383–1389
  92. Eslami S, Abu-Hanna A, de Jonge E, de Keizer NF (2009) Tight glycemic control and computerized decision-support systems: a systematic review. Intensive Care Med 35:1505–1517

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