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What’s new in skin antisepsis for short-term intravascular catheters: new data to address old problems?

Olivier Mimoz| Vineet Chopra| Andreas Widmer
What's New in Intensive Care
Volume 42, Issue 12 / December , 2016

Pages 2043 - 2045

No abstract available.


  1. Frasca D, Dahyot-Fizelier C, Mimoz O (2010) Prevention of central venous catheter-related infection in the intensive care unit. Crit Care 14:212
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  2. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S (2002) Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 136:792–801
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  3. Pages J, Hazera P, Mégarbane B, du Cheyron D, Thuong M, Dutheil JJ, Valette X, Fournel F, Mermel LA, Mira JP, Daubin C, Parienti JJ, 3SITES Study Group (2016) Comparison of alcoholic chlorhexidine and povidone-iodine cutaneous antiseptics for the prevention of central venous catheter-related infection: a cohort and quasi-experimental multicenter study. Intensive Care Med. doi:10.1007/s00134-016-4406-4
  4. Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF, CLEAN trial investigators (2015) Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial. Lancet 386:2069–2077
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  5. Mimoz O, Chopra V, Timsit JF (2016) What’s new in catheter-related infection: skin cleansing and skin antisepsis. Intensive Care Med. doi:10.1007/s00134-016-4244-4
  6. Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, Miller HJ, Awad SS, Crosby CT, Mosier MC, Alsharif A, Berger DH (2010) Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 362:18–26
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  7. Tuuli MG, Liu J, Stout MJ, Martin S, Cahill AG, Odibo AO, Colditz GA, Macones GA (2016) A randomized trial comparing skin antiseptic agents at cesarean delivery. N Engl J Med 374:647–655
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  8. Casey A, Itrakjy A, Birkett C, Clethro A, Bonser R, Graham T, Mascaro J, Pagano D, Rooney S, Wilson I, Nightingale P, Crosby C, Elliott T (2015) A comparison of the efficacy of 70 % v/v isopropyl alcohol with either 0.5 % w/v or 2 % w/v chlorhexidine gluconate for skin preparation before harvest of the long saphenous vein used in coronary artery bypass grafting. Am J Infect Control 43:816–820
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  9. Stewart BJ, Gardiner T, Perry GJ, Tong SY (2016) Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures. J Hosp Infect 92:191–193
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  10. McCann M, Fitzpatrick F, Mellotte G, Clarke M (2016) Is 2 % chlorhexidine gluconate in 70 % isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: a pilot multicenter randomized trial (ISRCTN2657745)? Am J Infect Control 44:948–949
  11. Warren DK, Prager M, Munigala S, Wallace MA, Kennedy CR, Bommarito KM, Mazuski JE, Burnham CA (2016) Prevalence of qacA/B genes and mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) isolates in the setting of chlorhexidine bathing without mupirocin. Infect Control Hosp Epidemiol 37:590–597
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  12. Dettenkofer M, Wilson C, Gratwohl A, Schmoor C, Bertz H, Frei R, Heim D, Luft D, Schulz S, Widmer AF (2010) Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial. Clin Microbiol Infect 16:600–606
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  13. Tietz A, Frei R, Dangel M, Bolliger D, Passweg JR, Gratwohl A, Widmer AE (2005) Octenidine hydrochloride for the care of central venous catheter insertion sites in severely immunocompromised patients. Infect Control Hosp Epidemiol 26:703–707
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  14. Bilir A, Yelken B, Erkan A (2013) Chlorhexidine, octenidine or povidone iodine for catheter related infections: a randomized controlled trial. J Res Med Sci 18:510–512
  15. Forni C, Sabattini T, D’Alessandro F, Fiorani A, Gamberini S, Maso A, Curci R, Zanotti E, Chiari P (2015) Use of sodium hypochlorite for skin antisepsis before inserting a peripheral venous catheter: a pilot study. Biol Res Nurs 17:330–333
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