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Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubationOpen access

Massimo Antonelli| Elie Azoulay| Marc Bonten| Jean Chastre| Giuseppe Citerio| Giorgio Conti| Daniel De Backer| François Lemaire| Herwig Gerlach| Johan Groeneveld| Goran Hedenstierna| Duncan Macrae| Jordi Mancebo| Salvatore M. Maggiore| Alexandre Mebazaa| Philipp Metnitz| Jerôme Pugin| Jan Wernerman| Haibo Zhang
Year in Review 2008
Volume 35, Issue 2 / February , 2009

Pages 215 - 231

No abstract available.


  1. Nin N, Lorente JA, De Paula M, Fernandez-Segoviano P, Penuelas O, Sanchez-Ferrer A, Martinez-Caro L, Esteban A (2008) Aging increases the susceptibility to injurious mechanical ventilation. Intensive Care Med 34:923–931
  2. Badia JR, Ferguson ND (2008) Ventilator-induced lung injury: another sign of aging? Intensive Care Med 34:796–799
  3. Nin N, Lorente JA, de Paula M, El Assar M, Vallejo S, Penuelas O, Fernandez-Segoviano P, Ferruelo A, Sanchez-Ferrer A, Esteban A (2008) Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes. Intensive Care Med 34:948–956
  4. Allardet-Servent J, Bregeon F, Delpierre S, Steinberg JG, Payan MJ, Ravailhe S, Papazian L (2008) High-frequency percussive ventilation attenuates lung injury in a rabbit model of gastric juice aspiration. Intensive Care Med 34:91–100
  5. Beck J, Brander L, Slutsky AS, Reilly MC, Dunn MS, Sinderby C (2008) Non-invasive neurally adjusted ventilatory assist in rabbits with acute lung injury. Intensive Care Med 34:316–323
  6. Meier T, Luepschen H, Karsten J, Leibecke T, Grossherr M, Gehring H, Leonhardt S (2008) Assessment of regional lung recruitment and derecruitment during a PEEP trial based on electrical impedance tomography. Intensive Care Med 34:543–550
  7. Schibler A, Calzia E (2008) Electrical impedance tomography: a future item on the “Christmas Wish List” of the intensivist? Intensive Care Med 34:400–401 author reply 583
  8. Astrom E, Uttman L, Niklason L, Aboab J, Brochard L, Jonson B (2008) Pattern of inspiratory gas delivery affects CO2 elimination in health and after acute lung injury. Intensive Care Med 34:377–384
  9. Schwartges I, Schwarte LA, Fournell A, Scheeren TW, Picker O (2008) Hypercapnia induces a concentration-dependent increase in gastric mucosal oxygenation in dogs. Intensive Care Med 34:1898–1906
  10. Hering R, Bolten JC, Kreyer S, Berg A, Wrigge H, Zinserling J, Putensen C (2008) Spontaneous breathing during airway pressure release ventilation in experimental lung injury: effects on hepatic blood flow. Intensive Care Med 34:523–527
  11. Calzia E, Radermacher P, Pelosi P (2008) Preserved spontaneous breathing in acute lung injury: show me the money? Intensive Care Med 34:397–399
  12. de Prost N, Dreyfuss D, Ricard JD, Saumon G (2008) Terbutaline lessens protein fluxes across the alveolo-capillary barrier during high-volume ventilation. Intensive Care Med 34:763–770
  13. Kuebler WM (2008) Hitting new barriers in ventilator-induced lung injury. Intensive Care Med 34:592–594
  14. Cheung PY, Obaid L, Emara M, Brierley Y, Johnson ST, Chan GS, Jewell L, Korbutt G, Bigam DL (2008) Cardio-renal recovery of hypoxic newborn pigs after 18%, 21% and 100% reoxygenation. Intensive Care Med 34:1114–1121
  15. Douzinas EE, Livaditi O, Andrianakis I, Prigouris P, Paneris P, Villiotou V, Betrosian AP (2008) The effect of hypoxemic resuscitation from hemorrhagic shock on blood pressure restoration and on oxidative and inflammatory responses. Intensive Care Med 34:1133–1141
  16. Joynt C, Bigam DL, Charrois G, Jewell LD, Korbutt G, Cheung PY (2008) Dose–response effects of milrinone on hemodynamics of newborn pigs with hypoxia–reoxygenation. Intensive Care Med 34:1321–1329
  17. Lee TF, Jantzie LL, Todd KG, Cheung PY (2008) Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain. Intensive Care Med 34:190–197
  18. Geeraerts T, Friggeri A, Mazoit JX, Benhamou D, Duranteau J, Vigue B (2008) Posttraumatic brain vulnerability to hypoxia–hypotension: the importance of the delay between brain trauma and secondary insult. Intensive Care Med 34:551–560
  19. Stahel PF, Smith WR, Moore EE (2008) Hypoxia and hypotension, the “lethal duo” in traumatic brain injury: implications for prehospital care. Intensive Care Med 34:402–404
  20. Marbacher S, Neuschmelting V, Graupner T, Jakob SM, Fandino J (2008) Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo. Intensive Care Med 34:932–938
  21. Geiger R, Kleinsasser A, Meier S, Neu N, Pajk W, Fischer V, Treml B, Stein JI, Loeckinger A (2008) Intravenous tezosentan improves gas exchange and hemodynamics in acute lung injury secondary to meconium aspiration. Intensive Care Med 34:368–376
  22. Rex S, Missant C, Segers P, Rossaint R, Wouters PF (2008) Epoprostenol treatment of acute pulmonary hypertension is associated with a paradoxical decrease in right ventricular contractility. Intensive Care Med 34:179–189
  23. Pape A, Kertscho H, Meier J, Horn O, Laout M, Steche M, Lossen M, Theisen A, Zwissler B, Habler O (2008) Improved short-term survival with polyethylene glycol modified hemoglobin liposomes in critical normovolemic anemia. Intensive Care Med 34:1534–1543
  24. Wan L, Yang N, Hiew CY, Schelleman A, Johnson L, May C, Bellomo R (2008) An assessment of the accuracy of renal blood flow estimation by Doppler ultrasound. Intensive Care Med 34:1503–1510
  25. Hagiwara S, Iwasaka H, Matsumoto S, Noguchi T (2008) High dose antithrombin III inhibits HMGB1 and improves endotoxin-induced acute lung injury in rats. Intensive Care Med 34:361–367
  26. Pugin J (2008) Dear Sirs, the concept of “alarmins” makes a lot of sense!. Intensive Care Med 34:218–221
  27. Gibot S, Massin F, Cravoisy A, Barraud D, Nace L, Levy B, Bollaert PE (2007) High-mobility group box 1 protein plasma concentrations during septic shock. Intensive Care Med 33:1347–1353
  28. Karlsson S, Pettila V, Tenhunen J, Laru-Sompa R, Hynninen M, Ruokonen E (2008) HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intensive Care Med 34:1046–1053
  29. Hagiwara S, Iwasaka H, Hasegawa A, Asai N, Noguchi T (2008) High-dose intravenous immunoglobulin G improves systemic inflammation in a rat model of CLP-induced sepsis. Intensive Care Med 34:1812–1819
  30. Haraguchi G, Kosuge H, Maejima Y, Suzuki J, Imai T, Yoshida M, Isobe M (2008) Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis. Intensive Care Med 34:1304–1312
  31. Tuon L, Comim CM, Petronilho F, Barichello T, Izquierdo I, Quevedo J, Dal-Pizzol F (2008) Time-dependent behavioral recovery after sepsis in rats. Intensive Care Med 34:1724–1731
  32. Tuon L, Comim CM, Antunes MM, Constantino LS, Machado RA, Izquierdo I, Quevedo J, Dal-Pizzol F (2007) Imipramine reverses the depressive symptoms in sepsis survivor rats. Intensive Care Med 33:2165–2167
  33. Carvalho D, Petronilho F, Vuolo F, Machado RA, Constantino L, Guerrini R, Calo G, Gavioli EC, Streck EL, Dal-Pizzol F (2008) The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis. Intensive Care Med 34:2284–2290
  34. Frick CG, Fink H, Gordan ML, Eckel B, Martyn JA, Blobner M (2008) Chronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers. Intensive Care Med 34:561–567
  35. Li Y, Cui X, Li X, Solomon SB, Danner RL, Banks SM, Fitz Y, Annane D, Natanson C, Eichacker PQ (2008) Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis. Intensive Care Med 34:568–577
  36. Ellger B, Langouche L, Richir M, Debaveye Y, Vanhorebeek I, Van Leeuwen PA, Van den Berghe G (2008) Modulation of regional nitric oxide metabolism: blood glucose control or insulin? Intensive Care Med 34:1525–1533
  37. Ader F, Le Berre R, Fackeure R, Raze D, Menozzi FD, Viget N, Faure K, Kipnis E, Guery B, Jarraud S, Etienne J, Chidiac C (2008) In vivo effect of adhesion inhibitor heparin on Legionella nemophila pathogenesis in a murine pneumonia model. Intensive Care Med 34:1511–1519
  38. Rossi P, Persson B, Boels PJ, Arner A, Weitzberg E, Oldner A (2008) Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction. Intensive Care Med 34:873–880
  39. Lin HC, Wan FJ (2008) Hyperbaric oxygenation reduces overexpression of c-Fos and oxidative stress in the brain stem of experimental endotoxemic rats. Intensive Care Med 34:1122–1132
  40. Kopel T, Losser MR, Faivre V, Payen D (2008) Systemic and hepatosplanchnic macro- and microcirculatory dose response to arginine vasopressin in endotoxic rabbits. Intensive Care Med 34:1313–1320
  41. Ferrari F, Liu ZH, Lu Q, Becquemin MH, Louchahi K, Aymard G, Marquette CH, Rouby JJ (2008) Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers. Intensive Care Med 34:1718–1723
  42. van den Akker EL, Baan CC, van den Berg B, Russcher H, Joosten K, Hokken-Koelega AC, Lamberts SW, Koper JW (2008) Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytes. Intensive Care Med 34:912–916
  43. Noda A, Kinoshita K, Sakurai A, Matsumoto T, Mugishima H, Tanjoh K (2008) Hyperglycemia and lipopolysaccharide decrease depression effect of interleukin 8 production by hypothermia: an experimental study with endothelial cells. Intensive Care Med 34:109–115
  44. Dos Santos CC (2008) Advances in mechanisms of repair and remodelling in acute lung injury. Intensive Care Med 34:619–630
  45. Negrini D, Passi A, Moriondo A (2008) The role of proteoglycans in pulmonary edema development. Intensive Care Med 34:610–618
  46. Dixon B, Campbell DJ, Santamaria JD (2008) Elevated pulmonary dead space and coagulation abnormalities suggest lung microvascular thrombosis in patients undergoing cardiac surgery. Intensive Care Med 34:1216–1223
  47. Ranucci M (2008) Aprotinin and microvascular thrombosis in cardiac surgery. Intensive Care Med 34:1175–1176
  48. Arcaroli J, Sankoff J, Liu N, Allison DB, Maloney J, Abraham E (2008) Association between urokinase haplotypes and outcome from infection-associated acute lung injury. Intensive Care Med 34:300–307
  49. Cavallazzi R, Nair A, Vasu T, Marik PE (2008) Natriuretic peptides in acute pulmonary embolism: a systematic review. Intensive Care Med 34:2147–2156
  50. Lefebvre A, Kural-Menasche S, Darmon M, Thiery G, Feugeas JP, Schlemmer B, Azoulay E (2008) Use of N-terminal pro-brain natriuretic peptide to detect cardiac origin in critically ill cancer patients with acute respiratory failure. Intensive Care Med 34:833–839
  51. Wagner PD (2008) The multiple inert gas elimination technique (MIGET). Intensive Care Med 34:994–1001
  52. Maniscalco M, Zedda A, Faraone S, Carratu P, Sofia M (2008) Evaluation of a transcutaneous carbon dioxide monitor in severe obesity. Intensive Care Med 34:1340–1344
  53. Meduri GU, Marik PE, Chrousos GP, Pastores SM, Arlt W, Beishuizen A, Bokhari F, Zaloga G, Annane D (2008) Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature. Intensive Care Med 34:61–69
  54. Fernandez R, Trenchs X, Klamburg J, Castedo J, Serrano JM, Besso G, Tirapu JP, Santos A, Mas A, Parraga M, Jubert P, Frutos F, Anon JM, Garcia M, Rodriguez F, Yebenes JC, Lopez MJ (2008) Prone positioning in acute respiratory distress syndrome: a multicenter randomized clinical trial. Intensive Care Med 34:1487–1491
  55. Abroug F, Ouanes-Besbes L, Elatrous S, Brochard L (2008) The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research. Intensive Care Med 34:1002–1011
  56. Standley TD, Smith HL, Brennan LJ, Wilkins IA, Bradley PG, Barrera Groba C, Davey AJ, Menon DK, Wheeler DW (2008) Room air dilution of heliox given by facemask. Intensive Care Med 34:1469–1476
  57. Gosselink R, Bott J, Johnson M, Dean E, Nava S, Norrenberg M, Schonhofer B, Stiller K, van de Leur H, Vincent JL (2008) Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for critically ill patients. Intensive Care Med 34:1188–1199
  58. Vassilakopoulos T (2008) Ventilator-induced diaphragm dysfunction: the clinical relevance of animal models. Intensive Care Med 34:7–16
  59. Pelosi P, Rocco PR (2008) Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med 34:631–639
  60. Burns KE, Lellouche F, Lessard MR (2008) Automating the weaning process with advanced closed-loop systems. Intensive Care Med 34:1757–1765
  61. Arnal JM, Wysocki M, Nafati C, Donati S, Granier I, Corno G, Durand-Gasselin J (2008) Automatic selection of breathing pattern using adaptive support ventilation. Intensive Care Med 34:75–81
  62. Rose L, Presneill JJ, Johnston L, Cade JF (2008) A randomised, controlled trial of conventional versus automated weaning from mechanical ventilation using SmartCare trade mark/PS. Intensive Care Med 34:1788–1795
  63. Laghi F (2008) Weaning: can the computer help? Intensive Care Med 34:1746–1748
  64. Prinianakis G, Plataki M, Kondili E, Klimathianaki M, Vaporidi K, Georgopoulos D (2008) Effects of relaxation of inspiratory muscles on ventilator pressure during pressure support. Intensive Care Med 34:70–74
  65. Younes M (2008) Why does airway pressure rise sometimes near the end of inflation during pressure support? Intensive Care Med 34:1–3
  66. Demory D, Arnal JM, Wysocki M, Donati S, Granier I, Corno G, Durand-Gasselin J (2008) Recruitability of the lung estimated by the pressure volume curve hysteresis in ARDS patients. Intensive Care Med 34:2019–2025
  67. Patroniti N, Saini M, Zanella A, Weismann D, Isgro S, Bellani G, Foti G, Pesenti A (2008) Measurement of end-expiratory lung volume by oxygen washin-washout in controlled and assisted mechanically ventilated patients. Intensive Care Med 34:2235–2240
  68. Reske AW, Busse H, Amato MB, Jaekel M, Kahn T, Schwarzkopf P, Schreiter D, Gottschaldt U, Seiwerts M (2008) Image reconstruction affects computer tomographic assessment of lung hyperinflation. Intensive Care Med 34:2044–2053
  69. Rodrigues RS, Miller PR, Bozza FA, Marchiori E, Zimmerman GA, Hoffman JM, Morton KA (2008) FDG-PET in patients at risk for acute respiratory distress syndrome: a preliminary report. Intensive Care Med 34:2273–2278
  70. Clec’h C, Simon P, Hamdi A, Hamza L, Karoubi P, Fosse JP, Gonzalez F, Vincent F, Cohen Y (2008) Are daily routine chest radiographs useful in critically ill, mechanically ventilated patients? A randomized study. Intensive Care Med 34:264–270
  71. El-Khatib MF, Zeineldine SM, Jamaleddine GW (2008) Effect of pressure support ventilation and positive end expiratory pressure on the rapid shallow breathing index in intensive care unit patients. Intensive Care Med 34:505–510
  72. Rusterholtz T, Bollaert PE, Feissel M, Romano-Girard F, Harlay ML, Zaehringer M, Dusang B, Sauder P (2008) Continuous positive airway pressure vs. proportional assist ventilation for noninvasive ventilation in acute cardiogenic pulmonary edema. Intensive Care Med 34:840–846
  73. Ferreira JC, Chipman DW, Kacmarek RM (2008) Trigger performance of mid-level ICU mechanical ventilators during assisted ventilation: a bench study. Intensive Care Med 34:1669–1675
  74. Thille AW, Cabello B, Galia F, Lyazidi A, Brochard L (2008) Reduction of patient–ventilator asynchrony by reducing tidal volume during pressure-support ventilation. Intensive Care Med 34:1477–1486
  75. Rose L, Hawkins M (2008) Airway pressure release ventilation and biphasic positive airway pressure: a systematic review of definitional criteria. Intensive Care Med 34:1766–1773
  76. Mojoli F, Iotti GA, Gerletti M, Lucarini C, Braschi A (2008) Carbon dioxide rebreathing during non-invasive ventilation delivered by helmet: a bench study. Intensive Care Med 34:1454–1460
  77. Racca F, Appendini L, Gregoretti C, Varese I, Berta G, Vittone F, Ferreyra G, Stra E, Ranieri VM (2008) Helmet ventilation and carbon dioxide rebreathing: effects of adding a leak at the helmet ports. Intensive Care Med 34:1461–1468
  78. Moerer O, Beck J, Brander L, Costa R, Quintel M, Slutsky AS, Brunet F, Sinderby C (2008) Subject–ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med 34:1615–1623
  79. Xirouchaki N, Kondili E, Vaporidi K, Xirouchakis G, Klimathianaki M, Gavriilidis G, Alexandopoulou E, Plataki M, Alexopoulou C, Georgopoulos D (2008) Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support. Intensive Care Med 34:2026–2034
  80. Colombo D, Cammarota G, Bergamaschi V, De Lucia M, Corte FD, Navalesi P (2008) Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure. Intensive Care Med 34:2010–2018
  81. Carvalho AR, Spieth PM, Pelosi P, Vidal Melo MF, Koch T, Jandre FC, Giannella-Neto A, de Abreu MG (2008) Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration. Intensive Care Med 34:2291–2299
  82. Dellamonica J, Louis B, Lyazidi A, Vargas F, Brochard L (2008) Intrapulmonary percussive ventilation superimposed on conventional ventilation: bench study of humidity and ventilator behaviour. Intensive Care Med 34:2035–2043
  83. Andrieu MC, Quentin C, Orlikowski D, Desmarais G, Isabey D, Louis B, Lofaso F (2008) Inductive plethysmography to control volume-targeted ventilation for leak compensation. Intensive Care Med 34:1150–1155
  84. Lovat R, Watremez C, Van Dyck M, Van Caenegem O, Verschuren F, Hantson P, Jacquet LM (2008) Smart bag vs. standard bag in the temporary substitution of the mechanical ventilation. Intensive Care Med 34:355–360
  85. Beecroft JM, Ward M, Younes M, Crombach S, Smith O, Hanly PJ (2008) Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography. Intensive Care Med 34:2076–2083
  86. Griesdale DE, Bosma TL, Kurth T, Isac G, Chittock DR (2008) Complications of endotracheal intubation in the critically ill. Intensive Care Med 34:1835–1842
  87. Zanella A, Cressoni M, Epp M, Stylianou M, Kolobow T (2008) A double-layer tracheal tube cuff designed to prevent leakage: a bench-top study. Intensive Care Med 34:1145–1149
  88. Fernandez R, Bacelar N, Hernandez G, Tubau I, Baigorri F, Gili G, Artigas A (2008) Ward mortality in patients discharged from the ICU with tracheostomy may depend on patient’s vulnerability. Intensive Care Med 34:1878–1882
  89. Blot F, Similowski T, Trouillet JL, Chardon P, Korach JM, Costa MA, Journois D, Thiery G, Fartoukh M, Pipien I, Bruder N, Orlikowski D, Tankere F, Durand-Zaleski I, Auboyer C, Nitenberg G, Holzapfel L, Tenaillon A, Chastre J, Laplanche A (2008) Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med 34:1779–1787
  90. Scales DC, Kahn JM (2008) Tracheostomy timing, enrollment and power in ICU clinical trials. Intensive Care Med 34:1743–1745

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