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Sildenafil for pulmonary hypertension in ARDS: a new pleasant effect?

Lluis Blanch| Guillermo M. Albaiceta
Editorial
Volume 36, Issue 5 / May , 2010

Pages 729 - 731

No abstract available.

References

  1. Tomashefski JF Jr (2000) Pulmonary pathology of acute respiratory distress syndrome. Clin Chest Med 21:435–466
    • View reference on publisher's website
    • View reference on PubMed
  2. Squara P, Dhainaut JF, Artigas A, Carlet J (1998) Hemodynamic profile in severe ARDS: results of the European collaborative ARDS study. Intensive Care Med 24:1018–1028 Erratum in: Intensive Care Med 1999;25:247
  3. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA (2002) Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 346:1281–1286
    • View reference on publisher's website
    • View reference on PubMed
  4. Lucangelo U, Bernabè F, Vatua S, Degrassi G, Villagrà A, Fernandez R, Romero PV, Saura P, Borelli M, Blanch L (2008) Prognostic value of different dead space indices in mechanically ventilated patients with acute lung injury and ARDS. Chest 133:62–71
    • View reference on publisher's website
    • View reference on PubMed
  5. Moloney ED, Evans TW (2009) Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome. Eur Respir J 21:720–727
    • View reference on publisher's website
  6. Vieillard-Baron A, Schmitt JM, Augarde R, Fellahi JL, Prin S, Page B, Beauchet A, Jardin F (2001) Acute cor pulmonale in acute respiratory distress syndrome submitted to protective ventilation: incidence, clinical implications, and prognosis. Crit Care Med 29:1551–1555
    • View reference on publisher's website
    • View reference on PubMed
  7. Kaisers U, Busch T, Deja M, Donaubauer B, Falke KJ (2003) Selective pulmonary vasodilation in acute respiratory distress syndrome. Crit Care Med 31(Suppl):S337–S342
    • View reference on publisher's website
    • View reference on PubMed
  8. Blanch L, Joseph D, Fernández R, Mas A, Martinez M, Vallés J, Diaz E, Baigorri F, Artigas A (1997) Hemodynamic and gas exchange responses to inhalation of nitric oxide in patients with the acute respiratory distress syndrome and in hypoxemic patients with chronic obstructive pulmonary disease. Intensive Care Med 23:51–57
  9. Martinez M, Diaz E, Joseph D, Villagrá A, Mas A, Fernandez R, Blanch L (1999) Improvement in oxygenation by prone position and nitric oxide in patients with acute respiratory distress syndrome. Intensive Care Med 25:29–36
  10. Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO (2007) Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 334(7597):779
    • View reference on publisher's website
    • View reference on PubMed
  11. Cornet AD, Hofstra JJ, Swart EL, Girbes ARJ, Juffermans NP (2010) Sildenafil attenuates pulmonary arterial pressure, but does not improve oxygenation during ARDS. Intensive Care Med. doi:10.1007/s00134-010-1754-3
  12. Archer SL, Michelakis ED (2009) Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension. N Engl J Med 361:1864–1871
    • View reference on publisher's website
    • View reference on PubMed
  13. Mekontso Dessap A, Charron C, Devaquet J, Aboab J, Jardin F, Brochard L, Vieillard-Baron A (2009) Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med 35:1850–1858
  14. Rehberg S, Ertmer C, Westphal M (2009) Mechanical ventilation in patients with ARDS: is the lung’s fortune the right ventricle’s poison? Intensive Care Med 35:1825–1826
  15. Villagrá A, Ochagavía A, Vatua S, Murias G, Del Mar Fernández M, Lopez Aguilar J, Fernández R, Blanch L (2002) Recruitment maneuvers during lung protective ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 165:165–170
    • View reference on PubMed
  16. Albaiceta GM, Luyando LH, Parra D, Menendez R, Calvo J, Pedreira PR, Taboada (2005) Inspiratory vs. expiratory pressure-volume curves to set end-expiratory pressure in acute lung injury. Intensive Care Med 31:1370–1378
  17. Blanco I, Gimeno E, Munoz PA, Pizarro S, Rodriguez-Roisin R, Roca J, Barbera JA (2009) Hemodynamic and gas exchange effects of sildenafil in patients with COPD and pulmonary hypertension. Am J Respir Crit Care Med [Epub ahead of print]

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