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Antibiotic dosing in the critically ill: asking the same questions but expecting different answers

P. Póvoa| I. Spriet| J. R. Zahar
Editorial
Volume 40, Issue 11 / November , 2014

Pages 1780 - 1782

No abstract available.

References

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  2. De Waele JJ, Lipman J, Akova M, Bassetti M, Dimopoulos G, Kaukonen M, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Udy AA, Starr T, Wallis SC, Roberts JA (2014) Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients. Intensive Care Med 40:1340–1351. doi:10.1007/s00134-014-3403-8
  3. Roberts JA, De Waele JJ, Dimopoulos G, Koulenti D, Martin C, Montravers P, Rello J, Rhodes A, Starr T, Wallis SC, Lipman J (2012) DALI: defining antibiotic levels in intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic. BMC Infect Dis 12:152
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  4. Baptista JP, Udy AA, Sousa E, Pimentel J, Wang L, Roberts JA, Lipman J (2011) A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance. Crit Care 15:R139
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  5. Baptista JP, Neves M, Rodrigues L, Teixeira L, Pinho J, Pimentel J (2014) Accuracy of the estimation of glomerular filtration rate within a population of critically ill patients. J Nephrol 27:403–410
  6. Goncalves-Pereira J, Povoa P (2011) Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of beta-lactams. Crit Care 15:R206
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  7. Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL, International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases (2014) Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis 14:498–509
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  8. Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Lipman J (2013) Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial. Clin Infect Dis 56:236–244
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  9. De Waele JJ, Carrette S, Carlier M, Stove V, Boelens J, Claeys G, Leroux-Roels I, Hoste E, Depuydt P, Decruyenaere J, Verstraete AG (2014) Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial. Intensive Care Med 40:380–387
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  11. Chapuis TM, Giannoni E, Majcherczyk PA, Chiolero R, Schaller MD, Berger MM, Bolay S, Decosterd LA, Bugnon D, Moreillon P (2010) Prospective monitoring of cefepime in intensive care unit adult patients. Crit Care 14:R51
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  12. Goncalves-Pereira J, Oliveira BS, Janeiro S, Estilita J, Monteiro C, Salgueiro A, Vieira A, Gouveia J, Paulino C, Bento L, Povoa P (2012) Continuous infusion of piperacillin/tazobactam in septic critically ill patients—a multicenter propensity matched analysis. PLoS One 7:e49845
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  13. Mohd Hafiz AA, Staatz CE, Kirkpatrick CM, Lipman J, Roberts JA (2012) Continuous infusion vs. bolus dosing: implications for beta-lactam antibiotics. Minerva Anestesiol 78:94–104
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