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Outcome in bacteremia associated with nosocomial pneumonia and the impact of pathogen prediction by tracheal surveillance cultures

Pieter Depuydt| Dominique Benoit| Dirk Vogelaers| Geert Claeys| Gerda Verschraegen| Koenraad Vandewoude| Johan Decruyenaere| Stijn Blot
Original
Volume 32, Issue 11 / November , 2006

Pages 1773 - 1781

Abstract

Objective

To assess whether pathogen prediction in bacteremia associated with nosocomial pneumonia (NP) by tracheal surveillance cultures improves adequacy of early antibiotic therapy and impacts mortality.

Design and setting

A retrospective observational study of a prospectively gathered cohort. This cohort included all adult patients admitted to the ICU of a tertiary care hospital from 1992 through 2001 and who developed bacteremia associated with NP.

Measurements and main results

128 episodes of bacteremia associated with NP were identified. In 110 episodes a tracheal surveillance culture 48–96 h prior to bacteremia was available: this culture predicted the pathogen in 67 episodes (61%). Overall rates of appropriate empiric antibiotic therapy within 24 and 48 h were 62 and 87%, respectively. Pathogen prediction was associated with a significantly higher rate of appropriate antibiotic therapy within 24 h (71 vs 45%; p = 0.01), but not within 48 h (91 vs 82%; p = 0.15). Crude in-hospital mortality was 50%. Pathogen prediction was associated with increased survival in univariate (OR 0.43; CI 0.19–0.93; p = 0.04) and multivariate analysis (OR 0.32; CI 0.12–0.82; p = 0.02). Multivariate analysis further identified age (OR 1.04; CI 1.01–1.07; p = 0.02), increasing APACHE II score (OR 1.08; CI 1.02–1.15; p = 0.01), and methicillin-resistant Staphylococcus aureus (OR 5.90; CI 1.36–25.36; p = 0.01) and Pseudomonas aeruginosa (OR 3.30; CI 1.04–10.4; p = 0.04) as independent risk factors for mortality.

Conclusion

Pathogen prediction in bacteremia associated with NP by tracheal surveillance cultures is associated with a higher rate of adequate empiric antibiotic therapy within 24 h and with increased survival.

Keywords

References

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