Log in | Register

Acquiring knowledge in intensive care: merits and pitfalls of randomized controlled trials

Luciano Gattinoni| Pierpaolo Giomarelli
Editorial
Volume 41, Issue 8 / August , 2015

Pages 1460 - 1464

No abstract available.

References

  1. Zapol WM, Snider MT, Hill JD, Fallat RJ, Bartlett RH, Edmunds LH et al (1979) Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA 242:2193–2196
    • View reference on PubMed
    • View reference on publisher's website
  2. The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308
  3. Gattinoni L, Carlesso E, Cadringher P, Valenza F, Vagginelli F, Chiumello D (2003) Physical and biological triggers of ventilator-induced lung injury and its prevention. Eur Respir J Suppl 47:15s–25s
    • View reference on PubMed
    • View reference on publisher's website
  4. Amato MBP, Meade MO, Slutsky AS, Brochard L, Costa ELV, Schoenfeld DA et al (2015) Driving pressure and survival in the acute respiratory distress syndrome. New Engl J Med 372:747–755
    • View reference on PubMed
    • View reference on publisher's website
  5. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M et al (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. New Engl J Med 351:327–336
    • View reference on PubMed
    • View reference on publisher's website
  6. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ et al (2008) Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299:637–645
    • View reference on PubMed
    • View reference on publisher's website
  7. Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL et al (2008) Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299:646–655
    • View reference on PubMed
    • View reference on publisher's website
  8. Gattinoni L, Tognoni G, Pesenti A, Taccone P, Mascheroni D, Labarta V et al (2001) Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 345:568–573
    • View reference on PubMed
    • View reference on publisher's website
  9. Guerin C, Gaillard S, Lemasson S, Ayzac L, Girard R, Beuret P et al (2004) Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA 292:2379–2387
    • View reference on PubMed
    • View reference on publisher's website
  10. Mancebo J, Fernandez R, Blanch L, Rialp G, Gordo F, Ferrer M et al (2006) A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 173:1233–1239
    • View reference on PubMed
    • View reference on publisher's website
  11. Taccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C et al (2009) Prone positioning in patients with moderate and severe acute respiratory distress syndrome a randomized controlled trial. J Am Med Assoc 302:1977–1984
    • View reference on publisher's website
  12. Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T et al (2013) Prone positioning in severe acute respiratory distress syndrome. New Engl J Med 368:2159–2168
    • View reference on PubMed
    • View reference on publisher's website
  13. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377
    • View reference on PubMed
    • View reference on publisher's website
  14. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F et al (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693
    • View reference on PubMed
    • View reference on publisher's website
  15. The ARISE Investigators and the ANZICS Clinical Trials Group (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506
    • View reference on publisher's website
  16. Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD et al (2015) Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:1301–1311

Sign In

Connect with ICM

Top 5 Articles Editors Picks Supplement