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De-escalation in severe sepsis: still an important part of our armamentarium against antimicrobial resistance

Garima Kapoor| Saurabh Saigal
Volume 40, Issue 10 / October , 2014

Page 1618

No abstract available.


  1. Maragakis LL (2010) Recognition and prevention of multidrug-resistant gram negative bacteria in the intensive care unit. Crit Care Med 38(8 Suppl):S345–S351
    • View reference on PubMed
    • View reference on publisher's website
  2. Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228
  3. Leone M, Bechis C, Baumstarck K et al (2014) De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial. Intensive Care Med. doi:10.1007/s00134-014-3411-8
  4. Garnacho-Montero J, Gutiérrez-Pizarraya A, Escoresca-Ortega A, Corcia-Palomo Y, Fernández-Delgado E, Herrera-Melero I, Ortiz-Leyba C, Márquez-Vácaro JA (2014) De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med 40:32–40

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