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Cardiac dysfunction in sepsis

Anders Aneman| Antoine Vieillard-Baron
Understanding the Disease
Volume 42, Issue 12 / December , 2016

Pages 2073 - 2076

No abstract available.


  1. Vieillard-Baron A, Caille V, Charron C, Belliard G, Page B, Jardin F (2008) Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med 36:1701–1706
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  2. Teboul JL, Saugel B, Cecconi M, De Backer D, Hofer CK, Monnet X, Perel A, Pinsky, Reuter DA, Rhodes A, Squara P, Vincent JL, Scheeren TW (2016) Less invasive hemodynamic monitoring in critically ill patients. Intensive Care Med. doi:10.1007/s00134-016-4375-7
  3. Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, Jaeschke R, Mebazaa A, Pinsky MR, Teboul JL, Vincent JL, Rhodes A (2014) Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med 40:1795–1815
  4. Bull TM, Clark B, McFann K, Moss M, National Institutes of Health, National Heart, Lung, and Blood Institute ARDS Network (2010) Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury. Am J Repsir Crit Care Med 182:1123–1128
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  5. Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ (2016) Experts’ opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med 42:739–749
  6. Huang SJ, Nalos M, McLean AS (2013) Is early ventricular dysfunction or dilatation associated with lower mortality rate in adult severe sepsis and septic shock? A meta-analysis. Crit Care 17:R96. doi:10.1186/cc12741
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  7. Chang WT, Lee WH, Lee WT, Chen PS, Su YR, Liu PY, Liu YW, Tsai WC (2015) Left ventricular global longitudinal strain is independently associated with mortality in septic shock patients. Intensive Care Med 41:1791–1799
  8. Gonzalez C, Begot E, Dalmay F, Pichon N, François B, Fedou AL, Chapellas C, Galy A, Mancia C, Daix T, Vignon P (2016) Prognostic impact of left ventricular diastolic function in patients with septic shock. Ann Intensive Care 6:36. doi:10.1186/s13613-016-0136-6
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  9. Landesberg G, Gilon D, Meroz Y, Georgieva M, Levin PD, Goodman S et al (2012) Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J 33:895–903
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  10. Orde SR, Pulido JN, Masaki M, Gillespie S, Spoon JN, Kane GC, Oh JK (2014) Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function. Crit Care 18:R149. doi:10.1186/cc13987
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  11. Zangrillo A, Putzu A, Monaco F, Oriani A, Frau G, De Luca M, Di Tomasso N, Bignami E, Lomivorotov V, Likhvantsev V, Landoni G (2015) Levosimendan reduces mortality in patients with severe sepsis and septic shock: a meta-analysis of randomized trials. J Crit Care 30:908–913
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  12. Orme RM, Perkins GD, McAuley DF, Liu KD, Mason AJ, Morelli A, Singer M, Ashby D, Gordon AC (2014) An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. Trials 15:199. doi:10.1186/1745-6215-15-199
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  13. Vieillard Baron A, Schmitt JM, Beauchet A, Augarde R, Prin S, Page B, Jardin F (2001) Early preload adaptation in septic shock? A transesophageal echocardiographic study. Anesthesiology 94:400–406
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  14. Asfar P, Russell JA, Tuckermann J, Radermacher P (2016) Selepressin in septic shock: a step toward decatecholaminization? Crit Care Med 44:234–236
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  15. Morelli A, Singer M, Ranieri VM, D’Egidio A, Mascia L, Orecchioni A, Piscioneri F, Guarracino F, Greco E, Peruzzi M, Biondi-Zoccai G, Frati G, Romano SM (2016) Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study. Intensive Care Med. doi:10.1007/s00134-016-4351-2

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