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Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria

Matthieu Legrand| Aurélien Jacquemod| Etienne Gayat| Corinne Collet| Veronique Giraudeaux| Jean-Marie Launay| Didier Payen
Original
Volume 41, Issue 1 / January , 2015

Pages 68 - 76

Abstract

Purpose

Oliguria is a common symptom in critically ill patients and puts patients in a high risk category for further worsening renal function (WRF). We performed this study to explore the predictive value of biomarkers to predict WRF in oliguric intensive care unit (ICU) patients.

Patients and methods

Single-center prospective observational study. ICU patients were included when they presented a first episode of oliguria. Plasma and urine biomarkers were measured: plasma and urine neutrophil gelatinase-associated lipocalin (pNGAL and uNGAL), urine α1-microglobulin, urine γ-glutamyl transferase, urine indices of tubular function, cystatin C, C terminal fragment of pro-arginine vasopressin (CT-ProAVP), and proadrenomedullin (MR-ProADM).

Results

One hundred eleven patients formed the cohort, of whom 43 had worsening renal function. Simplified Acute Physiology Score (SAPS) II was 41 (31–51). WRF was associated with increased mortality (hazard ratio 8.65 [95 % confidence interval (CI) 3.0–24.9], p = 0.0002). pNGAL, MR-ProADM, and cystatin C had the best odds ratio and area under the receiver-operating characteristic curve (AUC-ROC: 0.83 [0.75–0.9], 0.82 [0.71–0.91], and 0.83 [0.74–0.90]), but not different from serum creatinine (Screat, 0.80 [0.70–0.88]). A clinical model that included age, sepsis, SAPS II, and Screat had AUC-ROC of 0.79 [0.69–0.87]; inclusion of pNGAL increased the AUC-ROC to 0.86 (p = 0.03). The category-free net reclassification index improved with pNGAL (total net reclassification index for events to higher risk 61 % and nonevents to lower 82 %).

Conclusions

All episodes of oliguria do not carry the same risk. No biomarker further improved prediction of WRF compared with Screat in this selected cohort of patients at increased risk defined by oliguria.

Keywords

References

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