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Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers

Margaret S. Herridge| Marc Moss| Catherine L. Hough| Ramona O. Hopkins| Todd W. Rice| O. Joseph Bienvenu| Elie Azoulay
Review
Volume 42, Issue 5 / May , 2016

Pages 725 - 738

Abstract

Outcomes after acute respiratory distress syndrome (ARDS) are similar to those of other survivors of critical illness and largely affect the nerve, muscle, and central nervous system but also include a constellation of varied physical devastations ranging from contractures and frozen joints to tooth loss and cosmesis. Compromised quality of life is related to a spectrum of impairment of physical, social, emotional, and neurocognitive function and to a much lesser extent discrete pulmonary disability. Intensive care unit-acquired weakness (ICUAW) is ubiquitous and includes contributions from both critical illness polyneuropathy and myopathy, and recovery from these lesions may be incomplete at 5 years after ICU discharge. Cognitive impairment in ARDS survivors ranges from 70 to 100 % at hospital discharge, 46 to 80 % at 1 year, and 20 % at 5 years, and mood disorders including depression and post-traumatic stress disorder (PTSD) are also sustained and prevalent. Robust multidisciplinary and longitudinal interventions that improve these outcomes are still uncertain and data in our literature are conflicting. Studies are needed in family members of ARDS survivors to better understand long-term outcomes of the post-ICU family syndrome and to evaluate how it affects patient recovery.

Keywords

References

  1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet 2(7511):319–323
    • View reference on PubMed
    • View reference on publisher's website
  2. Rubenfeld GD, Caldwell E, Peabody E et al (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353(16):1685–1693
    • View reference on PubMed
    • View reference on publisher's website
  3. Elliott CG, Rasmusson BY, Crapo RO, Morris AH, Jensen RL (1987) Prediction of pulmonary function abnormalities after adult respiratory distress syndrome (ARDS). Am Rev Respir Dis 135(3):634–638
    • View reference on PubMed
  4. Ghio AJ, Elliott CG, Crapo RO, Berlin SL, Jensen RL (1989) Impairment after adult respiratory distress syndrome. An evaluation based on American Thoracic Society recommendations. Am Rev Respir Dis 139(5):1158–1162
    • View reference on PubMed
    • View reference on publisher's website
  5. McHugh LG, Milberg JA, Whitcomb ME, Schoene RB, Maunder RJ, Hudson LD (1994) Recovery of function in survivors of the acute respiratory distress syndrome. Am J Respir Crit Care Med 150(1):90–94
    • View reference on PubMed
    • View reference on publisher's website
  6. Davidson TA, Caldwell ES, Curtis JR, Hudson LD, Steinberg KP (1999) Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients. JAMA 281(4):354–360
    • View reference on PubMed
    • View reference on publisher's website
  7. Heyland DK, Groll D, Caeser M (2005) Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life. Crit Care Med 33(7):1549–1556
    • View reference on PubMed
    • View reference on publisher's website
  8. Orme J Jr, Romney JS, Hopkins RO et al (2003) Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 167(5):690–694
    • View reference on PubMed
    • View reference on publisher's website
  9. Angus DC, Clermont G, Linde-Zwirble WT et al (2006) Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 34(12):2883–2890
    • View reference on PubMed
    • View reference on publisher's website
  10. Herridge MS, Tansey CM, Matte A et al (2011) Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 364(14):1293–1304
    • View reference on PubMed
    • View reference on publisher's website
  11. Desai SR, Wells AU, Suntharalingam G, Rubens MB, Evans TW, Hansell DM (2001) Acute respiratory distress syndrome caused by pulmonary and extrapulmonary injury: a comparative CT study. Radiology 218(3):689–693
    • View reference on PubMed
    • View reference on publisher's website
  12. Linden VB, Lidegran MK, Frisen G, Dahlgren P, Frenckner BP, Larsen F (2009) ECMO in ARDS: a long-term follow-up study regarding pulmonary morphology and function and health-related quality of life. Acta Anaesthesiol Scand 53(4):489–495
    • View reference on PubMed
    • View reference on publisher's website
  13. Wilcox ME, Patsios D, Murphy G, Kudlow P, Paul N, Tansey CM, Chu L, Matte A, Tomlinson G, Herridge MS (2013) Radiologic outcomes at 5 years after severe ARDS. Chest 143(4):920–926
    • View reference on PubMed
    • View reference on publisher's website
  14. Angus DC, Musthafa AA, Clermont G et al (2001) Quality-adjusted survival in the first year after the acute respiratory distress syndrome. Am J Respir Crit Care Med 163(6):1389–1394
    • View reference on PubMed
    • View reference on publisher's website
  15. Fan E, Dowdy DW, Colantuoni E et al (2014) Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med 42(4):849–859
    • View reference on PubMed
    • View reference on publisher's website
  16. Herridge MS, Cheung AM, Tansey CM et al (2003) One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 348(8):683–693
    • View reference on PubMed
    • View reference on publisher's website
  17. Needham DM (2014) Understanding and improving clinical trial outcome measures in acute respiratory failure. Am J Respir Crit Care Med 189(8):875–877
    • View reference on PubMed
    • View reference on publisher's website
  18. Weinert CR, Gross CR, Kangas JR, Bury CL, Marinelli WA (1997) Health-related quality of life after acute lung injury. Am J Respir Crit Care Med 156(4 Pt 1):1120–1128
    • View reference on PubMed
    • View reference on publisher's website
  19. Cheung AM, Tansey CM, Tomlinson G et al (2006) Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 174(5):538–544
    • View reference on PubMed
    • View reference on publisher's website
  20. Schelling G, Stoll C, Vogelmeier C et al (2000) Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome. Intensive Care Med 26(9):1304–1311
  21. Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304(16):1787–1794
    • View reference on PubMed
    • View reference on publisher's website
  22. Unroe M, Kahn JM, Carson SS et al (2010) One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med 153(3):167–175
    • View reference on PubMed
    • View reference on publisher's website
  23. Needham DM, Wozniak AW, Hough CL et al (2014) Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med 189(10):1214–1224
    • View reference on PubMed
    • View reference on publisher's website
  24. Kress JP, Hall JB (2014) ICU-acquired weakness and recovery from critical illness. N Engl J Med 371(3):287–288
    • View reference on PubMed
    • View reference on publisher's website
  25. Bolton CF, Gilbert JJ, Hahn AF, Sibbald WJ (1984) Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry 47(11):1223–1231
    • View reference on PubMed
    • View reference on publisher's website
  26. De Jonghe B, Sharshar T, Lefaucheur JP et al (2002) Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 288(22):2859–2867
    • View reference on PubMed
    • View reference on publisher's website
  27. de Letter MA, Schmitz PI, Visser LH et al (2001) Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med 29(12):2281–2286
    • View reference on PubMed
    • View reference on publisher's website
  28. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM (2007) Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 33(11):1876–1891
  29. Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ (2005) Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64(8):1348–1353
    • View reference on PubMed
    • View reference on publisher's website
  30. Pandit L, Agrawal A (2006) Neuromuscular disorders in critical illness. Clin Neurol Neurosurg 108(7):621–627
    • View reference on PubMed
    • View reference on publisher's website
  31. Latronico N, Fenzi F, Recupero D et al (1996) Critical illness myopathy and neuropathy. Lancet 347(9015):1579–1582
    • View reference on PubMed
    • View reference on publisher's website
  32. Angel MJ, Bril V, Shannon P, Herridge MS (2007) Neuromuscular function in survivors of the acute respiratory distress syndrome. Can J Neurol Sci 34(4):427–432
    • View reference on PubMed
    • View reference on publisher's website
  33. Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ (1998) Acute myopathy after liver transplantation. Neurology 50(1):46–53
    • View reference on PubMed
    • View reference on publisher's website
  34. Helliwell TR, Coakley JH, Wagenmakers AJ et al (1991) Necrotizing myopathy in critically-ill patients. J Pathol 164(4):307–314
    • View reference on PubMed
    • View reference on publisher's website
  35. Hudson SJ, Brett SJ (2006) Heterotopic ossification—a long-term consequence of prolonged immobility. Crit Care 10(6):174
    • View reference on PubMed
    • View reference on publisher's website
  36. Wilcox ME, Brummel NE, Archer K, Ely EW, Jackson JC, Hopkins RO (2013) Cognitive dysfunction in ICU patients: risk factors, predictors, and rehabilitation interventions. Crit Care Med 41(9 Suppl 1):S81–S98
    • View reference on PubMed
    • View reference on publisher's website
  37. Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39(3):376–386
  38. Hopkins RO, Weaver LK, Collingridge D, Parkinson RB, Chan KJ, Orme JF Jr (2005) Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 171(4):340–347
    • View reference on PubMed
    • View reference on publisher's website
  39. Kapfhammer HP, Rothenhäusler HB, Krauseneck T, Stoll C, Schelling G (2004) Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome. Am J Psychiatry 161(1):45–52
    • View reference on PubMed
    • View reference on publisher's website
  40. Rothenhausler HB, Ehrentraut S, Stoll C, Schelling G, Kapfhammer HP (2001) The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study. Gen Hosp Psychiatry 23(2):90–96
    • View reference on PubMed
    • View reference on publisher's website
  41. Jackson JC, Girard TD, Gordon SM et al (2010) Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med 182(2):183–191
    • View reference on PubMed
    • View reference on publisher's website
  42. Needham DM, Dinglas VD, Bienvenu OJ et al (2013) One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ 346:f1532
    • View reference on PubMed
    • View reference on publisher's website
  43. Needham DM, Dinglas VD, Morris PE et al (2013) Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 188(5):567–576
    • View reference on PubMed
    • View reference on publisher's website
  44. Pandharipande PP, Girard TD, Jackson JC et al (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369(14):1306–1316
    • View reference on PubMed
    • View reference on publisher's website
  45. Adhikari NK, McAndrews MP, Tansey CM et al (2009) Self-reported symptoms of depression and memory dysfunction in survivors of ARDS. Chest 135(3):678–687
    • View reference on PubMed
    • View reference on publisher's website
  46. Adhikari NK, Tansey CM, McAndrews MP et al (2011) Self-reported depressive symptoms and memory complaints in survivors five years after ARDS. Chest 140(6):1484–1493
    • View reference on PubMed
    • View reference on publisher's website
  47. Pfoh ER, Chan KS, Dinglas VD et al (2015) Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the mini-mental state examination. Crit Care 19:220
    • View reference on PubMed
    • View reference on publisher's website
  48. Woon FL, Dunn CB, Hopkins RO (2012) Predicting cognitive sequelae in survivors of critical illness with cognitive screening tests. Am J Respir Crit Care Med 186(4):333–340
    • View reference on PubMed
    • View reference on publisher's website
  49. Zhao J, Yao L, Wang C, Sun Y, Sun Z (2015) The effects of cognitive intervention on cognitive impairments after intensive care unit admission. Neuropsychol Rehabil 27:1–17
  50. Mikkelsen ME, Christie JD, Lanken PN et al (2012) The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med 185(12):1307–1315
    • View reference on PubMed
    • View reference on publisher's website
  51. Bigler ED, Blatter DD, Anderson CV et al (1997) Hippocampal volume in normal aging and traumatic brain injury. AJNR Am J Neuroradiol 18(1):11–23
    • View reference on PubMed
  52. Hopkins RO, Suchyta MR, Snow GL, Jephson A, Weaver LK, Orme JF (2010) Blood glucose dysregulation and cognitive outcome in ARDS survivors. Brain Inj 24(12):1478–1484
    • View reference on PubMed
    • View reference on publisher's website
  53. Mikkelsen ME LP, Biester R, Gallop R, Bellamy S, Localio AR, Hopkins RO, Angus DC, Christie JD (2008) Conservative fluid strategy is associated with neurocognitive deficits in survivors of acute lung injury. Am J Respir Crit Care Med 177:A819
  54. Needham DM, Colantuoni E, Dinglas VD et al (2016) Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. Lancet Respir Med. doi:10.1016/S2213-2600(16)00005-9
  55. Bienvenu OJ, Neufeld KJ (2011) Post-traumatic stress disorder in medical settings: focus on the critically ill. Curr Psychiatry Rep 13(1):3–9
    • View reference on PubMed
    • View reference on publisher's website
  56. Bienvenu OJ (2014) Depressive mood states following critical illness. In: Stevens RD, Hart N, Herridge M (eds) The legacy of critical illness—a textbook of post-ICU medicine. Oxford University Press, New York, pp 216–231
  57. Needham DM, Davidson J, Cohen H et al (2012) Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders’ conference. Crit Care Med 40(2):502–509
    • View reference on PubMed
    • View reference on publisher's website
  58. Davidson JE, Jones C, Bienvenu OJ (2012) Family response to critical illness: post-intensive care syndrome—family. Crit Care Med 40(2):618–624
    • View reference on PubMed
    • View reference on publisher's website
  59. Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM (2009) Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 35(5):796–809
  60. Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ (2008) Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry 30(5):421–434
    • View reference on PubMed
    • View reference on publisher's website
  61. Parker AM, Sricharoenchai T, Raparla S, Schneck KW, Bienvenu OJ, Needham DM (2015) Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med 43(5):1121–1129
    • View reference on PubMed
    • View reference on publisher's website
  62. Davydow DS, Desai SV, Needham DM, Bienvenu OJ (2008) Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med 70(4):512–519
    • View reference on PubMed
    • View reference on publisher's website
  63. Herridge MS, Angus DC (2005) Acute lung injury: affecting many lives. New Engl J Med 353(16):1736–1738
    • View reference on PubMed
    • View reference on publisher's website
  64. Schelling G, Stoll C, Haller M et al (1998) Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 26(4):651–659
    • View reference on PubMed
    • View reference on publisher's website
  65. Deja M, Denke C, Weber-Carstens S et al (2006) Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome. Crit Care 10(5):R147
    • View reference on PubMed
    • View reference on publisher's website
  66. Hopkins RO, Weaver LK, Chan KJ, Orme JF Jr (2004) Quality of life, emotional, and cognitive function following acute respiratory distress syndrome. J Int Neuropsychol Soc 10(7):1005–1017
    • View reference on PubMed
  67. Schelling G, Kapfhammer HP (2013) Surviving the ICU does not mean that the war is over. Chest 144(1):1–3
    • View reference on PubMed
    • View reference on publisher's website
  68. Christie JD, Biester RC, Taichman DB et al (2006) Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors. J Crit Care 21(2):125–132
    • View reference on PubMed
    • View reference on publisher's website
  69. Nelson JE, Cox CE, Hope AA, Carson SS (2010) Chronic critical illness. Am J Respir Crit Care Med 182(4):446–454
    • View reference on PubMed
    • View reference on publisher's website
  70. Shaw RJ, Harvey JE, Nelson KL, Gunary R, Kruk H, Steiner H (2001) Linguistic analysis to assess medically related posttraumatic stress symptoms. Psychosomatics 42(1):35–40
    • View reference on PubMed
    • View reference on publisher's website
  71. Stoll C, Kapfhammer HP, Rothenhausler HB et al (1999) Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med 25(7):697–704
  72. Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2012) Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study. Am J Respir Crit Care Med 185(5):517–524
    • View reference on PubMed
    • View reference on publisher's website
  73. Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2015) Cooccurrence of and remission from general anxiety, depression, and posttraumatic stress disorder symptoms after acute lung injury: a 2-year longitudinal study. Crit Care Med 43(3):642–653
    • View reference on PubMed
    • View reference on publisher's website
  74. Bienvenu OJ, Gellar J, Althouse BM et al (2013) Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study. Psychol Med 43(12):2657–2671
    • View reference on PubMed
    • View reference on publisher's website
  75. Bienvenu OJ, Williams JB, Yang A, Hopkins RO, Needham DM (2013) Posttraumatic stress disorder in survivors of acute lung injury: evaluating the impact of event scale-revised. Chest 144(1):24–31
    • View reference on PubMed
    • View reference on publisher's website
  76. Dowdy DW, Bienvenu OJ, Dinglas VD et al (2009) Are intensive care factors associated with depressive symptoms 6 months after acute lung injury? Crit Care Med 37(5):1702–1707
    • View reference on PubMed
    • View reference on publisher's website
  77. Dowdy DW, Dinglas V, Mendez-Tellez PA et al (2008) Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury. Crit Care Med 36(10):2726–2733
    • View reference on PubMed
    • View reference on publisher's website
  78. Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF Jr (2010) Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry 32(2):147–155
    • View reference on PubMed
    • View reference on publisher's website
  79. Huang M, Parker AM, Bienvenu OJ et al (2016) Psychiatric symptoms in acute respiratory distress syndrome survivors: a 1-year national multicenter study. Crit Care Med (in press)
  80. Jutte JE, Needham DM, Pfoh ER, Bienvenu OJ (2015) Psychometric evaluation of the hospital anxiety and depression scale 3 months after acute lung injury. J Crit Care 30(4):793–798
    • View reference on PubMed
    • View reference on publisher's website
  81. Stevenson JE, Colantuoni E, Bienvenu OJ et al (2013) General anxiety symptoms after acute lung injury: predictors and correlates. J Psychosom Res 75(3):287–293
    • View reference on PubMed
    • View reference on publisher's website
  82. Needham DM, Dennison CR, Dowdy DW et al (2006) Study protocol: the improving care of acute lung injury patients (ICAP) study. Crit Care 10(1):R9
    • View reference on PubMed
    • View reference on publisher's website
  83. Herridge M, Cameron JI (2013) Disability after critical illness. N Engl J Med 369(14):1367–1369
    • View reference on PubMed
    • View reference on publisher's website
  84. Garrouste-Orgeas M, Coquet I, Périer A et al (2012) Impact of an intensive care unit diary on psychological distress in patients and relatives. Crit Care Med 40:2033–2040
    • View reference on PubMed
    • View reference on publisher's website
  85. Jones C, Bäckman C, Capuzzo M et al (2010) Intensive care diaries reduce new-onset post-traumatic stress disorder following critical illness: a randomised, controlled trial. Crit Care 14:R168
    • View reference on PubMed
    • View reference on publisher's website
  86. Aitken LM, Rattray A, Hull A, Kenardy JA, Le Brocque R, Ullman AJ (2013) The use of diaries in psychological recovery from intensive care. Crit Care 17:253
    • View reference on PubMed
    • View reference on publisher's website
  87. Ullman AJ, Aitken LM, Rattray J et al (2014) Diaries for recovery from critical illness. Cochrane Database Syst Rev 12:CD010468
  88. Cox CE, Porter LS, Hough CL et al (2012) Development and preliminary evaluation of a telephone-based coping skills training intervention for survivors of acute lung injury and their informal caregivers. Intensive Care Med 38(8):1289–1297
  89. Peris A, Bonizzoli M, Iozzelli D et al (2011) Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients. Crit Care 15(1):R41
    • View reference on PubMed
    • View reference on publisher's website
  90. Girard TD, Jackson JC, Pandharipande PP et al (2010) Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 38(7):1513–1520
    • View reference on PubMed
    • View reference on publisher's website
  91. Jackson JC, Pandharipande PP, Girard TD et al (2014) Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2(5):369–379
    • View reference on PubMed
    • View reference on publisher's website
  92. Devlin JW, Garpestad E, Hill NS (2010) Neuromuscular blockers and ARDS. N Engl J Med 363(26):2562 (author reply 2563–2564)
    • View reference on PubMed
    • View reference on publisher's website
  93. Girard TD, Pandharipande PP, Carson SS et al (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38(2):428–437
    • View reference on PubMed
    • View reference on publisher's website
  94. Girard TD, Kress JP, Fuchs BD et al (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial. Lancet 371(9607):126–134
    • View reference on PubMed
    • View reference on publisher's website
  95. Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342(20):1471–1477
    • View reference on PubMed
    • View reference on publisher's website
  96. Strom T, Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375(9713):475–480
    • View reference on PubMed
    • View reference on publisher's website
  97. Strawn JR, Geracioti TD Jr (2008) Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety 25(3):260–271
    • View reference on PubMed
    • View reference on publisher's website
  98. Krauseneck T, Padberg F, Roozendaal B et al (2010) A beta-adrenergic antagonist reduces traumatic memories and PTSD symptoms in female but not in male patients after cardiac surgery. Psychol Med 40(5):861–869
    • View reference on PubMed
    • View reference on publisher's website
  99. Wei X, Day AG, Ouellette-Kuntz H, Heyland DK (2015) The association between nutritional adequacy and long-term outcomes in critically ill patients requiring prolonged mechanical ventilation: a multicenter cohort study. Crit Care Med 43(8):1569–1579
    • View reference on PubMed
    • View reference on publisher's website
  100. Rice TW, Wheeler AP, Thompson BT et al (2012) Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 307(8):795–803
    • View reference on PubMed
    • View reference on publisher's website
  101. Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP (2011) Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med 39(5):967–974
    • View reference on PubMed
    • View reference on publisher's website
  102. Brummel NE, Girard TD, Ely EW et al (2014) Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the activity and cognitive therapy in ICU (ACT-ICU) trial. Intensive Care Med 40(3):370–379
  103. Heyland DK, Stapleton RD, Mourtzakis M et al (2015) Combining nutrition and exercise to optimize survival and recovery from critical illness: conceptual and methodological issues. Clin Nutr. doi:10.1016/j.clnu.2015.07.003
  104. Wischmeyer PE, San-Millan I (2015) Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. Crit Care 19(Suppl 3):S6
    • View reference on PubMed
  105. Papazian L, Forel JM, Gacouin A et al (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363(12):1107–1116
    • View reference on PubMed
    • View reference on publisher's website
  106. Bice T, Cox CE, Carson SS (2013) Cost and health care utilization in ARDS—different from other critical illness? Semin Respir Crit Care Med 34(4):529–536
    • View reference on PubMed
    • View reference on publisher's website
  107. The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group (1991) Perioperative total parenteral nutrition in surgical patients. N Engl J Med 325(8):525–532
    • View reference on publisher's website
  108. Hamel MB, Phillips RS, Davis RB et al (2000) Outcomes and cost-effectiveness of ventilator support and aggressive care for patients with acute respiratory failure due to pneumonia or acute respiratory distress syndrome. Am J Med 109(8):614–620
    • View reference on PubMed
    • View reference on publisher's website
  109. Sznajder M, Aegerter P, Launois R, Merliere Y, Guidet B (2001) CubRea. A cost-effectiveness analysis of stays in intensive care units. Intensive Care Med 27(1):146–153
  110. Talmor D, Greenberg D, Howell MD, Lisbon A, Novack V, Shapiro N (2008) The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med 36(4):1168–1174
    • View reference on PubMed
    • View reference on publisher's website
  111. Prescott HC, Langa KM, Liu V, Escobar GJ, Iwashyna TJ (2014) Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med 190(1):62–69
    • View reference on PubMed
    • View reference on publisher's website
  112. Needham DM (2008) Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical function. JAMA 300(14):1685–1690
    • View reference on PubMed
    • View reference on publisher's website
  113. Bailey P, Thomsen GE, Spuhler VJ et al (2007) Early activity is feasible and safe in respiratory failure patients. Crit Care Med 35(1):139–145
    • View reference on PubMed
    • View reference on publisher's website
  114. Morris PE (2007) Moving our critically ill patients: mobility barriers and benefits. Crit Care Clin 23(1):1–20
    • View reference on PubMed
    • View reference on publisher's website
  115. Morris PE, Griffin L, Berry M et al (2011) Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci 341(5):373–377
    • View reference on PubMed
    • View reference on publisher's website
  116. Schweickert WD, Pohlman MC, Pohlman AS et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882
    • View reference on PubMed
    • View reference on publisher's website
  117. Burtin C, Clerckx B, Robbeets C et al (2009) Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 37(9):2499–2505
    • View reference on PubMed
    • View reference on publisher's website
  118. Moss M, Nordon-Craft A, Malone D et al (2015) A randomized trial of an intensive physical therapy program for acute respiratory failure patients. Am J Respir Crit Care Med. doi:10.1164/rccm.201505-1039OC
  119. Jones C, Skirrow P, Griffiths RD et al (2003) Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med 31(10):2456–2461
    • View reference on PubMed
    • View reference on publisher's website
  120. Cuthbertson BH, Rattray J, Campbell MK et al (2009) The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial. BMJ 339:b3723
    • View reference on PubMed
    • View reference on publisher's website
  121. Elliott D, McKinley S, Alison J et al (2011) Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care 15(3):R142
    • View reference on PubMed
    • View reference on publisher's website
  122. Denehy L, Skinner EH, Edbrooke L et al (2013) Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care 17(4):R156
    • View reference on PubMed
    • View reference on publisher's website
  123. Walsh TS, Salisbury LG, Merriweather JL et al (2015) Increased hospital-based physical rehabilitation and information provision after intensive care unit discharge: the recover randomized clinical trial. JAMA Intern Med 175(6):901–910
    • View reference on PubMed
    • View reference on publisher's website
  124. Harrold ME, Salisbury LG, Webb SA, Allison GT, Australia and Scotland ICU Physiotherapy Collaboration (2015) Australia, Scotland ICUPC. Early mobilisation in intensive care units in Australia and Scotland: a prospective, observational cohort study examining mobilisation practises and barriers. Crit Care 19:336
    • View reference on PubMed
    • View reference on publisher's website
  125. Puntillo K, Nelson JE, Weissman D et al (2014) Palliative care in the ICU: relief of pain, dyspnea, and thirst—a report from the IPAL-ICU Advisory Board. Intensive Care Med 40(2):235–248
  126. Azoulay E, Citerio G, Bakker J et al (2014) Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients. Intensive Care Med 40(3):305–319
  127. Jabre P, Tazarourte K, Azoulay E et al (2014) Offering the opportunity for family to be present during cardiopulmonary resuscitation: 1-year assessment. Intensive Care Med 40(7):981–987
  128. Verceles AC, Corwin DS, Afshar M et al (2014) Half of the family members of critically ill patients experience excessive daytime sleepiness. Intensive Care Med 40(8):1124–1131
  129. Bouju P, Tadie JM, Uhel F et al (2014) Internet use by family members of intensive care unit patients: a pilot study. Intensive Care Med 40(8):1175–1176
  130. Curtis JR, Sprung CL, Azoulay E (2014) The importance of word choice in the care of critically ill patients and their families. Intensive Care Med 40(4):606–608
  131. Debaty G, Ageron FX, Minguet L et al (2015) More than half the families of mobile intensive care unit patients experience inadequate communication with physicians. Intensive Care Med 41(7):1291–1298
  132. Pochard F, Darmon M, Fassier T et al (2005) Symptoms of anxiety and depression in family members of intensive care unit patients before discharge or death. A prospective multicenter study. J Crit Care 20(1):90–96
    • View reference on PubMed
    • View reference on publisher's website
  133. Long AC, Kross EK, Davydow DS, Curtis JR (2014) Posttraumatic stress disorder among survivors of critical illness: creation of a conceptual model addressing identification, prevention, and management. Intensive Care Med 40(6):820–829
  134. Cox CE, Docherty SL, Brandon DH et al (2009) Surviving critical illness: acute respiratory distress syndrome as experienced by patients and their caregivers. Crit Care Med 37(10):2702–2708
    • View reference on PubMed
    • View reference on publisher's website
  135. Evans RL, Bishop DS, Haselkorn JK (1991) Factors predicting satisfactory home care after stroke. Arch Phys Med Rehabil 72(2):144–147
    • View reference on PubMed
  136. Kao HF, McHugh ML (2004) The role of caregiver gender and caregiver burden in nursing home placements for elderly Taiwanese survivors of stroke. Res Nurs Health 27(2):121–134
    • View reference on PubMed
    • View reference on publisher's website
  137. Chelluri L, Im KA, Belle SH et al (2004) Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 32(1):61–69
    • View reference on PubMed
    • View reference on publisher's website
  138. Cameron JI, Herridge MS, Tansey CM, McAndrews MP, Cheung AM (2006) Well-being in informal caregivers of survivors of acute respiratory distress syndrome. Crit Care Med 34(1):81–86
    • View reference on PubMed
    • View reference on publisher's website
  139. Johnson P, Chaboyer W, Foster M, van der Vooren R (2001) Caregivers of ICU patients discharged home: what burden do they face? Intensive Crit Care Nurs 17(4):219–227
    • View reference on PubMed
    • View reference on publisher's website
  140. Van Pelt DC, Milbrandt EB, Qin L et al (2007) Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med 175(2):167–173
    • View reference on PubMed
    • View reference on publisher's website
  141. Rier DA (2014) From three sides now: reflections on an ICU journey as patient, parent, and researcher. Intensive Care Med 40(8):1162–1163
  142. Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson LV (1999) Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 160(1):50–56
    • View reference on PubMed
    • View reference on publisher's website
  143. Mikkelsen ME, Shull WH, Biester RC, et al (2009) Cognitive, mood and quality of life impairments in a select population of ARDS survivors. Respirology 14(1):76–82
    • View reference on publisher's website
  144. Jackson JC, Hopkins RO, Miller RR, Gordon SM, Wheeler AP, Ely EW (2009) Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study. South Med J 102(11):1150–1157
    • View reference on PubMed
    • View reference on publisher's website

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