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Year in review in Intensive Care Medicine—2003 : Part 3: Intensive care unit organization, scoring, quality of life, ethics, neonatal and pediatrics, and experimentalOpen access

Edward Abraham| Peter Andrews| Massimo Antonelli| Laurent Brochard| Christian Brun-Buisson| Geoffrey Dobb| Jean-Yves Fagon| Johan Groeneveld| Jordi Mancebo| Philipp Metnitz| Stefano Nava| Michael Pinsky| Peter Radermacher| Marco Ranieri| Christian Richard| Robert Tasker| Benoit Vallet
Special Article
Volume 30, Issue 8 / August , 2004

Pages 1514 - 1525

No abstract available.


  1. Halonen KI, Pettila V, Leppaniemi AK, Kemppainen EA, Puolakkainen PA, Haapiainen RK (2003) Long-term health-related quality of life in survivors of severe acute pancreatitis. Intensive Care Med 29:782–786
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  2. Vincent J-L, Jacobs F (2003) Infection in critically ill patients: clinical impact and management. Intensive Care Med 16:309–313
  3. Kaarlola A, Pettila V, Kekki P (2003) Quality of life six years after intensive care. Intensive Care Med 29:1294–1299
  4. Granja C, Morujao E, Costa-Pereira A (2003) Quality of life in acute respiratory distress syndrome survivors may be no worst than in other ICU survivors. Intensive Care Med 29:1744–1750
  5. Kvale R, Ulvik A, Flaatten H (2003) Follow-up after intensive care: a single center study. Intensive Care Med 29:2149–2156
  6. Somme D, Maillet JM, Gisselbrecht M, Novara A, Ract C, Fagon JY (2003) Critically ill old and the oldest-old patients in intensive care: short- and long-term outcomes. Intensive Care Med 29:2137–2143
  7. Hofhuis J, Hautvast JL, Schrijvers AJ, Bakker J (2003) Quality of life on admission to the intensive care: can we query the relatives? Intensive Care Med 29:974–979
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  8. Heyland DK, Cook DJ, Rocker GM, Dodek PM, Kutsogiannis DJ, Peters S, Tranmer JE, O’Callaghan CJ (2003) Decision-making in the ICU: perspectives of the substitute decision-maker. Intensive Care Med 29:75–82
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  9. Azoulay E, Pochard F, Chevret S, Arich C, Brivet F, Brun F, Charles PE, Desmettre T, Dubois D, Galliot R, Garrouste-Orgeas M, Goldgran-Toledano D, Herbecq P, Joly LM, Jourdain M, Kaidomar M, Lepape A, Letellier N, Marie O, Page B, Parrot A, Rodie-Talbere PA, Sermet A, Tenaillon A, Thuong M, Tulasne P, Le Gall JR, Schlemmer B (2003) Family participation in care to the critically ill: opinions of families and staff. Intensive Care Med 29:1498–1504
  10. Beck DH, Smith GB, Pappachan JV, Millar B (2003) External validation of the SAPS II, APACHE II and APACHE III prognostic models in South England: a multicentre study. Intensive Care Med 29:249–256
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  11. Glance LG, Dick AW, Osler TM, Mukamel D (2003) Using hierarchical modeling to measure ICU quality. Intensive Care Med 29:2223–2229
  12. Buckley TA, Gomersall CD, Ramsay SJ (2003) Validation of the multiple organ dysfunction (MOD) score in critically ill medical and surgical patients. Intensive Care Med 29:2216–2222
  13. Metnitz PG, Fieux F, Jordan B, Lang T, Moreno R, Le Gall JR (2003) Critically ill patients readmitted to intensive care units—lessons to learn? Intensive Care Med 29:241–248
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  14. Garrouste-Orgeas M, Montuclard L, Timsit JF, Misset B, Christias M, Carlet J (2003) Triaging patients to the ICU: a pilot study of factors influencing admission decisions and patient outcomes. Intensive Care Med 29:774–781
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  15. Iapichino G, Morabito A, Mistraletti G, Ferla L, Radrizzani D, Reis Miranda D (2003) Determinants of post-intensive care mortality in high-level treated critically ill patients. Intensive Care Med 29:1751–1756
  16. Uusaro A, Kari A, Ruokonen E (2003) The effects of ICU admission and discharge times on mortality in Finland. Intensive Care Med 29:2144–2148
  17. Azoulay E, Pochard F, Garrouste-Orgeas M, Moreau D, Montesino L, Adrie C, de Lassence A, Cohen Y, Timsit JF (2003) Decisions to forgo life-sustaining therapy in ICU patients independently predict hospital death. Intensive Care Med 29:1895–1901
  18. Giannini A, Pessina A, Tacchi EM (2003) End-of-life decisions in intensive care units: attitudes of physicians in an Italian urban setting. Intensive Care Med 29.1902–1910
  19. Studdert DM, Mello MM, Burns JP, Puopolo AL, Galper BZ, Truog RD, Brennan TA (2003) Conflict in the care of patients with prolonged stay in the ICU: types, sources and predictors. Intensive Care Med 29:1489–1497
  20. Bosman RJ, Rood E, Oudemans-van Straaten HM, Van der Spoel JI, Wester JP, Zandstra DF (2003) Intensive care information system reduces documentation time of the nurses after cardiothoracic surgery. Intensive Care Med 29:83–90
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  21. Slater A, Shann F, Pearson G (2003) PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med 29:278–285
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  22. Slater A, Shann F, McEniery J (2003) The ANZPIC registry diagnostic codes: a system for coding reasons for admitting children to intensive care. Intensive Care Med 29:271–277
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  23. Kuppermann N, Malley R, Huskins WC (2003) A new prognostic scoring system for meningococcal septic shock in children: comparison with three other scoring systems. Intensive Care Med 29:333; author’s reply 334
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  24. Lamas A, Otheo E, Ros P, Vazquez JL, Maldonado MS, Munoz A, Martos I (2003) Prognosis of child recipients of hematopoietic stem cell transplantation requiring intensive care. Intensive Care Med 29:91–96
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  25. Anton N, Joffe KM, Joffe AR (2003) Inability to predict outcome of acute respiratory distress syndrome in children when using high frequency oscillation. Intensive Care Med 29:1763–1769
  26. Vos GD, Nieman FH, Meurs AM, Van Waardenburg DA, Ramsay G, Donckerwolcke RA (2003) Problems in interhospital pediatric intensive care transport in The Netherlands: results from a survey of general pediatricians. Intensive Care Med 29:1555–1559
  27. Hatherill M, Waggie Z, Reynolds L, Argent A (2003) Transport of critically ill children in a resource-limited setting. Intensive Care Med 29:1547–1554
  28. Duke T (2003) Transport of seriously ill children: a neglected global issue. Intensive Care Med 29:1414–1416
  29. Taylor A, Butt W, Ciardulli M (2003) The functional outcome and quality of life of children after admission to an intensive care unit. Intensive Care Med 29:795–800
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  30. Goh AY, Abdel-Latif Mel A, Lum LC, Abu-Bakar MN (2003) Outcome of children with different accessibility to tertiary pediatric intensive care in a developing country—a prospective cohort study. Intensive Care Med 29:97–102
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  31. Hammer J, Patel N, Newth CJ (2003) Effect of forced deflation maneuvers upon measurements of respiratory mechanics in ventilated infants. Intensive Care Med 29:2004–2008
  32. Huckstadt T, Foitzik B, Wauer RR, Schmalisch G (2003) Comparison of two different CPAP systems by tidal breathing parameters. Intensive Care Med 29:1134–1140
  33. Plotz FB, Hassing MB, Sibarani-Ponsen RD, Markhorst DG (2003) Differentiated HFO and CMV for independent lung ventilation in a pediatric patient. Intensive Care Med 29:1855
  34. Gregor T, Schmalisch G, Burkhardt W, Proquitte H, Wauer RR, Rudiger M (2003) Aerosolization of perfluorocarbons during mechanical ventilation: an in vitro study. Intensive Care Med 29:1354–1360
  35. Hilgendorff A, Rawer D, Doerner M, Tutdibi E, Ebsen M, Schmidt R, Guenther A, Gortner L, Reiss I (2003) Synthetic and natural surfactant differentially modulate inflammation after meconium aspiration. Intensive Care Med 29:2247–2254
  36. Moller JC, Schaible T, Roll C, Schiffmann JH, Bindl L, Schrod L, Reiss I, Kohl M, Demirakca S, Hentschel R, Paul T, Vierzig A, Groneck P, von Seefeld H, Schumacher H, Gortner L (2003) Treatment with bovine surfactant in severe acute respiratory distress syndrome in children: a randomized multicenter study. Intensive Care Med 29:437–446
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  37. Noizet O, Leclerc F, Leteurtre S, Brichet A, Pouessel G, Dorkenoo A, Fourier C, Cremer R (2003) Plastic bronchitis mimicking foreign body aspiration that needs a specific diagnostic procedure. Intensive Care Med 29:329–331
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  38. Chew MS, Poelaert J (2003) Accuracy and repeatability of pediatric cardiac output measurement using Doppler: 20-year review of the literature. Intensive Care Med 29:1889–1894
  39. Stocker C, Penny DJ, Brizard CP, Cochrane AD, Soto R, Shekerdemian LS (2003) Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med 29:1996–2003
  40. Hermon MM, Burda G, Golej J, Boigner H, Stoll E, Kitzmuller E, Wollenek G, Pollak A, Trittenwein G (2003) Methemoglobin formation in children with congenital heart disease treated with inhaled nitric oxide after cardiac surgery. Intensive Care Med 29:447–452
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  41. Dittrich S, Germanakis J, Dahnert I, Stiller B, Dittrich H, Vogel M, Lange PE (2003) Randomised trial on the influence of continuous magnesium infusion on arrhythmias following cardiopulmonary bypass surgery for congenital heart disease. Intensive Care Med 29:1141–1144
  42. Wald M, Kirchner L, Lawrenz K, Amann G (2003) Fatal air embolism in an extremely low birth weight infant: can it be caused by intravenous injections during resuscitation? Intensive Care Med 29:630–633
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  43. Matturri L, Ottaviani G, Rossi L (2003) Cardiac massage in infants. Intensive Care Med 29:1199–1200
  44. Schroth M, Jungert J, Schreiber M, Gerber-Zupan G, Zink S, Rascher W (2003) Life-threatening snakebites by Vipera berus. Intensive Care Med 29:1615
  45. Thiagarajan RR, Roth SJ, Margossian S, Mackie AS, Neufeld EJ, Laussen PC, Forbess JM, Blume ED (2003) Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A. Intensive Care Med 29:985–988
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  46. Courtman SP, Wardurgh A, Petros AJ (2003) Comparison of the Bispectral Index Monitor with the Comfort score in assessing level of sedation of critically ill children. Intensive Care Med 29:2239–2246
  47. Bouwmeester NJ, Hop WC, van Dijk M, Anand KJ, van den Anker JN, Tibboel D (2003) Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism. Intensive Care Med 29:2009–2015
  48. Bindl L, Buderus S, Dahlem P, Demirakca S, Goldner M, Huth R, Kohl M, Krause M, Kuhl P, Lasch P, Lewandowski K, Merz U, Moeller J, Mohamad Y, Peters M, Porz W, Vierzig A, Ruchard J, Scharf J, Varnholt V (2003) Gender-based differences in children with sepsis and ARDS: the ESPNIC ARDS Database Group. Intensive Care Med 29:1770–1773
  49. Leclerc F, Walter-Nicolet E, Leteurtre S, Noizet O, Sadik A, Cremer R, Fourier C (2003) Admission plasma vasopressin levels in children with meningococcal septic shock. Intensive Care Med 29:1339–1344
  50. Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ (2003) Cytochrome P450-mediated drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Med 29:980–984
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  51. Hatherill M, Waggie Z, Purves L, Reynolds L, Argent A (2003) Mortality and the nature of metabolic acidosis in children with shock. Intensive Care Med 29:286–291
  52. Chiaretti A, Piastra M, Polidori G, Di Rocco C, Caresta E, Antonelli A, Amendola T, Aloe L (2003) Correlation between neurotrophic factor expression and outcome of children with severe traumatic brain injury. Intensive Care Med 29:1329–1338
  53. Hoehn T, Preston AA, McPhaden AR, Stiller B, Vogel M, Buhrer C, Wadsworth RM (2003) Endothelial nitric oxide synthase (NOS) is upregulated in rapid progressive pulmonary hypertension of the newborn. Intensive Care Med 29:1757–1762
  54. Watremez C, Roeseler J, De Kock M, Clerbaux T, Detry B, Veriter C, Reynaert M, Gianello P, Jolliet P, Liistro G (2003) An improved porcine model of stable methacholine-induced bronchospasm. Intensive Care Med 29:119–125
  55. Calzia E, Radermacher P (2003) Alveolar ventilation and pulmonary blood flow: the V(A)/Q concept. Intensive Care Med 29:1229–1232
  56. Capdevila X, Lopez S, Bernard N, Rabischong E, Ramonatxo M, Martinazzo G, Prefaut C (2003) Effects of controlled mechanical ventilation on respiratory muscle contractile properties in rabbits. Intensive Care Med 29:103–110
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  57. Bernard N, Matecki S, Py G, Lopez S, Mercier J, Capdevila X (2003) Effects of prolonged mechanical ventilation on respiratory muscle ultrastructure and mitochondrial respiration in rabbits. Intensive Care Med 29:111–118
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  58. Hering R, Viehofer A, Berg A, Kreyer S, Zinserling J, Wrigge H, Putensen C (2003) Weight loss of respiratory muscles during mechanical ventilation. Intensive Care Med 29:1612
  59. Gayan-Ramirez G, de Paepe K, Cadot P, Decramer M (2003) Detrimental effects of short-term mechanical ventilation on diaphragm function and IGF-I mRNA in rats. Intensive Care Med 29:825–833
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  60. Caruso P, Meireles SI, Reis LF, Mauad T, Martins MA, Deheinzelin D (2003) Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of rats. Intensive Care Med 29:1808–1811
  61. Herrera MT, Toledo C, Valladares F, Muros M, Diaz-Flores L, Flores C, Villar J (2003) Positive end-expiratory pressure modulates local and systemic inflammatory responses in a sepsis-induced lung injury model. Intensive Care Med 29:1345–1353
  62. Luecke T, Roth H, Herrmann P, Joachim A, Weisser G, Pelosi P, Quintel M (2003) PEEP decreases atelectasis and extravascular lung water but not lung tissue volume in surfactant-washout lung injury. Intensive Care Med 29:2026–2033
  63. Vreugdenhil HA, Haitsma JJ, Jansen KJ, Zijlstra J, Plotz FB, Van Dijk JE, Lachmann B, Van Vught H, Heijnen CJ (2003) Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation. Intensive Care Med 29:915–922
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  64. Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA (2003) Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med 29:2034–2042
  65. Hubloue I, Biarent D, Abdel Kafi S, Bejjani G, Melot C, Naeije R, Leeman M (2003) Endothelin receptor blockade in canine oleic acid-induced lung injury. Intensive Care Med 29:1003–1006
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  66. Stubbe HD, Westphal M, Van Aken H, Hucklenbruch C, Lauer S, Jahn UR, Hinder F (2003) Inhaled nitric oxide reduces lung edema during fluid resuscitation in ovine acute lung injury. Intensive Care Med 29:1790–1797
  67. Rossi P, Oldner A, Wanecek M, Leksell LG, Rudehill A, Konrad D, Weitzberg E (2003) Comparison of gravimetric and a double-indicator dilution technique for assessment of extra-vascular lung water in endotoxaemia. Intensive Care Med 29:460–466
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  68. Lim CM, Kim MS, Ahn JJ, Kim MJ, Kwon Y, Lee I, Koh Y, Kim DS, Kim WD (2003) Hypothermia protects against endotoxin-induced acute lung injury in rats. Intensive Care Med 29:453–459
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  69. Tariq M, Moutaery AA, Arshaduddin M, Khan HA, Evans DP, Jacobs S (2003) Fluconazole attenuates lung injury and mortality in a rat peritonitis model. Intensive Care Med 29:2043–2049
  70. Loer SA, Schwarte LA, Pakulla MA, Picker O, Scheeren TW (2003) Partial liquid ventilation: effects of positive end-expiratory pressure on perfluorocarbon evaporation from the lungs of anesthetized dogs. Intensive Care Med 29:467–470
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  71. Cox PN, Frndova H, Karlsson O, Holowka S, Bryan CA (2003) Fluorocarbons facilitate lung recruitment. Intensive Care Med 29:2297–2302
  72. Klaus S, Heringlake M, Block K, Nolde J, Staubach K, Bahlmann L (2003) Metabolic changes detected by microdialysis during endotoxin shock and after endotoxin preconditioning. Intensive Care Med 29:634–641
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  73. Tenhunen JJ (2003) Lipopolysaccharide preconditioning attenuates metabolic alteration induced by endotoxin shock: tissue-specific monitoring by microdialysis. Intensive Care Med 29:515–517
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  74. Knuesel R, Jakob SM, Brander L, Bracht H, Siegenthaler A, Takala J (2003) Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction. Intensive Care Med 29:2255–2265
  75. De Backer D, Creteur J (2003) Regional hypoxia and partial pressure of carbon dioxide gradients: what is the link? Intensive Care Med 29:2116–2118
  76. Levy B, Mansart A, Bollaert PE, Franck P, Mallie JP (2003) Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism and organ energetics in endotoxemic rats. Intensive Care Med 29:292–300
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  77. Trager K, Radermacher P, Leverve X (2003) The adrenergic coin: perfusion and metabolism. Intensive Care Med 29:150–153
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  78. Scharte M, Nofer JR, Van Aken H, Waurick R, Meyer J, Bone HG (2003) Nicotinamide increases systemic vascular resistance in ovine endotoxemia. Intensive Care Med 29:989–994
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  79. Stehr A, Ploner F, Tugtekin I, Matejovic M, Theisen M, Zulke C, Georgieff M, Radermacher P, Jauch KW (2003) Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia. Intensive Care Med 29:995–1002
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  80. Pittner A, Nalos M, Asfar P, Yang Y, Ince C, Georgieff M, Bruckner UB, Radermacher P, Froba G (2003) Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. Intensive Care Med 29:312–316
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  81. Asfar P (2003) Terlipressin in chronic hyperdynamic endotoxic shock: is it safe? Intensive Care Med 29:154–155
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  82. Takahashi T, Matsuda K, Kono T, Pappas TN (2003) Inhibitory effects of hyperglycemia on neural activity of the vagus in rats. Intensive Care Med 29:309–311
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  83. Osowska S, De Bandt JP, Chaib S, Neveux N, Berard MP, Cynober L (2003) Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation. Intensive Care Med 29:1798–1801
  84. Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F (2003) Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med 29:1782–1789
  85. Albuszies G, Bruckner UB (2003) Antioxidant therapy in sepsis. Intensive Care Med 29:1632–1636
  86. Mohler J, Azoulay-Dupuis E, Amory-Rivier C, Mazoit JX, Bedos JP, Rieux V, Moine P (2003) Streptococcus pneumoniae strain-dependent lung inflammatory responses in a murine model of pneumococcal pneumonia. Intensive Care Med 29:808–816
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  87. Uchiyama T, Delude RL, Fink MP (2003) Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med 29:2050–2058
  88. Senftleben U (2003) NF-kappaB in critical diseases: a bad guy? Intensive Care Med 29:1873–1876
  89. Ohnesorge H, Bischoff P, Scholz J, Yekebas E, Schulte am Esch J (2003) Somatosensory evoked potentials as predictor of systemic inflammatory response syndrome in pigs? Intensive Care Med 29:801–807
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  90. Schraag S (2003) Studying septic encephalopathy: what animal models can predict. Intensive Care Med 29:667–668
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  91. Zwiener U, Walter B, Kratzsch B, Bauer R (2003) Marked reduction of brainstem blood flow in artificially ventilated newborn piglets during normoxia and normocapnic hypoxia. Intensive Care Med 29:2277–2284
  92. Myburgh JA, Upton RN, Grant C, Martinez A (2003) The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under propofol anaesthesia in an ovine model. Intensive Care Med 29:817–824
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  93. Kuo JR, Lin CL, Chio CC, Wang JJ, Lin MT (2003) Effects of hypertonic (3%) saline in rats with circulatory shock and cerebral ischemia after heatstroke. Intensive Care Med 29:1567–1573
  94. Behrends M, Peters J (2003) The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Intensive Care Med 29:1802–1807
  95. Kisch-Wedel H, Kemming G, Meisner F, Flondor M, Kuebler WM, Bruhn S, Koehler C, Zwissler B (2003) The prostaglandins epoprostenol and iloprost increase left ventricular contractility in vivo. Intensive Care Med 29:1574–1583
  96. Ricksten SE (2003) Is prostacyclin an inodilator? Intensive Care Med 29:1403–1405
  97. Abroug F, Nouira S, El Atrous S, Besbes L, Boukef R, Boussarsar M, Marghli S, Eurin J, Barthelemy C, El Ayeb M, Dellagi K, Carayon A (2003) A canine study of immunotherapy in scorpion envenomation. Intensive Care Med 29:2266–2276

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