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Cerebral perfusion pressure and cerebral tissue oxygen tension in a patient during cardiopulmonary resuscitation

Roberto Imberti| Guido Bellinzona| Francesca Riccardi| Michele Pagani| Martin Langer
Brief Report
Volume 29, Issue 6 / June , 2003

Pages 1016 - 1019

Abstract.

Objective: To report on the effects of cardiopulmonary resuscitation (CPR) instituted immediately after a cardiac arrest on cerebral perfusion pressure (CPP) and cerebral tissue oxygen tension (PbrO2).

Design: Case report.

Setting: ICU of a university hospital.

Patient: A head-injured 17-year-old man submitted to multimodal neurological monitoring underwent sudden cardiac arrest and successful CPR.

Interventions: External chest compression, 100% oxygen ventilation, volume expansion and standard ACLS protocols.

Measurements and results: Heart rate, ECG, mean arterial blood pressure (MABP), ETCO2,PaO2, intracranial pressure (ICP), CPP and PbrO2 were continuously monitored during CPR and data recorded at 15-s intervals by a dedicated personal computer. At the onset of the cardiac arrest, PbrO2 decreased to zero. The institution of CPR resulted in a progressive increase of MABP, CPP and PbrO2. Assuming, on the basis of previous experimental and clinical reports, 8 mmHg PbrO2 as a possible ischaemic/hypoxic threshold value, during the first 6.5 min of CPR, PbrO2 values were below this threshold (range 0–7 mmHg) and CPP values were <25 mmHg for 81.5% of the time. In the following 5.5 min, more efficient CPR generated CPP values >25 mmHg for 77.3% of the time. These values were associated with a PbrO2 >8 mmHg (range 8–28 mmHg) at all times.

Conclusions: In the clinical setting of a witnessed cardiac arrest, immediate institution of CPR can be effective in generating PbrO2 values above a supposed ischaemic/hypoxic threshold when CPP is >25 mmHg. PbrO2 monitoring by the Licox system is sensitive and reliable, even at low values, and can be suitable for evaluating cerebral oxygenation during experimental CPR.

Keywords

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