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Is the literature inconclusive about the harm from HES? No

Christian J. Wiedermann| Rinaldo Bellomo| Anders Perner
Editorial
Volume 43, Issue 10 / October , 2017

Pages 1523 - 1525

No abstract available.

References

  1. Mutter TC, Ruth CA, Dart AB (2013) Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function. Cochrane Database Syst Rev 7:CD007594
  2. Myburgh JA, Finfer S, Bellomo R et al (2012) Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 367:1901–1911
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  3. Haase N, Perner A, Hennings LI et al (2013) Hydroxyethyl starch 130/0.38–0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis. BMJ 346:f839
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  4. Rochwerg B, Alhazzani W, Gibson A et al (2015) Fluid type and the use of renal replacement therapy in sepsis: a systematic review and network meta-analysis. Intensive Care Med 41:1561–1571. doi:10.1007/s00134-015-3794-1
  5. Wilkes MM, Navickis R (2014) Postoperative renal replacement therapy after hydroxyethyl starch infusion: a meta-analysis of randomised trials. Neth J Crit Care 18:4–9
  6. Bellmann R, Feistritzer C, Wiedermann CJ (2012) Effect of molecular weight and substitution on tissue uptake of hydroxyethyl starch: a meta-analysis of clinical studies. Clin Pharmacokinet 51:225–236
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  7. Wiedermann CJ, Joannidis M (2014) Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review. Intensive Care Med 40:160–170
  8. Claus RA, Sossdorf M, Hartog C et al (2010) The effects of hydroxyethyl starch on cultured renal epithelial cells. Anesth Analg 110:300–301
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  9. Haase N, Wetterslev J, Winkel P, Perner A (2013) Bleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial. Intensive Care Med 39:2126–2134
  10. Rasmussen KC, Johansson PI, Højskov M et al (2014) Hydroxyethyl starch reduces coagulation competence and increases blood loss during major surgery: results from a randomized controlled trial. Ann Surg 259:249–254
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  11. Kancir AS, Johansen JK, Ekeloef NP et al (2015) The effect of 6 % hydroxyethyl starch 130/0.4 on renal function, arterial blood pressure, and vasoactive hormones during radical prostatectomy: a randomized controlled trial. Anesth Analg 120:608–618
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  12. Navickis RJ, Haynes GR, Wilkes MM (2012) Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: a meta-analysis of randomized trials. J Thorac Cardiovasc Surg 144:223–230
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  13. Jacob M, Fellahi JL, Chappell D et al (2014) The impact of hydroxyethyl starches in cardiac surgery: a meta-analysis. Crit Care 18:656
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  14. Hartog CS, Reuter D, Loesche W et al (2011) Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review. Intensive Care Med 37:1725–1737
  15. Perner A, Haase N, Guttormsen AB et al (2012) Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 367:124–134
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  16. Perel P, Roberts I, Ker K (2013) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2:CD000567
  17. Zarychanski R, Abou-Setta AM, Turgeon AF et al (2013) Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA 309:678–688
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  18. Annane D, Siami S, Jaber S et al (2013) Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA 310:1809–1817
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  19. Savović J, Jones HE, Altman DG et al (2012) Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med 157:429–438
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  20. Hartog CS, Reinhart K (2012) CRYSTMAS study adds to concerns about renal safety and increased mortality in sepsis patients. Crit Care 16:454
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