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Understanding paracetamol-induced liver failure

Fin Stolze Larsen| Julia Wendon
Understanding the Disease
Volume 40, Issue 6 / June , 2014

Pages 888 - 890

No abstract available.

References

  1. Prescott LF (1979) Paracetamol poisoning. Prevention of liver damage. Med Chir Dig 8:391–393
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  2. Khalid SK, Lane J, Navarro V, Garcia-Tsao G (2009) Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis. Clin Gastroenterol Hepatol 7(9):994–999
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  3. Prescott LF (1996) Hepatotoxicity. In: Prescott LF (ed) Paracetamol (acetaminophen): a critical bibliographic review. Taylor & Francis, London, pp 285–351
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  6. Bernal W, Wendon J (2013) Acute liver failure. N Engl J Med 369(26):2525–2534
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  7. Schmidt LE, Larsen FS (2006) Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med 34(2):337–343
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  8. Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P (1999) Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29(3):648–653
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  9. Shawcross DL, Wendon JA (2012) The neurological manifestations of acute liver failure. Neurochem Int 60(7):662–671
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  10. Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, O’Brien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M (2013) Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure. Hepatology 59(4):1564–1576. doi:10.1002/hep.26933
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  11. Stravitz RT, Lisman T, Luketic VA et al (2012) Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography. J Hepatol 56:129–136
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  12. Simpson KJ, Bates CM, Henderson NC et al (2009) The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. Liver Transpl 15:600–609
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  13. Harrison PM, Keays R, Bray GP, Alexander GJ, Williams R (1990) Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet 335(8705):1572–1573
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  14. Schmidt LE, Wang LP, Hansen BA, Larsen FS (2003) Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl 9(3):290–297
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