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Blood glucose control in the ICU: don’t throw out the baby with the bathwater!

Jan Gunst| Greet Van den Berghe
What's New in Intensive Care
Volume 42, Issue 9 / September , 2016

Pages 1478 - 1481

No abstract available.

References

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  2. Gunst J, Van den Berghe G (2010) Blood glucose control in the intensive care unit: benefits and risks. Semin Dial 23:157–162. doi:10.1111/j.1525-139X.2010.00702.x
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  4. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354:449–461. doi:10.1056/NEJMoa052521
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  5. Vlasselaers D, Milants I, Desmet L, Wouters PJ, Vanhorebeek I, van den Heuvel I, Mesotten D, Casaer MP, Meyfroidt G, Ingels C, Muller J, Van Cromphaut S, Schetz M, Van den Berghe G (2009) Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet 373:547–556. doi:10.1016/S0140-6736(09)60044-1
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  7. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G (2011) Early versus late parenteral nutrition in critically ill adults. N Engl J Med 365:506–517. doi:10.1056/NEJMoa1102662
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  8. Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van den Berghe G (2013) Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med 187:247–255. doi:10.1164/rccm.201206-0999OC
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  9. Derde S, Vanhorebeek I, Güiza F, Derese I, Gunst J, Fahrenkrog B, Martinet W, Vervenne H, Ververs EJ, Larsson L, Van den Berghe G (2012) Early parenteral nutrition evokes a phenotype of autophagy deficiency in liver and skeletal muscle of critically ill rabbits. Endocrinology 153:2267–2276. doi:10.1210/en.2011-2068
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  10. Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, Herijgers P, Mathieu C, Van den Berghe G (2006) Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes 55:1096–1105. doi:10.2337/diabetes.55.04.06.db05-1434
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  11. Derde S, Vanhorebeek I, Ververs EJ, Vanhees I, Darras VM, Van Herck E, Larsson L, Van den Berghe G (2010) Increasing intravenous glucose load in the presence of normoglycemia: effect on outcome and metabolism in critically ill rabbits. Crit Care Med 38:602–611. doi:10.1097/CCM.0b013e3181c03f65
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  12. Sonneville R, den Hertog HM, Derde S, Güiza F, Derese I, Van den Berghe G, Vanhorebeek I (2013) Increasing glucose load while maintaining normoglycemia does not evoke neuronal damage in prolonged critically ill rabbits. Clin Nutr 32:1077–1080. doi:10.1016/j.clnu.2013.01.003
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  13. Vanhorebeek I, Ellger B, De Vos R, Boussemaere M, Debaveye Y, Vander Perre S, Rabbani N, Thornalley PJ, Van den Berghe G (2009) Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Crit Care Med 37:1355–1364. doi:10.1097/CCM.0b013e31819cec17
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  14. Vanhorebeek I, Gunst J, Ellger B, Boussemaere M, Lerut E, Debaveye Y, Rabbani N, Thornalley PJ, Schetz M, Van den Berghe G (2009) Hyperglycemic kidney damage in an animal model of prolonged critical illness. Kidney Int 76:512–520. doi:10.1038/ki.2009.217
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  15. Sonneville R, den Hertog HM, Guïza F, Gunst J, Derese I, Wouters PJ, Brouland JP, Polito A, Gray F, Chrétien F, Charlier P, Annane D,  Sharshar T, Van den Berghe G, Vanhorebeek I (2012) Impact of hyperglycemia on neuropathological alterations during critical illness. J Clin Endocrinol Metab 97:2113–2123. doi:10.1210/jc.2011-2971
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  16. Van Herpe T, Mesotten D, Wouters PJ, Herbots J, Voets E, Buyens J, De Moor B, Van den Berghe G (2013) LOGIC-insulin algorithm-guided versus nurse-directed blood glucose control during critical illness: the LOGIC-1 single-center, randomized, controlled clinical trial. Diabetes Care 36:188–194. doi:10.2337/dc12-0584
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  17. Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA (2007) Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. J Clin Invest 117:910–918. doi:10.1172/JCI30077
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  18. Mesotten D, Gielen M, Sterken C, Claessens K, Hermans G, Vlasselaers D, Lemiere J, Lagae L, Gewillig M, Eyskens B, Vanhorebeek I, Wouters PJ, Van den Berghe G (2012) Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control: a randomized controlled trial. JAMA 308:1641–1650. doi:10.1001/jama.2012.12424
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  19. Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, De Wolf-Peeters C, Van den Berghe G (2005) Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365:53–59. doi:10.1016/S0140-6736(04)17665-4
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  20. Langouche L, Vanhorebeek I, Vlasselaers D, Vander Perre S, Wouters PJ, Skogstrand K, Hansen TK, Van den Berghe G (2005) Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 115:2277–2286. doi:10.1172/JCI25385
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  21. Ellger B, Langouche L, Richir M, Debaveye Y, Vanhorebeek I, Teerlink T, Van Leeuwen PA, Van den Berghe G (2008) Modulation of regional nitric oxide metabolism: blood glucose control or insulin? Intensive Care Med 34:1525–1533. doi:10.1007/s00134-008-1118-4
  22. Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G (2004) Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89:219–226. doi:10.1210/jc.2003-030760
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  23. Vlasselaers D, Mesotten D, Langouche L, Vanhorebeek I, van den Heuvel I, Milants I, Wouters P, Wouters P, Meyns B, Bjerre M, Hansen TK, Van den Berghe G (2010) Tight glycemic control protects the myocardium and reduces inflammation in neonatal heart surgery. Ann Thorac Surg 90:22–29. doi:10.1016/j.athoracsur.2010.03.093
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  24. Weekers F, Giulietti AP, Michalaki M, Coopmans W, Van Herck E, Mathieu C, Van den Berghe G (2003) Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology 144:5329–5338. doi:10.1210/en.2003-0697
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  25. Ingels C, Moller HJ, Hansen TK, Wouters PJ, Vanhorebeek I, Van den Berghe G (2013) Circulating levels of the shed scavenger receptor sCD163 and association with outcome of critically ill patients. J Clin Immunol 33:619–629. doi:10.1007/s10875-012-9830-9
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  26. Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ (2005) Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64:1348–1353. doi:10.1212/01.WNL.0000158442.08857.FC
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  27. Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, Bruyninckx F, Van den Berghe G (2007) Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med 175:480–489. doi:10.1164/rccm.200605-665OC
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  28. Schetz M, Vanhorebeek I, Wouters PJ, Wilmer A, Van den Berghe G (2008) Tight blood glucose control is renoprotective in critically ill patients. J Am Soc Nephrol 19:571–578. doi:10.1681/ASN.2006101091
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  29. Mesotten D, Wauters J, Van den Berghe G, Wouters PJ, Milants I, Wilmer A (2009) The effect of strict blood glucose control on biliary sludge and cholestasis in critically ill patients. J Clin Endocrinol Metab 94:2345–2352. doi:10.1210/jc.2008-2579
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