Log in | Register

Intracranial bleeding due to vitamin K deficiency: advantages of using a pediatric intensive care registryOpen access

Désirée Y. Visser| Nicolaas J. Jansen| Marloes M. Ijland| Tom J. de Koning| Peter M. van Hasselt
Pediatric Original
Volume 37, Issue 6 / June , 2011

Pages 1014 - 1020

Abstract

Aim

To determine the incidence of late intracranial vitamin K deficiency bleeding (VKDB) in The Netherlands using the Dutch Pediatric Intensive Care Evaluation (PICE) registry.

Methods

The PICE registry was used to identify all infants who were admitted to a Dutch pediatric intensive care unit (PICU) with intracranial bleeding between 1 January 2004 and 31 December 2007. Cases of confirmed late intracranial VKDB were used to calculate the incidence for each year. To estimate the completeness of ascertainment of the PICE registry, data from 2005 were compared with general surveillance data from that year.

Results

In the 4-year study period, 16/64 (25%) of the infants admitted with intracranial bleeding had late intracranial VKDB, resulting in an overall incidence of 2.1/100,000 live births (95% confidence interval 1.2–3.5). The single-year incidence varied markedly between 0.5 and 3.3 per 100,000 live births. All five ascertained cases in 2005 were identified using the PICE registry, while general surveillance identified only three.

Conclusions

The PICE registry allows ongoing monitoring of the incidence of late intracranial VKDB and appears to be associated with a higher rate of completeness than general surveillance. We propose the use of pediatric intensive care registries to assess the efficacy of national vitamin K prophylactic regimens.

Keywords

References

  1. Chuansumrit A, Isarangkura P, Hathirat P (1998) Vitamin K deficiency bleeding in Thailand: a 32-year history. Southeast Asian J Trop Med Public Health 29:649–654
    • View reference on PubMed
  2. Cornelissen M, von Kries R, Loughnan P, Schubiger G (1997) Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 156:126–130
    • View reference on PubMed
    • View reference on publisher's website
  3. IJland MM, Pereira RR, Cornelissen EA (2008) Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline. Eur J Pediatr 167:165–169
    • View reference on PubMed
    • View reference on publisher's website
  4. McMillan DD, Grenier D, Medaglia A (2004) Canadian Paediatric Surveillance Program confirms low incidence of hemorrhagic disease of the newborn in Canada. Paediatr Child Health 9:235–238
    • View reference on PubMed
  5. McNinch A, Busfield A, Tripp J (2007) Vitamin K deficiency bleeding in Great Britain and Ireland: British Paediatric Surveillance Unit Surveys, 1993–94 and 2001–02. Arch Dis Child 92:759–766
    • View reference on PubMed
    • View reference on publisher's website
  6. Schubiger G, Berger TM, Weber R, Banziger O, Laubscher B (2003) Prevention of vitamin K deficiency bleeding with oral mixed micellar phylloquinone: results of a 6-year surveillance in Switzerland. Eur J Pediatr 162:885–888
    • View reference on PubMed
    • View reference on publisher's website
  7. Sutor AH, Dagres N, Niederhoff H (1995) Late form of vitamin K deficiency bleeding in Germany. Klin Padiatr 207:89–97
    • View reference on PubMed
    • View reference on publisher's website
  8. Sutor AH, von Kries R, Cornelissen EA, McNinch AW, Andrew M (1999) Vitamin K deficiency bleeding (VKDB) in infancy. ISTH pediatric/perinatal subcommittee. International society on thrombosis and haemostasis. Thromb Haemost 81:456–461
    • View reference on PubMed
  9. van Hasselt PM, de Koning TJ, Kvist N, de Vries E, Lundin CR, Berger R, Kimpen JL, Houwen RH, Jorgensen MH, Verkade HJ (2008) Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries. Pediatrics 121:e857–e863
    • View reference on PubMed
    • View reference on publisher's website
  10. von Kries R, Hachmeister A, Gobel U (2003) Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 88:F109–F112
    • View reference on publisher's website
  11. Cekinmez M, Cemil T, Cekinmez EK, Altinors N (2008) Intracranial hemorrhages due to late-type vitamin K deficiency bleeding. Childs Nerv Syst 24:821–825
    • View reference on PubMed
    • View reference on publisher's website
  12. Chaou WT, Chou ML, Eitzman DV (1984) Intracranial hemorrhage and vitamin K deficiency in early infancy. J Pediatr 105:880–884
    • View reference on PubMed
    • View reference on publisher's website
  13. Lane PA, Hathaway WE (1985) Vitamin K in infancy. J Pediatr 106:351–359
    • View reference on PubMed
    • View reference on publisher's website
  14. Cornelissen EA, Hirasing RA, Monnens LA (1996) Prevalence of hemorrhages due to vitamin K deficiency in The Netherlands, 1992–1994. Ned Tijdschr Geneeskd 140:935–937
    • View reference on PubMed
  15. van Hasselt PM, Kok K, Vorselaars AD, van Vlerken L, Nieuwenhuys E, de Koning TJ, de Vries RA, Houwen RH (2009) Vitamin K deficiency bleeding in cholestatic infants with alpha-1-antitrypsin deficiency. Arch Dis Child Fetal Neonatal Ed 94:F456–F460
    • View reference on PubMed
    • View reference on publisher's website
  16. Uitentuis J (1990) Administration of vitamin K to neonates and infants. Ned Tijdschr Geneeskd 134:1642–1646
    • View reference on PubMed
  17. Chapman DG (1951) Some properties of the hypergeometric distribution with applications to zoological censuses. Univ Calif Public Stat 1:131–160
  18. Papoz L, Balkau B, Lellouch J (1996) Case counting in epidemiology: limitations of methods based on multiple data sources. Int J Epidemiol 25:474–478
    • View reference on PubMed
    • View reference on publisher's website
  19. Danielsson N, Hoa DP, Thang NV, Vos T, Loughnan PM (2004) Intracranial haemorrhage due to late onset vitamin K deficiency bleeding in Hanoi province, Vietnam. Arch Dis Child Fetal Neonatal Ed 89:F546–F550
    • View reference on PubMed
    • View reference on publisher's website
  20. LaRovere JM, Jeffries HE, Sachdeva RC, Rice TB, Wetzel RC, Cooper DS, Bird GL, Ghanayem NS, Checchia PA, Chang AC, Wessel DL (2008) Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease—the perspective of critical care. Cardiol Young 18(Suppl 2):130–136
    • View reference on PubMed
    • View reference on publisher's website
  21. Akiyama H, Okamura Y, Nagashima T, Yokoi A, Muraji T, Uetani Y (2006) Intracranial hemorrhage and vitamin K deficiency associated with biliary atresia: summary of 15 cases and review of the literature. Pediatr Neurosurg 42:362–367
    • View reference on PubMed
    • View reference on publisher's website
  22. Hansen KN, Minousis M, Ebbesen F (2003) Weekly oral vitamin K prophylaxis in Denmark. Acta Paediatr 92:802–805
    • View reference on PubMed
    • View reference on publisher's website

Sign In

Connect with ICM

Top 5 Articles Editors Picks Supplement