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Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumoniaOpen access

Massimo Antonelli| Elie Azoulay| Marc Bonten| Jean Chastre| Giuseppe Citerio| Giorgio Conti| Daniel De Backer| François Lemaire| Herwig Gerlach| Johan Groeneveld| Goran Hedenstierna| Duncan Macrae| Jordi Mancebo| Salvatore M. Maggiore| Alexandre Mebazaa| Philipp Metnitz| Jerôme Pugin| Jan Wernerman| Haibo Zhang
Year in Review 2008
Volume 35, Issue 1 / January , 2009

Pages 30 - 44

No abstract available.


  1. Vilalta A, Sahuquillo J, Rosell A, Poca MA, Riveiro M, Montaner J (2008) Moderate and severe traumatic brain injury induce early overexpression of systemic and brain gelatinases. Intensive Care Med 34:1384–1392
  2. Mascia L, Sakr Y, Pasero D, Payen D, Reinhart K, Vincent JL (2008) Extracranial complications in patients with acute brain injury: a post-hoc analysis of the SOAP study. Intensive Care Med 34:720–727
  3. Mauritz W, Steltzer H, Bauer P, Dolanski-Aghamanoukjan L, Metnitz P (2008) Monitoring of intracranial pressure in patients with severe traumatic brain injury: an Austrian prospective multicenter study. Intensive Care Med 34:1208–1215
  4. Geeraerts T, Merceron S, Benhamou D, Vigue B, Duranteau J (2008) Non-invasive assessment of intracranial pressure using ocular sonography in neurocritical care patients. Intensive Care Med 34:2062–2067
  5. Stocchetti N, Zanaboni C, Colombo A, Citerio G, Beretta L, Ghisoni L, Zanier ER, Canavesi K (2008) Refractory intracranial hypertension and “second-tier” therapies in traumatic brain injury. Intensive Care Med 34:461–467
  6. Neumann JO, Chambers IR, Citerio G, Enblad P, Gregson BA, Howells T, Mattern J, Nilsson P, Piper I, Ragauskas A, Sahuquillo J, Yau YH, Kiening K (2008) The use of hyperventilation therapy after traumatic brain injury in Europe: an analysis of the BrainIT database. Intensive Care Med 34:1676–1682
  7. Maiya B, Newcombe V, Nortje J, Bradley P, Bernard F, Chatfield D, Outtrim J, Hutchinson P, Matta B, Antoun N, Menon D (2008) Magnetic resonance imaging changes in the pituitary gland following acute traumatic brain injury. Intensive Care Med 34:468–475
  8. Andrews PJ, Citerio G, Longhi L, Polderman K, Sahuquillo J, Vajkoczy P (2008) NICEM consensus on neurological monitoring in acute neurological disease. Intensive Care Med 34:1362–1370
  9. Schlenk F, Nagel A, Graetz D, Sarrafzadeh AS (2008) Hyperglycemia and cerebral glucose in aneurysmal subarachnoid hemorrhage. Intensive Care Med 34:1200–1207
  10. Strong AJ (2008) The management of plasma glucose in acute cerebral ischaemia and traumatic brain injury: more research needed. Intensive Care Med 34:1169–1172
  11. Legriel S, Mourvillier B, Bele N, Amaro J, Fouet P, Manet P, Hilpert F (2008) Outcomes in 140 critically ill patients with status epilepticus. Intensive Care Med 34:476–480
  12. Walsh TS, Ramsay P, Lapinlampi TP, Sarkela MO, Viertio-Oja HE, Merilainen PT (2008) An assessment of the validity of spectral entropy as a measure of sedation state in mechanically ventilated critically ill patients. Intensive Care Med 34:308–315
  13. Morandi A, Pandharipande P, Trabucchi M, Rozzini R, Mistraletti G, Trompeo AC, Gregoretti C, Gattinoni L, Ranieri MV, Brochard L, Annane D, Putensen C, Guenther U, Fuentes P, Tobar E, Anzueto AR, Esteban A, Skrobik Y, Salluh JI, Soares M, Granja C, Stubhaug A, de Rooij SE, Ely EW (2008) Understanding international differences in terminology for delirium and other types of acute brain dysfunction in critically ill patients. Intensive Care Med 34:1907–1915
  14. Cheung CZ, Alibhai SM, Robinson M, Tomlinson G, Chittock D, Drover J, Skrobik Y (2008) Recognition and labeling of delirium symptoms by intensivists: does it matter? Intensive Care Med 34:437–446
  15. Plaschke K, von Haken R, Scholz M, Engelhardt R, Brobeil A, Martin E, Weigand MA (2008) Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the Intensive Care Delirium Screening Checklist (ICDSC) for delirium in critical care patients gives high agreement rate(s). Intensive Care Med 34:431–436
  16. Soja SL, Pandharipande PP, Fleming SB, Cotton BA, Miller LR, Weaver SG, Lee BT, Ely EW (2008) Implementation, reliability testing, and compliance monitoring of the Confusion Assessment Method for the Intensive Care Unit in trauma patients. Intensive Care Med 34:1263–1268
  17. Brimioulle S, Orellana-Jimenez C, Aminian A, Vincent JL (2008) Hyponatremia in neurological patients: cerebral salt wasting versus inappropriate antidiuretic hormone secretion. Intensive Care Med 34:125–131
  18. Hausfater P, Hurtado M, Pease S, Juillien G, Lvovschi VE, Salehabadi S, Lidove O, Wolff M, Bernard M, Chollet-Martin S, Riou B (2008) Is procalcitonin a marker of critical illness in heatstroke? Intensive Care Med 34:1377–1383
  19. Vinclair M, Broux C, Faure P, Brun J, Genty C, Jacquot C, Chabre O, Payen JF (2008) Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med 34:714–719
  20. du Cheyron D, Bouchet B, Cauquelin B, Guillotin D, Ramakers M, Daubin C, Ballet JJ, Charbonneau P (2008) Hyperreninemic hypoaldosteronism syndrome, plasma concentrations of interleukin-6 and outcome in critically ill patients with liver cirrhosis. Intensive Care Med 34:116–124
  21. Malbrain ML, De laet I, Viaene D, Schoonheydt K, Dits H (2008) In vitro validation of a novel method for continuous intra-abdominal pressure monitoring. Intensive Care Med 34:740–745
  22. Heemskerk S, van Haren FM, Foudraine NA, Peters WH, van der Hoeven JG, Russel FG, Masereeuw R, Pickkers P (2008) Short-term beneficial effects of methylene blue on kidney damage in septic shock patients. Intensive Care Med 34:350–354
  23. Boussekey N, Chiche A, Faure K, Devos P, Guery B, d’Escrivan T, Georges H, Leroy O (2008) A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock. Intensive Care Med 34:1646–1653
  24. Cantaluppi V, Assenzio B, Pasero D, Romanazzi GM, Pacitti A, Lanfranco G, Puntorieri V, Martin EL, Mascia L, Monti G, Casella G, Segoloni GP, Camussi G, Ranieri VM (2008) Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors. Intensive Care Med 34:1638–1645
  25. Wu VC, Ko WJ, Chang HW, Chen YW, Lin YF, Shiao CC, Chen YM, Chen YS, Tsai PR, Hu FC, Wang JY, Lin YH, Wu KD (2008) Risk factors of early redialysis after weaning from postoperative acute renal replacement therapy. Intensive Care Med 34:101–108
  26. Ronco C, House AA, Haapio M (2008) Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong. Intensive Care Med 34:957–962
  27. Ronco C, Ricci Z (2008) Renal replacement therapies: physiological review. Intensive Care Med 34:2139–2146
  28. Lanquetot H, Leprince T, Ragot S, Boinot C, Jayle C, Robert R, Macchi L (2008) Antithrombin level and circuit thrombosis during hemofiltration after cardiopulmonary bypass. Intensive Care Med 34:2068–2075
  29. Honiden S, Schultz A, Im SA, Nierman DM, Gong MN (2008) Early versus late intravenous insulin administration in critically ill patients. Intensive Care Med 34:881–887
  30. Pachler C, Plank J, Weinhandl H, Chassin LJ, Wilinska ME, Kulnik R, Kaufmann P, Smolle KH, Pilger E, Pieber TR, Ellmerer M, Hovorka R (2008) Tight glycaemic control by an automated algorithm with time-variant sampling in medical ICU patients. Intensive Care Med 34:1224–1230
  31. Vogelzang M, Loef BG, Regtien JG, van der Horst IC, van Assen H, Zijlstra F, Nijsten MW (2008) Computer-assisted glucose control in critically ill patients. Intensive Care Med 34:1421–1427
  32. Iapichino G, Albicini M, Umbrello M, Sacconi F, Fermo I, Pavlovich R, Paroni R, Bellani G, Mistraletti G, Cugno M, Pesenti A, Gattinoni L (2008) Tight glycemic control does not affect asymmetric-dimethylarginine in septic patients. Intensive Care Med 34:1843–1850
  33. Panlaqui OM, Tran K, Johns A, McGill J, White H (2008) Acute hyperammonemic encephalopathy in adult onset ornithine transcarbamylase deficiency. Intensive Care Med 34:1922–1924
  34. Nguyen NQ, Fraser RJ, Bryant LK, Chapman M, Holloway RH (2008) Diminished functional association between proximal and distal gastric motility in critically ill patients. Intensive Care Med 34:1246–1255
  35. Nguyen NQ, Chapman MJ, Fraser RJ, Bryant LK, Burgstad C, Ching K, Bellon M, Holloway RH (2008) The effects of sedation on gastric emptying and intra-gastric meal distribution in critical illness. Intensive Care Med 34:454–460
  36. Desachy A, Clavel M, Vuagnat A, Normand S, Gissot V, Francois B (2008) Initial efficacy and tolerability of early enteral nutrition with immediate or gradual introduction in intubated patients. Intensive Care Med 34:1054–1059
  37. Nguyen NQ, Ching K, Fraser RJ, Chapman MJ, Holloway RH (2008) Risk of Clostridium difficile diarrhoea in critically ill patients treated with erythromycin-based prokinetic therapy for feed intolerance. Intensive Care Med 34:169–173
  38. Marik PE, Zaloga GP (2008) Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med 34:1980–1990
  39. Friesecke S, Lotze C, Kohler J, Heinrich A, Felix SB, Abel P (2008) Fish oil supplementation in the parenteral nutrition of critically ill medical patients: a randomised controlled trial. Intensive Care Med 34:1411–1420
  40. Singer P, Shapiro H, Theilla M, Anbar R, Singer J, Cohen J (2008) Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective. Intensive Care Med 34:1580–1592
  41. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 34:17–60
  42. Vaschetto R, Nicola S, Olivieri C, Boggio E, Piccolella F, Mesturini R, Damnotti F, Colombo D, Navalesi P, Della Corte F, Dianzani U, Chiocchetti A (2008) Serum levels of osteopontin are increased in SIRS and sepsis. Intensive Care Med 34:2176–2184
  43. Dulhunty JM, Lipman J, Finfer S (2008) Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study. Intensive Care Med 34:1654–1661
  44. de Kruif MD, Lemaire LC, Giebelen IA, Struck J, Morgenthaler NG, Papassotiriou J, Elliott PJ, van der Poll T (2008) The influence of corticosteroids on the release of novel biomarkers in human endotoxemia. Intensive Care Med 34:518–522
  45. O’Dwyer MJ, Mankan AK, White M, Lawless MW, Stordeur P, O’Connell B, Kelleher DP, McManus R, Ryan T (2008) The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. Intensive Care Med 34:683–691
  46. Schippers EF, Berbee JF, van Disseldorp IM, Versteegh MI, Havekes LM, Rensen PC, van Dissel JT (2008) Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery. Intensive Care Med 34:1492–1497
  47. Payen D, Lukaszewicz AC, Belikova I, Faivre V, Gelin C, Russwurm S, Launay JM, Sevenet N (2008) Gene profiling in human blood leucocytes during recovery from septic shock. Intensive Care Med 34:1371–1376
  48. Moreno RP, Metnitz B, Adler L, Hoechtl A, Bauer P, Metnitz PG (2008) Sepsis mortality prediction based on predisposition, infection and response. Intensive Care Med 34:496–504
  49. Seligman R, Papassotiriou J, Morgenthaler NG, Meisner M, Teixeira PJ (2008) Prognostic value of midregional pro-atrial natriuretic peptide in ventilator-associated pneumonia. Intensive Care Med 34:2084–2091
  50. Berbee JF, van der Hoogt CC, de Haas CJ, van Kessel KP, Dallinga-Thie GM, Romijn JA, Havekes LM, van Leeuwen HJ, Rensen PC (2008) Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis. Intensive Care Med 34:907–911
  51. Kaufmann I, Briegel J, Schliephake F, Hoelzl A, Chouker A, Hummel T, Schelling G, Thiel M (2008) Stress doses of hydrocortisone in septic shock: beneficial effects on opsonization-dependent neutrophil functions. Intensive Care Med 34:344–349
  52. Vandijck DM, Benoit DD, Depuydt PO, Offner FC, Blot SI, Van Tilborgh AK, Nollet J, Steel E, Noens LA, Decruyenaere JM (2008) Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies. Intensive Care Med 34:847–855
  53. Kalil AC, Sun J (2008) How many patients with severe sepsis are needed to confirm the efficacy of drotrecogin alfa activated? A Bayesian design. Intensive Care Med 34:1804–1811
  54. Finfer S, Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Gardlund B, Marshall JC, Rhodes A (2008) Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med 34:1935–1947
  55. Mancebo J, Antonelli M (2008) Editors’ comments on a new trial of activated protein C for persistent septic shock. Intensive Care Med 34:1948–1949
  56. Suter PM, Takala J (2008) Science, medicine and industry: are we getting out of the black hole in sepsis research? Intensive Care Med 34:1950–1954
  57. Sweeney DA, Danner RL, Eichacker PQ, Natanson C (2008) Once is not enough: clinical trials in sepsis. Intensive Care Med 34:1955–1960
  58. Gowardman JR, Robertson IK, Parkes S, Rickard CM (2008) Influence of insertion site on central venous catheter colonization and bloodstream infection rates. Intensive Care Med 34:1038–1045
  59. Khalifa R, Dahyot-Fizelier C, Laksiri L, Ragot S, Petitpas F, Nanadoumgar H, Debaene B, Mimoz O (2008) Indwelling time and risk of colonization of peripheral arterial catheters in critically ill patients. Intensive Care Med 34:1820–1826
  60. Garnacho-Montero J, Aldabo-Pallas T, Palomar-Martinez M, Valles J, Almirante B, Garces R, Grill F, Pujol M, Arenas-Gimenez C, Mesalles E, Escoresca-Ortega A, de Cueto M, Ortiz-Leyba C (2008) Risk factors and prognosis of catheter-related bloodstream infection in critically ill patients: a multicenter study. Intensive Care Med 34:2185–2193
  61. Souweine B, Heng AE, Aumeran C, Thiolliere F, Gazuy N, Deteix P, Traore O (2008) Do antibiotics administered at the time of central venous catheter removal interfere with the evaluation of colonization? Intensive Care Med 34:286–291
  62. Ho KM, Lee KY, Dobb GJ, Webb SA (2008) C-reactive protein concentration as a predictor of in-hospital mortality after ICU discharge: a prospective cohort study. Intensive Care Med 34:481–487
  63. Linssen CF, Jacobs JA, Stelma FF, van Mook WN, Terporten P, Vink C, Drent M, Bruggeman CA, Smismans A (2008) Herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients. Intensive Care Med 34:2202–2209
  64. Boer KR, van Ruler O, van Emmerik AA, Sprangers MA, de Rooij SE, Vroom MB, de Borgie CA, Boermeester MA, Reitsma JB (2008) Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram. Intensive Care Med 34:664–674
  65. Villar J, Flores C, Pérez-Méndez L, Maca-Meyer N, Espinosa E, Blanco J, Sangüesa R, Muriel A, Tejera P, Muros M, Slutsky AS, GRECIA group, GEN-SEP group (2008) Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome. Intensive Care Med 34:488–495
  66. Mol M, van Kan HJ, Schultz MJ, de Jonge E (2008) Systemic tobramycin concentrations during selective decontamination of the digestive tract in intensive care unit patients on continuous venovenous hemofiltration. Intensive Care Med 34:903–906
  67. Langgartner J, Vasold A, Gluck T, Reng M, Kees F (2008) Pharmacokinetics of meropenem during intermittent and continuous intravenous application in patients treated by continuous renal replacement therapy. Intensive Care Med 34:1091–1096
  68. Cholley P, Thouverez M, Floret N, Bertrand X, Talon D (2008) The role of water fittings in intensive care rooms as reservoirs for the colonization of patients with Pseudomonas aeruginosa. Intensive Care Med 34:1428–1433
  69. Bougnoux ME, Kac G, Aegerter P, d’Enfert C, Fagon JY (2008) Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome. Intensive Care Med 34:292–299
  70. Najjar-Pellet J, Jonquet O, Jambou P, Fabry J (2008) Quality assessment in intensive care units: proposal for a scoring system in terms of structure and process. Intensive Care Med 34:278–285
  71. Sonneville R, Demeret S, Klein I, Bouadma L, Mourvillier B, Audibert J, Legriel S, Bolgert F, Regnier B, Wolff M (2008) Acute disseminated encephalomyelitisin the intensive care unit: clinical features and outcome of 20 adults. Intensive Care Med 34:528–532
  72. Damas P, Ledoux D, Nys M, Monchi M, Wiesen P, Beauve B, Preiser JC (2008) Intensive care unit acquired infection and organ failure. Intensive Care Med 34:856–864
  73. Ehrmann S, Mercier E, Vecellio L, Ternant D, Paintaud G, Dequin PF (2008) Pharmacokinetics of high-dose nebulized amikacin in mechanically ventilated healthy subjects. Intensive Care Med 34:755–762
  74. Hutschala D, Kinstner C, Skhirtladze K, Mayer-Helm BX, Zeitlinger M, Wisser W, Muller M, Tschernko E (2008) The impact of perioperative atelectasis on antibiotic penetration into lung tissue: an in vivo microdialysis study. Intensive Care Med 34:1827–1834
  75. Depuydt P, Benoit D, Vogelaers D, Decruyenaere J, Vandijck D, Claeys G, Verschraegen G, Blot S (2008) Systematic surveillance cultures as a tool to predict involvement of multidrug antibiotic resistant bacteria in ventilator-associated pneumonia. Intensive Care Med 34:675–682
  76. Papadomichelakis E, Kontopidou F, Antoniadou A, Poulakou G, Koratzanis E, Kopterides P, Mavrou I, Armaganidis A, Giamarellou H (2008) Screening for resistant gram-negative microorganisms to guide empiric therapy of subsequent infection. Intensive Care Med 34:2169–2175
  77. Batra R, Eziefula AC, Wyncoll D, Edgeworth J (2008) Throat and rectal swabs may have an important role in MRSA screening of critically ill patients. Intensive Care Med 34:1703–1706
  78. Visscher S, Schurink CA, Melsen WG, Lucas PJ, Bonten MJ (2008) Effects of systemic antibiotic therapy on bacterial persistence in the respiratory tract of mechanically ventilated patients. Intensive Care Med 34:692–699
  79. Shu CC, Lee CH, Wang JY, Jerng JS, Yu CJ, Hsueh PR, Lee LN, Yang PC (2008) Nontuberculous mycobacteria pulmonary infection in medical intensive care unit: the incidence, patient characteristics, and clinical significance. Intensive Care Med 34:2194–2201
  80. Luyt CE, Combes A, Reynaud C, Hekimian G, Nieszkowska A, Tonnellier M, Aubry A, Trouillet JL, Bernard M, Chastre J (2008) Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia. Intensive Care Med 34:1434–1440
  81. El Solh AA, Akinnusi ME, Peter M, Berim I, Schultz MJ, Pineda L (2008) Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes. Intensive Care Med 34:1012–1019
  82. Linssen CF, Jacobs JA, Schouten JS, van Mook WN, Ramsay G, Drent M (2008) Influence of antibiotic therapy on the cytological diagnosis of ventilator-associated pneumonia. Intensive Care Med 34:865–872
  83. Berra L, Curto F, Li Bassi G, Laquerriere P, Pitts B, Baccarelli A, Kolobow T (2008) Antimicrobial-coated endotracheal tubes: an experimental study. Intensive Care Med 34:1020–1029
  84. Berra L, Kolobow T, Laquerriere P, Pitts B, Bramati S, Pohlmann J, Marelli C, Panzeri M, Brambillasca P, Villa F, Baccarelli A, Bouthors S, Stelfox HT, Bigatello LM, Moss J, Pesenti A (2008) Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial. Intensive Care Med 34:1030–1037

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