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The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation

Samir Jaber| Giacomo Bellani| Lluis Blanch| Alexandre Demoule| Andrés Esteban| Luciano Gattinoni| Claude Guérin| Nicholas Hill| John G. Laffey| Salvatore Maurizio Maggiore| Jordi Mancebo| Paul H. Mayo| Jarrod M. Mosier| Paolo Navalesi| Michael Quintel| Jean Louis Vincent| John J. Marini
Research Agenda
Volume 43, Issue 9 / September , 2017

Pages 1352 - 1365

Abstract

In an important sense, support of the respiratory system has been a defining characteristic of intensive care since its inception. The pace of basic and clinical research in this field has escalated over the past two decades, resulting in palpable improvement at the bedside as measured by both efficacy and outcome. As in all medical research, however, novel ideas built upon observations are continually proposed, tested, and either retained or discarded on the basis of the persuasiveness of the evidence. What follows are concise descriptions of the current standards of management practice in respiratory support, the areas of present-day uncertainty, and our suggested agenda for the near future of research aimed at testing current assumptions, probing uncertainties, and solidifying the foundation on which to base our progress to the next level.

Keywords

References

  1. Quintel M, Tonetti T, Gattinoni L (2017) Will all ARDS patients be receiving mechanical ventilation in 2035? We are not sure. Intensive Care Med 43:573–574
  2. Mosier JM, Joshi R, Hypes C, Pacheco G, Valenzuela T, Sakles JC (2015) The physiologically difficult airway. West J Emerg Med 16:1109–1117
    • View reference on publisher's website
    • View reference on PubMed
  3. Hypes C, Sakles J, Joshi R, Greenberg J, Natt B, Malo J, Bloom J, Chopra H, Mosier J (2016) Failure to achieve first attempt success at intubation using video laryngoscopy is associated with increased complications. Intern Emerg Med. doi:10.1007/s11739-016-1549-9
  4. Perbet S, De Jong A, Delmas J, Futier E, Pereira B, Jaber S, Constantin JM (2015) Incidence of and risk factors for severe cardiovascular collapse after endotracheal intubation in the ICU: a multicenter observational study. Crit Care 19:257
    • View reference on publisher's website
    • View reference on PubMed
  5. Mosier JM, Hypes CD, Sakles JC (2016) Understanding preoxygenation and apneic oxygenation during intubation in the critically ill. Intensive Care Med 43(2):226–228
  6. Baillard C, Fosse JP, Sebbane M, Chanques G, Vincent F, Courouble P, Cohen Y, Eledjam JJ, Adnet F, Jaber S (2006) Noninvasive ventilation improves preoxygenation before intubation of hypoxic patients. Am J Respir Crit Care Med 174:171–177
    • View reference on publisher's website
    • View reference on PubMed
  7. Miguel-Montanes R, Hajage D, Messika J, Bertrand F, Gaudry S, Rafat C, Labbe V, Dufour N, Jean-Baptiste S, Bedet A, Dreyfuss D, Ricard JD (2015) Use of high-flow nasal cannula oxygen therapy to prevent desaturation during tracheal intubation of intensive care patients with mild-to-moderate hypoxemia. Crit Care Med 43:574–583
    • View reference on publisher's website
    • View reference on PubMed
  8. Vourc’h M, Asfar P, Volteau C, Bachoumas K, Clavieras N, Egreteau PY, Asehnoune K, Mercat A, Reignier J, Jaber S, Prat G, Roquilly A, Brule N, Villers D, Bretonniere C, Guitton C (2015) High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med 41(9):1538–1548
  9. Papazian L, Corley A, Hess D, Fraser JF, Frat JP, Guitton C, Jaber S, Maggiore SM, Nava S, Rello J, Ricard JD, Stephan F, Trisolini R, Azoulay E (2016) Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review. Intensive Care Med 42:1336–1349
  10. Koenig SJ, Lakticova V, Mayo PH (2011) Utility of ultrasonography for detection of gastric fluid during urgent endotracheal intubation. Intensive Care Med 37:627–631
  11. Jaber S, Jung B, Corne P, Sebbane M, Muller L, Chanques G, Verzilli D, Jonquet O, Eledjam JJ, Lefrant JY (2010) An intervention to decrease complications related to endotracheal intubation in the intensive care unit: a prospective, multiple-center study. Intensive Care Med 36:248–255
  12. Koenig SJ, Lakticova V, Narasimhan M, Doelken P, Mayo PH (2015) Safety of propofol as an induction agent for urgent endotracheal intubation in the medical intensive care unit. J Intensive Care Med 30:499–504
    • View reference on publisher's website
    • View reference on PubMed
  13. Mosier JM, Sakles JC, Stolz U, Hypes CD, Chopra H, Malo J, Bloom JW (2015) Neuromuscular blockade improves first-attempt success for intubation in the intensive care unit. A propensity matched analysis. Ann Am Thorac Soc 12:734–741
    • View reference on publisher's website
    • View reference on PubMed
  14. Jaber S, Monnin M, Girard M, Conseil M, Cisse M, Carr J, Mahul M, Delay JM, Belafia F, Chanques G, Molinari N, De Jong A (2016) Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial. Intensive Care Med 42:1877–1887
  15. De Jong A, Molinari N, Conseil M, Coisel Y, Pouzeratte Y, Belafia F, Jung B, Chanques G, Jaber S (2014) Video laryngoscopy versus direct laryngoscopy for orotracheal intubation in the intensive care unit: a systematic review and meta-analysis. Intensive Care Med 40:629–639
    • View reference on PubMed
  16. De Jong A, Molinari N, Conseil M, Coisel Y, Pouzeratte Y, Belafia F, Jung B, Chanques G, Jaber S (2014) Video laryngoscopy versus direct laryngoscopy for orotracheal intubation in the intensive care unit: a systematic review and meta-analysis. Intensive Care Med 40(5):629–639
    • View reference on PubMed
  17. Hypes CD, Stolz U, Sakles JC, Joshi RR, Natt B, Malo J, Bloom JW, Mosier JM (2016) Video laryngoscopy improves odds of first-attempt success at intubation in the intensive care unit. A propensity-matched analysis. Ann Am Thorac Soc 13:382–390
    • View reference on publisher's website
    • View reference on PubMed
  18. Lascarrou JB, Boisrame-Helms J, Bailly A, Le Thuaut A, Kamel T, Mercier E, Ricard JD, Lemiale V, Colin G, Mira JP, Meziani F, Messika J, Dequin PF, Boulain T, Azoulay E, Champigneulle B, Reignier J (2017) Video laryngoscopy vs direct laryngoscopy on successful first-pass orotracheal intubation among ICU patients: A randomized clinical trial. JAMA 317(5):483–493
    • View reference on publisher's website
    • View reference on PubMed
  19. De Jong A, Jung B, Daurat A, Chanques G, Mahul M, Monnin M, Molinari N, Jaber S (2016) Effect of rapid response systems on hospital mortality: a systematic review and meta-analysis. Intensive Care Med 42:615–617
  20. Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Jaber S (2016) Rapid response team and hospital mortality in hospitalized patients. Intensive Care Med 42:494–504
  21. Girou E, Schortgen F, Delclaux C, Brun-Buisson C, Blot F, Lefort Y, Lemaire F, Brochard L (2000) Association of noninvasive ventilation with nosocomial infections and survival in critically ill patients. JAMA 284:2361–2367
    • View reference on publisher's website
    • View reference on PubMed
  22. Mehta S, Hill NS (2001) Noninvasive ventilation. Am J Respir Crit Care Med 163:540–577
    • View reference on publisher's website
    • View reference on PubMed
  23. Kwok H, McCormack J, Cece R, Houtchens J, Hill NS (2003) Controlled trial of oronasal versus nasal mask ventilation in the treatment of acute respiratory failure. Crit Care Med 31:468–473
    • View reference on publisher's website
    • View reference on PubMed
  24. Nava S, Navalesi P, Gregoretti C (2009) Interfaces and humidification for noninvasive mechanical ventilation. Respir Care 54:71–84
    • View reference on PubMed
  25. Nava S, Navalesi P, Conti G (2006) Time of non-invasive ventilation. Intensive Care Med 32:361–370
  26. Lightowler JV, Wedzicha JA, Elliott MW, Ram FS (2003) Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis. BMJ 326:185
    • View reference on publisher's website
    • View reference on PubMed
  27. Vital FM, Ladeira MT, Atallah AN (2013) Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema. Cochrane Database Syst Rev 5:CD005351
  28. Lin C, Yu H, Fan H, Li Z (2014) The efficacy of noninvasive ventilation in managing postextubation respiratory failure: a meta-analysis. Heart Lung 43:99–104
    • View reference on publisher's website
    • View reference on PubMed
  29. Burns KE, Meade MO, Premji A, Adhikari NK (2014) Noninvasive ventilation as a weaning strategy for mechanical ventilation in adults with respiratory failure: a Cochrane systematic review. CMAJ 186:E112–E122
    • View reference on publisher's website
    • View reference on PubMed
  30. Hernandez G, Vaquero C, Colinas L, Cuena R, Gonzalez P, Canabal A, Sanchez S, Rodriguez ML, Villasclaras A, Fernandez R (2016) Effect of postextubation high-flow nasal cannula vs noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients: a randomized clinical trial. JAMA 316:1565–1574
    • View reference on publisher's website
    • View reference on PubMed
  31. Jaber S, Lescot T, Futier E, Paugam-Burtz C, Seguin P, Ferrandiere M, Lasocki S, Mimoz O, Hengy B, Sannini A, Pottecher J, Abback PS, Riu B, Belafia F, Constantin JM, Masseret E, Beaussier M, Verzilli D, De Jong A, Chanques G, Brochard L, Molinari N (2016) Effect of noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: a randomized clinical trial. JAMA 315:1345–1353
    • View reference on publisher's website
    • View reference on PubMed
  32. Hernandez G, Fernandez R, Lopez-Reina P, Cuena R, Pedrosa A, Ortiz R, Hiradier P (2010) Noninvasive ventilation reduces intubation in chest trauma-related hypoxemia: a randomized clinical trial. Chest 137:74–80
    • View reference on publisher's website
    • View reference on PubMed
  33. Demoule A, Hill N, Navalesi P (2016) Can we prevent intubation in patients with ARDS? Intensive Care Med 42:768–771
  34. Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, Esteban A, Gattinoni L, Bumbasirevic V, Piquilloud L, van Haren F, Larsson A, McAuley DF, Bauer PR, Arabi YM, Ranieri M, Antonelli M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A (2017) Noninvasive ventilation of patients with acute respiratory distress syndrome. Insights from the LUNG SAFE study. Am J Respir Crit Care Med 195:67–77
    • View reference on publisher's website
    • View reference on PubMed
  35. Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308
  36. Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, Stewart TE, Briel M, Talmor D, Mercat A, Richard JC, Carvalho CR, Brower RG (2015) Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med 372:747–755
    • View reference on publisher's website
    • View reference on PubMed
  37. Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A (2016) Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med 42:1865–1876
  38. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315:788–800
    • View reference on publisher's website
    • View reference on PubMed
  39. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351:327–336
    • View reference on publisher's website
    • View reference on PubMed
  40. Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L (2008) Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299:646–655
    • View reference on publisher's website
    • View reference on PubMed
  41. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE (2008) Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299:637–645
    • View reference on publisher's website
    • View reference on PubMed
  42. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, Brochard L, Richard JC, Lamontagne F, Bhatnagar N, Stewart TE, Guyatt G (2010) Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA 303:865–873
    • View reference on publisher's website
    • View reference on PubMed
  43. Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Slutsky AS, Vincent JL, Rubenfeld GD, Thompson BT, Ranieri VM (2012) The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 38:1573–1582
  44. Goligher EC, Kavanagh BP, Rubenfeld GD, Adhikari NK, Pinto R, Fan E, Brochard LJ, Granton JT, Mercat A, Marie Richard JC, Chretien JM, Jones GL, Cook DJ, Stewart TE, Slutsky AS, Meade MO, Ferguson ND (2014) Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials. Am J Respir Crit Care Med 190:70–76
    • View reference on publisher's website
    • View reference on PubMed
  45. Fan E, Wilcox ME, Brower RG, Stewart TE, Mehta S, Lapinsky SE, Meade MO, Ferguson ND (2008) Recruitment maneuvers for acute lung injury: a systematic review. Am J Respir Crit Care Med 178:1156–1163
    • View reference on publisher's website
    • View reference on PubMed
  46. Chacko B, Peter JV, Tharyan P, John G, Jeyaseelan L (2015) Pressure-controlled versus volume-controlled ventilation for acute respiratory failure due to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Cochrane Database Syst Rev 1:008807
  47. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO (2013) High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 368:795–805
    • View reference on publisher's website
    • View reference on PubMed
  48. Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH (2013) High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 368:806–813
    • View reference on publisher's website
    • View reference on PubMed
  49. Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368:2159–2168
    • View reference on publisher's website
    • View reference on PubMed
  50. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guerin C, Prat G, Morange S, Roch A (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363:1107–1116
    • View reference on publisher's website
    • View reference on PubMed
  51. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T (2007) Weaning from mechanical ventilation. Eur Respir J 29:1033–1056
    • View reference on publisher's website
    • View reference on PubMed
  52. Beduneau G, Pham T, Schortgen F, Piquilloud L, Zogheib E, Jonas M, Grelon F, Runge I, Terzi N, Grange S, Barberet G, Guitard PG, Frat JP, Constan A, Chretien JM, Mancebo J, Mercat A, Richard JM, Brochard L (2016) Epidemiology of weaning outcome according to a new definition. The WIND study. Am J Respir Crit Care Med 195(6):772–783
    • View reference on publisher's website
  53. Ouellette DR, Patel S, Girard TD, Morris PE, Schmidt GA, Truwit JD, Al-Hazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong M, Hough CL, Mehta S, Nanchal R, Pawlik AJ, Schweickert W, Sessler CN, Strom T, Kress JP (2017) Liberation from mechanical ventilation: an official American College of Chest Physicians/American Thoracic Society clinical practice guideline: inspiratory pressure augmentation during spontaneous breathing trials, protocols minimizing sedation, and non-invasive ventilation immediately after extubation. Chest 151:166–180
  54. Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Beduneau G, Deletage-Metreau C, Richard JC, Brochard L, Robert R (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196
    • View reference on publisher's website
    • View reference on PubMed
  55. Patel BK, Wolfe KS, Pohlman AS, Hall JB, Kress JP (2016) Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial. JAMA 315:2435–2441
    • View reference on publisher's website
    • View reference on PubMed
  56. Lemiale V, Resche-Rigon M, Mokart D, Pene F, Argaud L, Mayaux J, Guitton C, Rabbat A, Girault C, Kouatchet A, Vincent F, Bruneel F, Nyunga M, Seguin A, Klouche K, Colin G, Kontar L, Perez P, Meert AP, Benoit DD, Papazian L, Demoule A, Chevret S, Azoulay E (2016) High-flow nasal cannula oxygenation in immunocompromised patients with acute hypoxemic respiratory failure: a Groupe de Recherche Respiratoire en Reanimation Onco-Hematologique study. Crit Care Med 45(3):e274–e280
    • View reference on publisher's website
  57. Lemiale V, Mokart D, Resche-Rigon M, Pene F, Mayaux J, Faucher E, Nyunga M, Girault C, Perez P, Guitton C, Ekpe K, Kouatchet A, Theodose I, Benoit D, Canet E, Barbier F, Rabbat A, Bruneel F, Vincent F, Klouche K, Loay K, Mariotte E, Bouadma L, Moreau AS, Seguin A, Meert AP, Reignier J, Papazian L, Mehzari I, Cohen Y, Schenck M, Hamidfar R, Darmon M, Demoule A, Chevret S, Azoulay E (2015) Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial. JAMA 314:1711–1719
    • View reference on publisher's website
    • View reference on PubMed
  58. Coudroy R, Jamet A, Petua P, Robert R, Frat JP, Thille AW (2016) High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study. Ann Intensive Care 6:45
    • View reference on publisher's website
    • View reference on PubMed
  59. Hernandez G, Vaquero C, Gonzalez P, Subira C, Frutos-Vivar F, Rialp G, Laborda C, Colinas L, Cuena R, Fernandez R (2016) Effect of postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients: a randomized clinical trial. JAMA 315:1354–1361
    • View reference on publisher's website
    • View reference on PubMed
  60. Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M (2016) Ventilator-related causes of lung injury: the mechanical power. Intensive Care Med 42:1567–1575
  61. Yoshida T, Fujino Y, Amato MB, Kavanagh BP (2017) Spontaneous breathing during mechanical ventilation—risks, mechanisms and management. Am J Respir Crit Care Med 195(8):985–992
  62. Georgopoulos D, Xirouchaki N, Tzanakis N, Younes M (2016) Driving pressure during assisted mechanical ventilation: is it controlled by patient brain? Respir Physiol Neurobiol 228:69–75
    • View reference on publisher's website
    • View reference on PubMed
  63. Blanch L, Villagra A, Sales B, Montanya J, Lucangelo U, Lujan M, Garcia-Esquirol O, Chacon E, Estruga A, Oliva JC, Hernandez-Abadia A, Albaiceta GM, Fernandez-Mondejar E, Fernandez R, Lopez-Aguilar J, Villar J, Murias G, Kacmarek RM (2015) Asynchronies during mechanical ventilation are associated with mortality. Intensive Care Med 41:633–641
  64. Vaporidi K, Babalis D, Chytas A, Lilitsis E, Kondili E, Amargianitakis V, Chouvarda I, Maglaveras N, Georgopoulos D (2016) Clusters of ineffective efforts during mechanical ventilation: impact on outcome. Intensive Care Med 43(2):184–191
  65. Conti G, Ranieri VM, Costa R, Garratt C, Wighton A, Spinazzola G, Urbino R, Mascia L, Ferrone G, Pohjanjousi P, Ferreyra G, Antonelli M (2016) Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study. Crit Care 20:206
    • View reference on publisher's website
    • View reference on PubMed
  66. Celli BR, MacNee W, Force AET (2004) Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 23:932–946
    • View reference on publisher's website
    • View reference on PubMed
  67. Alia I, de la Cal MA, Esteban A, Abella A, Ferrer R, Molina FJ, Torres A, Gordo F, Elizalde JJ, de Pablo R, Huete A, Anzueto A (2011) Efficacy of corticosteroid therapy in patients with an acute exacerbation of chronic obstructive pulmonary disease receiving ventilatory support. Arch Intern Med 171:1939–1946
    • View reference on publisher's website
    • View reference on PubMed
  68. Abroug F, Ouanes-Besbes L, Fkih-Hassen M, Ouanes I, Ayed S, Dachraoui F, Brochard L, Elatrous S (2014) Prednisone in COPD exacerbation requiring ventilatory support: an open-label randomised evaluation. Eur Respir J 43:717–724
    • View reference on publisher's website
    • View reference on PubMed
  69. Abroug F, Ouanes I, Abroug S, Dachraoui F, Abdallah SB, Hammouda Z, Ouanes-Besbes L (2014) Systemic corticosteroids in acute exacerbation of COPD: a meta-analysis of controlled studies with emphasis on ICU patients. Ann Intensive Care 4:32
    • View reference on publisher's website
    • View reference on PubMed
  70. Demoule A, Chevret S, Carlucci A, Kouatchet A, Jaber S, Meziani F, Schmidt M, Schnell D, Clergue C, Aboab J, Rabbat A, Eon B, Guerin C, Georges H, Zuber B, Dellamonica J, Das V, Cousson J, Perez D, Brochard L, Azoulay E, oVNI Study Group; REVA Network (Research Network in Mechanical Ventilation) (2016) Changing use of noninvasive ventilation in critically ill patients: trends over 15 years in francophone countries. Intensive Care Med 42:82–92
  71. Hilbert G, Gruson D, Vargas F, Valentino R, Gbikpi-Benissan G, Dupon M, Reiffers J, Cardinaud JP (2001) Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 344:481–487
    • View reference on publisher's website
    • View reference on PubMed
  72. Antonelli M, Conti G, Bufi M, Costa MG, Lappa A, Rocco M, Gasparetto A, Meduri GU (2000) Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. JAMA 283:235–241
    • View reference on publisher's website
    • View reference on PubMed
  73. Froese AB (1997) High-frequency oscillatory ventilation for adult respiratory distress syndrome: let’s get it right this time! Crit Care Med 25:906–908
    • View reference on publisher's website
    • View reference on PubMed
  74. Derdak S, Mehta S, Stewart TE, Smith T, Rogers M, Buchman TG, Carlin B, Lowson S, Granton J, Multicenter Oscillatory Ventilation For Acute Respiratory Distress Syndrome Trial Study I (2002) High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial. Am J Respir Crit Care Med 166:801–808
    • View reference on publisher's website
    • View reference on PubMed
  75. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO, OSCILLATE Trial Investigators, Canadian Critical Care Trials Group (2013) High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 368:795–805
    • View reference on publisher's website
    • View reference on PubMed
  76. Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH, OSCAR Study Group (2013) High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 368:806–813
    • View reference on publisher's website
    • View reference on PubMed
  77. Freeman BD, Morris PE (2012) Tracheostomy practice in adults with acute respiratory failure. Crit Care Med 40:2890–2896
    • View reference on publisher's website
    • View reference on PubMed
  78. Simon M, Metschke M, Braune SA, Puschel K, Kluge S (2013) Death after percutaneous dilatational tracheostomy: a systematic review and analysis of risk factors. Crit Care 17:R258
    • View reference on publisher's website
    • View reference on PubMed
  79. Vargas M, Sutherasan Y, Antonelli M, Brunetti I, Corcione A, Laffey JG, Putensen C, Servillo G, Pelosi P (2015) Tracheostomy procedures in the intensive care unit: an international survey. Crit Care 19:291
    • View reference on publisher's website
    • View reference on PubMed
  80. Terragni PP, Antonelli M, Fumagalli R, Faggiano C, Berardino M, Pallavicini FB, Miletto A, Mangione S, Sinardi AU, Pastorelli M, Vivaldi N, Pasetto A, Della Rocca G, Urbino R, Filippini C, Pagano E, Evangelista A, Ciccone G, Mascia L, Ranieri VM (2010) Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial. JAMA 303:1483–1489
    • View reference on publisher's website
    • View reference on PubMed
  81. Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157:294–323
    • View reference on publisher's website
    • View reference on PubMed
  82. Engoren M, Arslanian-Engoren C, Fenn-Buderer N (2004) Hospital and long-term outcome after tracheostomy for respiratory failure. Chest 125:220–227
    • View reference on publisher's website
    • View reference on PubMed
  83. Slutsky AS, Ranieri VM (2013) Ventilator-induced lung injury. N Engl J Med 369:2126–2136
    • View reference on publisher's website
    • View reference on PubMed
  84. Bello G, De Pascale G, Antonelli M (2016) Noninvasive ventilation. Clin Chest Med 37:711–721
    • View reference on publisher's website
    • View reference on PubMed
  85. Esteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C, Gonzalez M, Epstein SK, Hill NS, Nava S, Soares MA, D’Empaire G, Alia I, Anzueto A (2004) Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med 350:2452–2460
    • View reference on publisher's website
    • View reference on PubMed
  86. Braune S, Sieweke A, Brettner F, Staudinger T, Joannidis M, Verbrugge S, Frings D, Nierhaus A, Wegscheider K, Kluge S (2016) The feasibility and safety of extracorporeal carbon dioxide removal to avoid intubation in patients with COPD unresponsive to noninvasive ventilation for acute hypercapnic respiratory failure (ECLAIR study): multicentre case-control study. Intensive Care Med 42:1437–1444
  87. Del Sorbo L, Pisani L, Filippini C, Fanelli V, Fasano L, Terragni P, Dell’Amore A, Urbino R, Mascia L, Evangelista A, Antro C, D’Amato R, Sucre MJ, Simonetti U, Persico P, Nava S, Ranieri VM (2015) Extracorporeal CO2 removal in hypercapnic patients at risk of noninvasive ventilation failure: a matched cohort study with historical control. Crit Care Med 43:120–127
    • View reference on publisher's website
    • View reference on PubMed
  88. Koestler A, Smythies JR (1969) Beyond reductionism: new perspectives in the life sciences. Hutchinson, London
  89. Berry D (2011) Adaptive clinical trials: the promise and the caution. J Clin Oncol 20:606–609
    • View reference on publisher's website
  90. Marini JJ, Vincent JL, Annane D (2015) Critical care evidence—new directions. JAMA 313:893–894
    • View reference on publisher's website
    • View reference on PubMed
  91. Yoshida T, Roldan R, Beraldo MA, Torsani V, Gomes S, De Santis RR, Costa EL, Tucci MR, Lima RG, Kavanagh BP, Amato MB (2016) Spontaneous effort during mechanical ventilation: maximal injury with less positive end-expiratory pressure. Crit Care Med 44:e678–e688
    • View reference on publisher's website
    • View reference on PubMed
  92. Cornejo RA, Diaz JC, Tobar EA, Bruhn AR, Ramos CA, Gonzalez RA, Repetto CA, Romero CM, Galvez LR, Llanos O, Arellano DH, Neira WR, Diaz GA, Zamorano AJ, Pereira GL (2013) Effects of prone positioning on lung protection in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 188:440–448
    • View reference on publisher's website
    • View reference on PubMed
  93. Guerin C, Moss M, Talmor D (2016) A glossary of ARDS for beginners. Intensive Care Med 42:659–662
  94. Marini JJ, Jaber S (2016) Dynamic predictors of VILI risk: beyond the driving pressure. Intensive Care Med 42:1597–1600
  95. Futier E, Constantin JM, Paugam-Burtz C, Pascal J, Eurin M, Neuschwander A, Marret E, Beaussier M, Gutton C, Lefrant JY, Allaouchiche B, Verzilli D, Leone M, De Jong A, Bazin JE, Pereira B, Jaber S (2013) A trial of intraoperative low-tidal-volume ventilation in abdominal surgery. N Engl J Med 369:428–437
    • View reference on publisher's website
    • View reference on PubMed
  96. Gattinoni L, Giomarelli P (2015) Acquiring knowledge in intensive care: merits and pitfalls of randomized controlled trials. Intensive Care Med 41:1460–1464
  97. Ghassemi M, Celi LA, Stone DJ (2015) State of the art review: the data revolution in critical care. Crit Care 19:118
    • View reference on publisher's website
    • View reference on PubMed
  98. Ahasic AM, Christiani DC (2015) Personalized critical care medicine: how far away are we? Semin Respir Crit Care Med 36:809–822
    • View reference on publisher's website
    • View reference on PubMed
  99. Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL (2017) The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med 43(2):171–183
  100. Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, Morelli A, Antonelli M, Singer M (2016) Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA 316:1583–1589
    • View reference on publisher's website
    • View reference on PubMed
  101. Marini JJ (2013) Too much for too long-wrong targets, wrong timing? Crit Care Med 41:664–665
    • View reference on publisher's website
    • View reference on PubMed
  102. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D (2016) Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med 42:1427–1436
  103. Talmor D, Sarge T, Malhotra A, O’Donnell CR, Ritz R, Lisbon A, Novack V, Loring SH (2008) Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med 359:2095–2104
    • View reference on publisher's website
    • View reference on PubMed
  104. Nelson JE, Cox CE, Hope AA, Carson SS (2010) Chronic critical illness. Am J Respir Crit Care Med 182:446–454
    • View reference on publisher's website
    • View reference on PubMed
  105. Kassis EB, Loring SH, Talmor D et al (2016) Is transpulmonary pressure-guided PEEP titration really optimal? Response to Yamaga. Intensive Care Med 42:1847–1848

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