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Critical synopsis and key questions in brain death determination

Eelco F. M. Wijdicks
Online First ™ - February , 2019

Pages 1 - 4

No abstract available.


  1. Wijdicks EF (2003) The neurologist and Harvard criteria for brain death. Neurology 61:970–976
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  2. Wijdicks EF, Varelas PN, Gronseth GS, Greer DM, American Academy of N (2010) Evidence-based guideline update: determining brain death in adults: report of the quality standards subcommittee of the American Academy of Neurology. Neurology 74:1911–1918
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  3. Webster PA, Markham LE (2018) Never declared brain dead potential organ donors—an additional source of donor organs? Prog Transpl 28:43–48
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  4. Tawil I, Brown LH, Comfort D et al (2014) Family presence during brain death evaluation: a randomized controlled trial. Crit Care Med 42:934–942
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  5. Daneshmand A, Rabinstein AA, Wijdicks EFM (2019) The apnea test in brain death determination using oxygen diffusion method remains safe. Neurology. https://doi.org/10.1212/WNL.0000000000006963
  6. Bronchard R, Durand L, Legeai C, Cohen J, Guerrini P, Bastien O (2017) Brain-dead donors on extracorporeal membrane oxygenation. Crit Care Med 45:1734–1741
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  7. Sandroni C, D’Arrigo S, Callaway CW et al (2016) The rate of brain death and organ donation in patients resuscitated from cardiac arrest: a systematic review and meta-analysis. Intensive Care Med 42:1661–1671
  8. Kentish-Barnes N, Cohen-Solal Z, Souppart V et al (2019) Being convinced and taking responsibility: a qualitative study of family members’ experience of organ donation decision and bereavement after brain death. Crit Care Med. https://doi.org/10.1097/CCM.0000000000003616
  9. Wahlster S, Wijdicks EF, Patel PV et al (2015) Brain death declaration: practices and perceptions worldwide. Neurology 84:1870–1879
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  10. Kramer AH (2015) Ancillary testing in brain death. Semin Neurol 35:125–138
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  11. Wijdicks EFM (2018) Deliberating death in the summer of 1968. N Engl J Med 379:412–415
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  12. Smith M, Citerio G (2017) Death determined by neurological criteria: the next steps. Intensive Care Med 43:1383–1385

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