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Lactate kinetics in critically ill: a new prognostic marker or just another brick in the wall?

Guillaume Geri| Glenn Hernandez| Antoine Vieillard-Baron
Volume 45, Issue 1 / January , 2019

Pages 113 - 114

No abstract available.


  1. Masyuk M, Wernly B, Lichtenauer M, Franz M, Kabich B, Muessig JM, Zimmermann G, Lauten A, Schulze C, Hoppe UC, Kelm M, Bakker J, Jung C (2018) Prognostic relevance of serum lactate kinetics in critically ill patients. Intensive Care Med. https://doi.org/10.1007/s00134-018-5475-3
  2. Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304377
  3. Hernandez G, Bellomo R, Bakker J (2018) The ten pitfalls of lactate clearance in sepsis. Intensive Care Med. https://doi.org/10.1007/s00134-018-5213-x
  4. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA, Emergency Medicine Shock Research Network (EMShockNet) Investigators (2010) Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 303:739–746
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  5. Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemnsen SP, Bakker J, LACTATE study group (2010) Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 182:752–761
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  6. Vincent JL, Quintairos EA, Couto L, Taccone FS (2016) The value of blood lactate kinetics in critically ill patients: a systematic review. Crit Care 20:257
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  7. Cnaan A, Laird NM, Slasor P (1997) Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med 16:2349–2380
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