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Impact of de-escalation on ICU patients’ prognosis

Jan J. De Waele| Matteo Bassetti| Ignacio Martin-Loeches
Editorial
Volume 40, Issue 10 / October , 2014

Pages 1583 - 1585

No abstract available.

References

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  2. Rello J, Vidaur L, Sandiumenge A, Rodriguez A, Gualis B, Boque C, Diaz E (2004) De-escalation therapy in ventilator-associated pneumonia. Crit Care Med 32:2183–2190
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  3. Kollef MH, Morrow LE, Niederman MS, Leeper KV, Anzueto A, Benz-Scott L, Rodino FJ (2006) Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia. Chest 129:1210–1218
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  4. De Waele JJ, Ravyts M, Depuydt P, Blot SI, Decruyenaere J, Vogelaers D (2010) De-escalation after empirical meropenem treatment in the intensive care unit: fiction or reality? J Crit Care 25:641–646
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  5. Heenen S, Jacobs F, Vincent JL (2012) Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often? Crit Care Med 40:1404–1409
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  6. Montravers P, Dupont H, Gauzit R, Veber B, Bedos JP, Lepape A (2011) Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units. Crit Care 15:R17
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  7. Garnacho-Montero J, Gutierrez-Pizarraya A, Escoresca-Ortega A, Corcia-Palomo Y, Fernandez-Delgado E, Herrera-Melero I, Ortiz-Leyba C, Marquez-Vacaro JA (2014) De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med 40:32–40
  8. Leone M, Bechis C, Baumstarck K, Lefrant JY, Albanese J, Jaber S, Lepape A, Constantin JM, Papazian L, Bruder N, Allaouchiche B, Bezulier K, Antonini F, Textoris J, Martin C (2014) De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial. Intensive Care Med. doi:10.1007/s00134-014-3411-8
  9. Mokart D, Slehofer G, Lambert J, Sannini A, Chow-Chine L, Brun JP, Berger P, Duran S, Faucher M, Blache JL, Saillard C, Vey N, Leone M (2014) De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study. Intensive Care Med 40:41–49
  10. Martin-Loeches I, Diaz E, Valles J (2014) Risks for multidrug-resistant pathogens in the ICU. Curr Opin Crit Care 20:516–524

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